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1.
FIG. 6.

FIG. 6. From: Influence of Glycosylation on the Efficacy of an Env-Based Vaccine against Simian Immunodeficiency Virus SIVmac239 in a Macaque AIDS Model.

CD4+ T cells in PBMCs from rhesus macaques during immunization and after the challenge infection. A: Percentage of CD4+ T cells in PBMCs; B: percentage of CD4+ CD29high T cells in PBMCs.

Kazuyasu Mori, et al. J Virol. 2005 August;79(16):10386-10396.
2.
FIG. 4.

FIG. 4. From: Influence of Glycosylation on the Efficacy of an Env-Based Vaccine against Simian Immunodeficiency Virus SIVmac239 in a Macaque AIDS Model.

Humoral immune response during immunization and after challenge infection. The OD492 was used as a relative measurement of anti-SIV ELISA antibody titer.

Kazuyasu Mori, et al. J Virol. 2005 August;79(16):10386-10396.
3.
FIG. 2.

FIG. 2. From: Influence of Glycosylation on the Efficacy of an Env-Based Vaccine against Simian Immunodeficiency Virus SIVmac239 in a Macaque AIDS Model.

Expression of SU and Env by SU-expressing DNA vaccines and Env-expressing vaccinia viruses. A: SU secreted in supernatant from CV-1 cells transfected with SU-expressing plasmids. Lane 1, pJW4303 vector; lane 2, pJWSUmac239; lane 3, pJWSUmacΔ5G. B: Env in cell lysates of CV-1 cells infected with recombinant vaccinia viruses. Lane 1, WRvv; lane 2, WRvvmac239; lane 3, WRvvΔ5G.

Kazuyasu Mori, et al. J Virol. 2005 August;79(16):10386-10396.
4.
FIG. 5.

FIG. 5. From: Influence of Glycosylation on the Efficacy of an Env-Based Vaccine against Simian Immunodeficiency Virus SIVmac239 in a Macaque AIDS Model.

Plasma viral loads after SIVmac239 challenge infection. Plasma viral load was measured by real-time PCR with a detection limit of 1,000 copies/ml. A: wt-Env vaccine group; B: Δ5G Env vaccine group; C: vector controls; D: comparison of viral loads among three groups; E: comparison of viral loads during the primary infection (5 days to 6 weeks p.i.) and chronic infection (8 weeks to 45 weeks p.i.) among three groups. Viral load was determined by averaging over a period of time.

Kazuyasu Mori, et al. J Virol. 2005 August;79(16):10386-10396.
5.
FIG. 7.

FIG. 7. From: Influence of Glycosylation on the Efficacy of an Env-Based Vaccine against Simian Immunodeficiency Virus SIVmac239 in a Macaque AIDS Model.

SIV-specific CD8+ T-cell and CD4+ T-cell responses in 12 animals. A: SIV viral-protein-specific CD8+ T cells in PBMCs were measured by ELISPOT assay for IFN-γ in three groups: vector controls, wt-Env vaccine group, and Δ5G Env vaccines. B: SIV viral-protein-specific CD4+ T cells in PBMCs were measured by ELISPOT assay for IFN-γ in three groups. ELISPOT results of individual SIV proteins are colored as follows: Gag (red), Nef (green), Tat/Rev (blue), Vif/Vpr/Vpx (yellow), and Pol (pink). C: Comparison of cumulated CD8+ T cells or CD4+ T cells specific to the viral proteins Gag, Pol, Nef, Tat/Rev, and Vif/Vpr/VpX between SIV infection-controlled and uncontrolled animals. w, weeks; d, days.

Kazuyasu Mori, et al. J Virol. 2005 August;79(16):10386-10396.
6.
FIG. 1.

FIG. 1. From: Influence of Glycosylation on the Efficacy of an Env-Based Vaccine against Simian Immunodeficiency Virus SIVmac239 in a Macaque AIDS Model.

Outline of immunization, challenge infection, and blood sampling. Twelve juvenile rhesus macaques were divided into three immunization groups of four animals each: the wt-Env immunization group (Mm0005, Mm0007, Mm0010, and Mm0012), the Δ5G Env immunization group (Mm0001, Mm0002, Mm0003, and Mm0009), and the vector control immunization group (Mm0004, Mm0006, Mm0008, and Mm0011). Animals were inoculated with a DNA vaccine (pJWSUmac239 for the wt-Env vaccine group, pJWSUΔ5G for the Δ5G Env vaccine group, and pJW4303 for the vector control group) at 0, 4, and 8 weeks p.p. The boost vaccine consisted of vaccinia virus (WRvvENVmac239 for the wt-Env vaccine group, WRvvENVΔ5G for the Δ5G Env vaccine group, and the WR strain for the vector control group) administered at 21 weeks p.p. All animals were challenged with 10 TCID50 of SIVmac239 intravenously at 28 weeks p.p. w, weeks; d, day.

Kazuyasu Mori, et al. J Virol. 2005 August;79(16):10386-10396.
7.
FIG. 3.

FIG. 3. From: Influence of Glycosylation on the Efficacy of an Env-Based Vaccine against Simian Immunodeficiency Virus SIVmac239 in a Macaque AIDS Model.

Env-specific CD4+ T-cell and CD8+ T-cell responses in 12 macaques. A: Env-specific CD8+ T cells in PBMCs were measured by ELISPOT assay for IFN-γ in three groups. B: Env-specific CD4+ T cells in PBMCs were measured by ELISPOT assay for IFN-γ in three groups. ELISPOT results are colored as follows: Δ5G SU-specific T cells (red), wt-SU-specific T cells (green), and TM-specific T cells (yellow). Arrows with a dotted line, arrows with broken line, and arrows with a solid line indicate the time of the third DNA vaccination at 8 weeks p.p., the time of the vaccine boost at 21 weeks p.p., and the time of SIVmac239 challenge at 28 weeks p.p., respectively. C: Comparison of SU-specific CD8+ T cells and CD4+ T cells in PBMCs among the wt-Env vaccine group, the Δ5G Env vaccine group, and the vector control group at 26 weeks p.p. and 4, 7, and 12 days p.i. The numbers of SFC responding to SIVmac239 SU were used to compare the effects of the two vaccines. w, weeks; d, days.

Kazuyasu Mori, et al. J Virol. 2005 August;79(16):10386-10396.

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