Results: 4

1.
Fig. 2.

Fig. 2. From: Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene.

Behavioral development of mice with a disruption of the Foxp2 locus. (a) Weight of animals. (b) Righting. (c) Mid-air righting. (d) Negative geotaxis. (e) Opening of the eyes. (f) Extroversions of the ears. **, P < 0.005; ***, P < 0.0005.

Weiguo Shu, et al. Proc Natl Acad Sci U S A. 2005 July 5;102(27):9643-9648.
2.
Fig. 1.

Fig. 1. From: Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene.

Disruption of the murine Foxp2 locus. (a) Schematic for the construction of the Foxp2 targeting vector, showing restriction maps of the wild-type mouse Foxp2 gene (Top), targeting vector (Middle), and mutant allele (Bottom). The segment that includes exon 12 and exon 13 was replaced with a neomycin-resistance (neo-r) cassette; the thymidine kinase (TK) gene was used for negative selection. The external probe used for Southern blot analysis is shown (Bottom). (b) Southern blot analysis. The wild-type and the mutant allele generate a 14.0- and 4.0-kb band, respectively. (c) Immunoblotting of Foxp2. Actin was used as a loading control.

Weiguo Shu, et al. Proc Natl Acad Sci U S A. 2005 July 5;102(27):9643-9648.
3.
Fig. 3.

Fig. 3. From: Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene.

Histological analysis of brains from mice with a disruption of the Foxp2 locus. (af) Cerebellar sections from wild-type (a and d), heterozygous (b and e), and homozygous (c and f) knockout mice. (gi) Immunostaining for calbindin (green) in brains from wild-type (g), heterozygous (h), and knockout (i) animals. (jl) Immunostaining for GFAP (red) in brains from wild-type (j), heterozygous (k), and knockout (l) animals. The sections in gl are also stained with a DAPI nuclear stain (blue). gcl, granule cell layer; pcl, Purkinje cell layer; ml, molecular layer; egl, external granular layer. (Scale bar: 50 μm.)

Weiguo Shu, et al. Proc Natl Acad Sci U S A. 2005 July 5;102(27):9643-9648.
4.
Fig. 4.

Fig. 4. From: Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene.

Vocalization and behavior in mice with a disruption of the Foxp2 locus. (a) Number of ultrasonic vocalizations in 6 day old mice after separation from the dam. (b) Sample vocalization pattern showing both clicks (the two vertical traces covering both the sonic and ultrasonic region of the trace) and whistles (the four more vertical traces in the ultrasonic region of the trace). (c and d) Number of ultrasonic vocalizations (whistles) (c) and sonic/ultrasonic vocalizations (clicks) (d) in 10-day-old mice, after separation from the dam. (e) Shock sensitivity of adult mice. (f) Morris water maze performance of adult mice. *, P < 0.05; **, P < 0.005; ***, P < 0.0005.

Weiguo Shu, et al. Proc Natl Acad Sci U S A. 2005 July 5;102(27):9643-9648.

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