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Results: 3

1.
FIG. 1.

FIG. 1. From: Specific T-Cell Epitopes for Immunoassay-Based Diagnosis of Mycobacterium tuberculosis Infection.

Amino acid sequences of the four diagnostic antigens. Synthetic 18- to 20-mer peptides spanning the proteins are indicated by horizontal double lines. Peptide numbers are used throughout the article.

Inger Brock, et al. J Clin Microbiol. 2004 June;42(6):2379-2387.
2.
FIG. 2.

FIG. 2. From: Specific T-Cell Epitopes for Immunoassay-Based Diagnosis of Mycobacterium tuberculosis Infection.

Recognition of the single peptides in M. bovis BCG-vaccinated individuals. (A) Level of recognition of single peptides spanning the four proteins in M. bovis BCG-vaccinated individuals. Synthetic peptides spanning the whole proteins were tested by measuring IFN-γ release after stimulation of PBMCs from healthy M. bovis BCG-vaccinated individuals (n = 28). Boxes represent the 25th to 75th percentiles, and bars show the maximum response. (B) Recognition frequencies of single peptides in M. bovis BCG-vaccinated individuals. Recognition frequencies (individuals with responses of >100 pg/ml to the individual peptides) of the single peptides in M. bovis BCG-vaccinated individuals are shown. Horizontal bars indicate the regions selected and pooled as diagnostic cocktails. Asterisks indicate the single peptides included in the Rv3873D cocktail.

Inger Brock, et al. J Clin Microbiol. 2004 June;42(6):2379-2387.
3.
FIG. 3.

FIG. 3. From: Specific T-Cell Epitopes for Immunoassay-Based Diagnosis of Mycobacterium tuberculosis Infection.

T-cell responses to ESAT-6, CFP-10, PPD, and the peptide cocktails. The proteins and peptide mixtures were tested in a panel of PBMCs from tuberculosis patients and M. bovis BCG-vaccinated healthy controls. Horizontal lines indicate the cutoff value of 100 pg/ml used for the initial selection of peptides. Solid squares represent patient responses to Rv2653A, Rv3873B, Rv3878A, and Rv3878B (n = 44) or ESAT-6, CFP-10, PPD, Rv3873A, Rv3873C, Rv3873D, and Rv2654 (n = 59), and open squares represent the 29 M. bovis BCG-vaccinated controls tested. For each antigen-peptide cocktail, recognition (>100 pg/ml) is given as the percentage of positive patients among M. bovis BCG-vaccinated controls and is indicated in the upper right-hand corner.

Inger Brock, et al. J Clin Microbiol. 2004 June;42(6):2379-2387.

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