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1.
Figure 1

Figure 1. From: The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone.

Gross appearance of (a) 23-day-old CaR–/–, CaR+/– and CaR+/+ mice and (b) 10-week-old Pth–/–CaR–/–, Pth–/–CaR+/–, and Pth–/–CaR+/+ mice.

Claudine H. Kos, et al. J Clin Invest. 2003 April 1;111(7):1021-1028.
2.
Figure 4

Figure 4. From: The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone.

Histologic appearance of parathyroid gland from control mice (a) and Pth–/–CaR–/– sex-matched littermates (b). Sections were prepared from adult mice for light microscopy and stained with H&E.

Claudine H. Kos, et al. J Clin Invest. 2003 April 1;111(7):1021-1028.
3.
Figure 6

Figure 6. From: The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone.

Morphological findings in vertebral bone of control (a and c) and Pth–/–CaR–/– (b and d) sex-matched littermates. Saggital (a and b) and coronal (c and d) sections of spines from adult mice prepared for light microscopy and stained with H&E.

Claudine H. Kos, et al. J Clin Invest. 2003 April 1;111(7):1021-1028.
4.
Figure 3

Figure 3. From: The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone.

Graph showing the range of values for (a) serum calcium levels, (b) urine calcium to urine creatinine ratio, and (c) fractional excretion of calcium for control mice (filled squares) and Pth–/–CaR–/– sex-matched littermates (filled triangles).

Claudine H. Kos, et al. J Clin Invest. 2003 April 1;111(7):1021-1028.
5.
Figure 2

Figure 2. From: The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone.

Body weight of Pth–/–CaR–/– and control mice as a function of age. Pth–/–CaR–/– mice (gray bars) and control sex-matched littermates (black bars) were weighed between 3.5 and 12 weeks of age. Each column represents the mean ± SD derived from 8–15 measurements.

Claudine H. Kos, et al. J Clin Invest. 2003 April 1;111(7):1021-1028.
6.
Figure 5

Figure 5. From: The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone.

Expression levels of CaT1 and CaT2/ECaC are altered in Pth–/–CaR–/– mice relative to control littermates. The mRNA expression levels of CaT1 (black bars) and CaT2/ECaC (white bars) in the duodenum and kidney were assessed by real-time quantitative PCR and normalized against GAPDH mRNA levels. We compared expression in RNA samples from three pairs of sex-matched littermates maintained on high-calcium diets (2% calcium, top) and three pairs of sex-matched littermates on regular diets (0.81% calcium, bottom). We performed assays in duplicate for each RNA sample. Renal CaT1 and CaT2/ECaC expression were consistently higher in CaR-deficient mice, regardless of diet (mean increased expression of 65% and 60%, respectively). These differences reached statistical significance with P = 0.015 and P = 0.0025, respectively, in paired t tests. Intestinal CaT1 expression was highly variable. In animals fed high-calcium diets as well as those fed regular diets, the overall trend was toward increased CaT1 expression in the CaR-deficient animals, but this trend did not reach statistical significance either when the groups were analyzed separately according to diet or when all six pairs were analyzed together.

Claudine H. Kos, et al. J Clin Invest. 2003 April 1;111(7):1021-1028.

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