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Results: 3

1.
Figure  3

Figure 3. From: Powerful Regression-Based Quantitative-Trait Linkage Analysis of General Pedigrees.

Structure for simulated cousin pedigree

Pak C. Sham, et al. Am J Hum Genet. 2002 August;71(2):238-253.
2.
Figure  1

Figure 1. From: Powerful Regression-Based Quantitative-Trait Linkage Analysis of General Pedigrees.

Theoretical sibship NCP over squared QTL variance Q2, obtained from equation (2) for the regression method and from appendix D for the VC method, under the assumption of a sibling correlation of 0.25.

Pak C. Sham, et al. Am J Hum Genet. 2002 August;71(2):238-253.
3.
Figure  2

Figure 2. From: Powerful Regression-Based Quantitative-Trait Linkage Analysis of General Pedigrees.

Effect of model misspecification. Each point represents the average χ2 statistic obtained from 2,000 simulated replicates, containing 250 sib quads. The QTL and residual polygenic variances are 0.2 and 0.3, respectively. In each case, the true trait model has mean 0, variance 1, and heritability 0.5. The misspecified mean, variance, and covariance are shown on the X-axes of panels a, b, and c, respectively. “Perfect marker” represents complete IBD information; “imperfect marker” represents a diallelic marker with equally frequent alleles.

Pak C. Sham, et al. Am J Hum Genet. 2002 August;71(2):238-253.

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