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Results: 5

1.
Figure 2.

Figure 2. From: Distinct Transcriptional Profiles of Adrenocortical Tumors Uncovered by DNA Microarray Analysis.

Histology of typical ACC and the three outlying tumors identified by PCA. ACC13 is a well-differentiated or low-grade ACC. ACC14 is a myxoid variant of ACC. ACC19 is a poorly differentiated ACC. ACC17 is a typical high-grade ACC. H&E; original magnification, ×200.

Thomas J. Giordano, et al. Am J Pathol. 2003 February;162(2):521-531.
2.
Figure 4.

Figure 4. From: Distinct Transcriptional Profiles of Adrenocortical Tumors Uncovered by DNA Microarray Analysis.

Up-regulation of IGF2 in ACC. A: Expression of IGF2, represented by three probe sets (light gray = 36782_s_at, medium gray = 1591_s_at, and dark gray = 2079_s_at), in the adrenocortical samples. B: Q-RT-PCR for IGF2 and GAPDH in the adrenocortical samples. Samples are labeled as follows: N = NC, A = ACA, H = MNH, and C = ACC.

Thomas J. Giordano, et al. Am J Pathol. 2003 February;162(2):521-531.
3.
Figure 5.

Figure 5. From: Distinct Transcriptional Profiles of Adrenocortical Tumors Uncovered by DNA Microarray Analysis.

Array transcript data and protein validation studies of select proliferation markers. A: Up-regulation of TOP2A in ACC. Transcript data for three probe sets (light gray = 40145_at, medium gray = 904_s_at, and dark gray = 1592_at) the adrenocortical cohort and two representative tissue cores that show high- and low-level immunoreactivity for TOP2A. B: Up-regulation of Ki-67 in ACC. Transcript data (419_at) for the adrenocortical cohort and two representative tissue cores that show high and moderate levels of mib-1 immunoreactivity.

Thomas J. Giordano, et al. Am J Pathol. 2003 February;162(2):521-531.
4.
Figure 1.

Figure 1. From: Distinct Transcriptional Profiles of Adrenocortical Tumors Uncovered by DNA Microarray Analysis.

Probe sets (n = 2913) with mean expression greater than 200 and SD divided by the mean >0.5 for the entire data set were selected. A: First two principal components for these probe sets. Probe sets were standardized by subtracting the mean and dividing by the SD. B: Dendrogram from average clustering 62 using these probe sets. C and D: Similar principal components and dendrograms using only 91 probe sets with a fold change greater than three between the carcinoma and normal/adenoma cohorts with a P < 0.01 in both cases.

Thomas J. Giordano, et al. Am J Pathol. 2003 February;162(2):521-531.
5.
Figure 3.

Figure 3. From: Distinct Transcriptional Profiles of Adrenocortical Tumors Uncovered by DNA Microarray Analysis.

Ninety-one probe sets that gave P < 0.01 for F-tests of both carcinoma versus normal and carcinoma versus adenoma that also had both fold changes larger than three, or smaller than 0.333 (see text). A central value for each probe set was determined by averaging log-transformed data, and taking the anti-logarithm. Colors represent the fold change for each sample from this value. The heat map was made using Treeview. 65 The probe set designation, the gene symbol, and the unigene title, as well as the fold change in transcript level, are shown. Samples are labeled as follows: N = NC, A = ACA, H = MNH, and C = ACC.

Thomas J. Giordano, et al. Am J Pathol. 2003 February;162(2):521-531.

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