Results: 4

1.
Fig. 4.

Fig. 4. From: A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma.

Differences in survival between DLBCL subgroups. The Kaplan–Meier plots display the survival of patients in the GCB and ABC DLBCL subgroups defined by using gene expression data from Lymphochip (2) (Left) or Affymetrix (3) (Right) microarrays. A log-rank test was used to calculate the P values.

George Wright, et al. Proc Natl Acad Sci U S A. 2003 August 19;100(17):9991-9996.
2.
Fig. 3.

Fig. 3. From: A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma.

Prediction of DLBCL subgroups using gene expression measurements from oligonucleotide microarrays. The DLBCL subgroup predictor was used to discover ABC and GCB subgroups within 58 DLBCL biopsies that were profiled on Affymetrix microarrays (3). The probabilities that each sample belongs to the ABC or GCB subgroups are indicated. The differential expression of genes between the two subgroups is depicted according to the color scale in Fig. 1. Also shown for each gene are the P values derived from Wilcoxon rank-sum tests of the difference in expression between the two subgroups by using Affymetrix microarray data or Lymphochip microarray data, if available. N.S., P > 0.05. Asterisks indicate genes that were included in the DLBCL subgroup predictor.

George Wright, et al. Proc Natl Acad Sci U S A. 2003 August 19;100(17):9991-9996.
3.
Fig. 2.

Fig. 2. From: A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma.

Relationship of gene expression in normal B cell subpopulations to DLBCL subgroups. Relative gene expression in the indicated purified B cell subpopulations (see Methods) is depicted according to the color scale in Fig. 1. The P value of the difference in expression of these genes between the GCB and ABC DLBCL subgroups is shown, and the subgroup with the higher expression is indicated (blue, ABC DLBCL; orange, GCB DLBCL). (A) DLBCL subgroup distinction genes that are more highly expressed in germinal center B cells than at other B cell differentiation stages. (B) DLBCL subgroup distinction genes that are more highly expressed in plasma cells than at other B cell differentiation stages.

George Wright, et al. Proc Natl Acad Sci U S A. 2003 August 19;100(17):9991-9996.
4.
Fig. 1.

Fig. 1. From: A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma.

Performance of the DLBCL subgroup predictor using gene expression measurements from spotted cDNA microarrays. (A) The expression levels for the 27 genes in the subgroup predictor in 274 DLBCL samples (2) are depicted according to the color scale shown at the left. The 14 genes that were used to predict the DLBCL subgroups within the Affymetrix data set (Fig. 3) are indicated with asterisks. The probabilities that the DLBCL samples belong to the ABC or GCB subgroups are graphed at the top, and the DLBCL cases are arranged accordingly. The cases that belong to either the ABC or GCB DLBCL subgroups with ≥90% likelihood are indicated. (B) The assignments of the DLBCL cases to the ABC or GCB subgroups based on hierarchical clustering (2) vs. the subgroup predictor are compared within the training, validation, and total set of samples.

George Wright, et al. Proc Natl Acad Sci U S A. 2003 August 19;100(17):9991-9996.

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