Results: 4

1.
Fig. 2.

Fig. 2. From: Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease.

Motor activity in monkeys maintained on CR compared with controls (CON) before and after exposure to the neurotoxin MPTP. Mean distance moved within the cage (A) and mean speed of movement (B) did not differ significantly between diet groups before MPTP treatment but were significantly higher in CR monkeys compared with CON monkeys after MPTP treatment. Values are the means and SEM. *, P < 0.05 compared with CON after MPTP, two-tailed, unpaired t test with Welch's correction.

Navin Maswood, et al. Proc Natl Acad Sci U S A. 2004 December 28;101(52):18171-18176.
2.
Fig. 4.

Fig. 4. From: Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease.

Levels of BDNF and GDNF are increased in the striatum of MPTP-treated monkeys that had been maintained on a CR diet. Levels of BDNF (A) and GDNF (B) were measured by ELISA analysis in tissue samples from the CN (18). Values are the mean and SEM. (A) The BDNF level was greater in the right CN of the CR monkeys, but the difference did not reach statistical significance (ANOVA, F1,8 = 4.2, P = 0.74). (B) The GDNF concentration was significantly greater in the right CN of the CR compared with the control diet monkeys (ANOVA, F1,8 = 5.5; *, P = 0.045).

Navin Maswood, et al. Proc Natl Acad Sci U S A. 2004 December 28;101(52):18171-18176.
3.
Fig. 1.

Fig. 1. From: Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease.

Experimental design and body weights of monkeys in each diet group during the course of the study. All monkeys were injected with MPTP after being on their respective diet for 6 months. PET scans were conducted 1–3 weeks before MPTP-injections (after being on the diet for 5 months) and 12–16 weeks after MPTP injection while monkeys were being maintained on their respective diet. Movement assessment panel testing to measure manual dexterity was conducted 7 weeks after MPTP injections. All monkeys were euthanized 16–18 weeks after MPTP injection. There was a significant decline in body weights of the CR group compared with the control diet group (CON) throughout the study (P < 0.05, repeated-measures ANOVA).

Navin Maswood, et al. Proc Natl Acad Sci U S A. 2004 December 28;101(52):18171-18176.
4.
Fig. 3.

Fig. 3. From: Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease.

CR attenuates MPTP-induced depletion of DA and its metabolites in the striatum. (A) Concentrations of DA and its metabolites DOPAC and HVA were measured in tissue samples from three different regions of the striatum [lateral (Lat.), intermediate (Int.), and medial (Med.) regions] on both the left and right sides of the brain from MPTP-treated monkeys on the CR (n = 7) and control (n = 6) diets. Cd, caudate; Put, putamen; Acb, nucleus accumbens. (BD) Measurements of levels of DA (B), DOPAC (C), and HVA (D) reveal that the CR monkeys had significantly higher DA levels in the medial (t = 2.5, df = 10; *, P = 0.016) and intermediate (t = 1.95, df = 6; *, P = 0.049) regions of the striatum compared with the control diet monkeys in the right striatum. (B) In the left (the side not receiving MPTP) striatum the DA levels were not significantly different between the CR and control diet groups (*, P > 0.05). (C) The CR group had significantly elevated DOPAC content in the intermediate region of the left striatum (t = 1.90, df = 10; *, P = 0.043). The DOPAC content was also significantly higher in both the medial (t = 2.76, df = 8; *, P = 0.012) and intermediate (t = 2.42, df = 6; *, P = 0.026) regions of the right striatum. (D) In the left striatum there was no significant diet effect on the HVA content (P > 0.05). In the right striatum, the HVA content was elevated significantly in both the medial (t = 2.06, df = 10; *, P = 0.033) and lateral regions (t = 2.02, df = 7; *, P = 0.042).

Navin Maswood, et al. Proc Natl Acad Sci U S A. 2004 December 28;101(52):18171-18176.

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