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1.
Figure 5

Figure 5. From: Multiple Variable First Exons: A Mechanism for Cell- and Tissue-Specific Gene Regulation.

Genome-wide distribution of human and mouse genes that have more than one first exon. The numbers are shown above each histogram. The inset shows an enlargement of the distribution of genes with more than three first exons.

Theresa Zhang, et al. Genome Res. 2004 January;14(1):79-89.
2.
Figure 6

Figure 6. From: Multiple Variable First Exons: A Mechanism for Cell- and Tissue-Specific Gene Regulation.

Genomic organization of mouse plectin (A), human NOS1 (B), and rat GR (C) genes. Each gene contains a tandem array of multiple first exons in the variable region, each of which is separately spliced to a common set of downstream constant exons. The approximate length of each gene is shown below the corresponding panels.

Theresa Zhang, et al. Genome Res. 2004 January;14(1):79-89.
3.
Figure 3

Figure 3. From: Multiple Variable First Exons: A Mechanism for Cell- and Tissue-Specific Gene Regulation.

Phylogenetic tree of human, mouse, and rat UGT1 gene clusters. The tree was reconstructed based on variable region polypeptides by using the neighbor-joining method of the CLUSTAL W package. The tree branches are labeled with the percentage support for that partition based on 1000 bootstrap replicates. The scale bar equals a distance of 0.1.

Theresa Zhang, et al. Genome Res. 2004 January;14(1):79-89.
4.
Figure 2

Figure 2. From: Multiple Variable First Exons: A Mechanism for Cell- and Tissue-Specific Gene Regulation.

Tissue-specific expression profiles of mouse UGT1 gene cluster. The expression of UGT1 was assessed by DRT-PCR using primers specific for each isoform. We used an actin primer pair as an internal control. The tissue sources are shown on the left of each panel. The amplified cDNA products are indicated on the right of each panel. The band slightly above the actin cDNA is a nonspecific PCR product. The UGT1 isoforms are indicated above each lane. (M) Marker.

Theresa Zhang, et al. Genome Res. 2004 January;14(1):79-89.
5.
Figure 1

Figure 1. From: Multiple Variable First Exons: A Mechanism for Cell- and Tissue-Specific Gene Regulation.

Similar genomic organization of Pcdh and UGT1 gene clusters. Shown are comparisons of the genomic organization of mouse Pcdh (A), and mouse (B), rat (C), and human (D) UGT1 clusters. Each cluster has multiple, highly similar, tandem variable exons followed by one set of constant exons. They are indicated by vertical colored bars: (mauve) mouse Pcdhα variable exons; (yellow) C-type Pcdh variable exons; (green) phenol-type UGT1 variable exons; (orange) bilirubin-type UGT1 variable exons; (blue) pseudogenes or relics (present in both Pcdh and UGT1 clusters); (turquoise) non-UGT1 genes in the UGT1 cluster; (pink) constant exons (present in both Pcdh and UGT1 clusters). The approximate length of each cluster is shown below the corresponding panels. The pseudogenes are represented by a letter “p” following the gene symbol, whereas the relic sequences are represented by a letter “r.” (Pcdh) Protocadherin; (UGT) UDP glucuronosyltransferase; (Hsp40L) heat-shock protein 40kd like gene.

Theresa Zhang, et al. Genome Res. 2004 January;14(1):79-89.
6.
Figure 4

Figure 4. From: Multiple Variable First Exons: A Mechanism for Cell- and Tissue-Specific Gene Regulation.

Characteristics of the IGnT cluster. (A) Organization of the human, mouse, and rat IGnT clusters. Variable and constant exons are indicated. (B) Distribution of CpG islands in the genomic sequences of the human, mouse, and rat IGnT clusters. Shown are ratios of observed to expected CpG dinucleotide frequency of an 800-bp sliding window for the genomic sequences of the IGnT cluster in the three species. (C) A conserved motif and its relative position (negative numbers flanking the motif) to the translation start codon in the human, mouse, and rat IGnT clusters. The probability of finding the motif within 500 nt upstream of the translation start codon is shown within parentheses at the right. (D) Phylogenetic tree of the human, mouse, and rat IGnT variable protein sequences. (E) Percentage identities of a pairwise comparison between two human, mouse, or rat IGnT variable protein sequences.

Theresa Zhang, et al. Genome Res. 2004 January;14(1):79-89.

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