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F <span style="font-variant: small-caps" class="small-caps">igure</span>  2.—

F igure 2.—. From: Bacterial Persistence.

Ratio of growth rates of hipQ to wild type in the (tg, ts) plane. Time is given in hours. (A) bhip = 10−4; (B) bhip = 10−6. The black line in A and B is the curve of equal fitness, shown in Figure 1, along which the z-coordinate is identically zero.

Edo Kussell, et al. Genetics. 2005 April;169(4):1807-1814.
F <span style="font-variant: small-caps" class="small-caps">igure</span>  1.—

F igure 1.—. From: Bacterial Persistence.

Phase diagram for competition between wild type and hipQ in periodic environments. Growth and stress durations in hours are given by tg and ts, respectively. The strain with the higher fitness is indicated in each of the two regions. All parameter values used for this computation are given in Table 1. Extreme possible values of the switching parameter b of the hipQ mutant were considered: main figure uses bhip = 10−4; inset uses bhip = 10−6.

Edo Kussell, et al. Genetics. 2005 April;169(4):1807-1814.
F <span style="font-variant: small-caps" class="small-caps">igure</span>  4.—

F igure 4.—. From: Bacterial Persistence.

Stochastic competitions between wild type and hipQ at tg = 20 for various values of ts. For each data point, 100 simulations were run, starting from a 1:1 ratio of wild type to mutant. Ni was taken to be the given population size, while Nmax was set to 1.1 Ni. Due to long simulation times for N = 106, the points on this curve for ts < 3 are averages over 20 runs. The dotted line indicates the result in the large population (deterministic) limit.

Edo Kussell, et al. Genetics. 2005 April;169(4):1807-1814.
F <span style="font-variant: small-caps" class="small-caps">igure</span>  3.—

F igure 3.—. From: Bacterial Persistence.

Competition of wild type against hipQ at (tg, ts) = (20, 2.5), starting from 50,000 wild-type and 50,000 hipQ cells: (A) stochastic dynamics; (B) deterministic dynamics. Gray bars indicate periods of growth, while spaces between bars are periods of antibiotic stress. When the red and blue lines overlap completely, we use a dashed line to resolve them. Circled events are as follows: a is the formation of a single wild-type persister cell, which dies soon after; b is the complete extinction of normal cells of both wild type and hipQ; and c is the switch of a single hipQ persister cell to the normal type. In these simulations, Nmax = 110,000 and Ni = 100,000. Parameter values are given in Table 1, taking bhip = 10−4. Deterministic dynamics correspond to numerical solution of Equations 1, with population size rescaling, as in the stochastic simulation.

Edo Kussell, et al. Genetics. 2005 April;169(4):1807-1814.

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