Results: 5

1.
Figure 5

Figure 5. From: Vascular endothelial growth factor acts as an osteolytic factor in breast cancer metastases to bone.

Graph showing the mean area of resorption after stimulating PBMCs for 3 weeks with the cytokines.

S E Aldridge, et al. Br J Cancer. 2005 April 25;92(8):1531-1537.
2.
Figure 4

Figure 4. From: Vascular endothelial growth factor acts as an osteolytic factor in breast cancer metastases to bone.

Scanning electron microscopy of ivory slice after culture with PBMCs stimulated by VEGF and RANKL. Example of resorption pit.

S E Aldridge, et al. Br J Cancer. 2005 April 25;92(8):1531-1537.
3.
Figure 2

Figure 2. From: Vascular endothelial growth factor acts as an osteolytic factor in breast cancer metastases to bone.

Tartrate-resistant acid phophatase staining of PBMCs after 2 weeks culture. (A) Negative control, (B) M-CSF and RANKL, (C) VEGF and RANKL.

S E Aldridge, et al. Br J Cancer. 2005 April 25;92(8):1531-1537.
4.
Figure 1

Figure 1. From: Vascular endothelial growth factor acts as an osteolytic factor in breast cancer metastases to bone.

(A) Specimen stained with antibodies against VEGF. The large pleomorphic tumour cells (arrows) express VEGF at relatively high levels. Serial sections stained with antibodies against (B) CD68 and (C) VEGFR2. There is obvious expression of VEGFR2 by the central tumour cells. The osteoclasts express CD68 (arrows) and can also be seen in (B) to express VEGFR2.

S E Aldridge, et al. Br J Cancer. 2005 April 25;92(8):1531-1537.
5.
Figure 3

Figure 3. From: Vascular endothelial growth factor acts as an osteolytic factor in breast cancer metastases to bone.

Graph showing mean numbers of multinucleated TRAP-positive cells after stimulation with cytokines (M=M-CSF, R=RANKL, V=VEGF). The experiments were carried out in both (A) PBMCs and (B) RAW 264.7 cells. The experiments were repeated in triplicate and typical graphs are shown here. Bars in stripes are significantly different on ANOVA at 95% CI from negative control. Grey bars are significantly different from positive control (M+R). White bars are different from both.

S E Aldridge, et al. Br J Cancer. 2005 April 25;92(8):1531-1537.

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