Results: 4

1.
Figure 3

Figure 3. From: TOX defines a conserved subfamily of HMG-box proteins.

Comparison of TOX and LCP1. (A) Graphical representation of an unfiltered BLAST alignment comparing TOX and LCP1 proteins. Breaks in the proteins to allow maximum alignment are represented by a line. Residues in TOX that are identical to the aligned LCP1 protein are shown in black, while differences are shown in red. The NLS and HMG-box regions are indicated by green and blue bars, respectively. (B) Northern analysis of LCP1 gene expression in normalized poly-A+ RNA isolated from various tissues. The signal obtained from a probe to the housekeeping GAPDH gene is also shown as a loading control.

Emmett O'Flaherty, et al. BMC Genomics. 2003;4:13-13.
2.
Figure 1

Figure 1. From: TOX defines a conserved subfamily of HMG-box proteins.

Comparison of HMG-box sequences. The HMG-box region of TOX is aligned with the HMG-box motifs found in seven other proteins representing the two major subfamilies of HMG-box proteins. Similarities between the HMG-boxes of both groups of proteins are highlighted in gray and include matches to the consensus HMG-box domain (accession number pf00505) defined in the Pfam protein families' database. Residues in red and purple distinguish these two subgroups of HMG-box proteins and are discussed in the text. In addition, the consensus sequence GXXW (or more rarely AXXW, as also found in TOX) found commonly in HMG-boxes is shown in blue.

Emmett O'Flaherty, et al. BMC Genomics. 2003;4:13-13.
3.
Figure 4

Figure 4. From: TOX defines a conserved subfamily of HMG-box proteins.

Identification of TOX subfamily predicted proteins in pufferfish and mosquito. Shown is an amino acid comparison of the TOX NLS and HMG-box regions with predicted proteins encoded in the Fugu rubripes or Anopheles gambiae genomes. Fugu rubripes predicted proteins are designated here simply by the scaffold (Scaf) location of the corresponding gene (see Methods). Amino acids that differ from the TOX HMG-box are highlighted in red, the putative NLS regions are highlighted in green, and the AXXW motif is highlighted in blue. The vertical line represents the position of the conserved exon boundary of the respective genes. Alternative amino acids found in other mammalian family members are also shown (family).

Emmett O'Flaherty, et al. BMC Genomics. 2003;4:13-13.
4.
Figure 2

Figure 2. From: TOX defines a conserved subfamily of HMG-box proteins.

Murine TOX subfamily members and their human homologues. (A) The HMG-box and putative NLS regions within each predicted protein are shown in blue and green, respectively. The predicted size and molecular weight of each protein and the chromosomal location of the gene that encodes the protein are also indicated. *Note that the predicted protein LOC241768 as it currently exists in the NCBI database has been modified, and there is some question as to chromosomal location (see Methods). (B) Pair-wise comparison of HMG-box domains of murine and human TOX subfamily members. The upper predicted protein of each pair is mouse derived. Residues that differ from TOX are highlighted in red and the AXXW motif is highlighted in blue. The vertical line represents the position of the conserved exon boundary of the respective genes. (C) Comparison of predicted NLS of murine and human TOX subfamily members. The consensus motif is highlighted in green.

Emmett O'Flaherty, et al. BMC Genomics. 2003;4:13-13.

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