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Results: 7

1.
Figure 5

Figure 5. From: Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.

PCR amplification of TIP39 cDNA from rat neuronal and peripheral tissues. The predicted size of the product amplified from cDNA is 297 bp; from genomic DNA it is 594 bp.

Arpad Dobolyi, et al. Proc Natl Acad Sci U S A. 2002 February 5;99(3):1651-1656.
2.
Figure 3

Figure 3. From: Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.

Responses to TIP39 administration. (a) Force of the paw-withdrawal response immediately after intraplantar administration of various doses of TIP39. (b) Time spent performing scratching, biting, and licking (SBL) behaviors during the 20 min after intrathecal administration of TIP39.

Arpad Dobolyi, et al. Proc Natl Acad Sci U S A. 2002 February 5;99(3):1651-1656.
3.
Figure 7

Figure 7. From: Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.

TIP39-immunoreactive fibers in the spinal cord. (a) Horizontal section showing TIP39-immunoreactive fibers in craniocaudal orientation in the lateral funiculus. (b) Coronal section showing TIP39-immunoreactive fibers in lamina X and at the dorsal column-gray matter border. DH, dorsal horn; CC, central canal. [Bars = 200 μm (a), 50 μm (b).]

Arpad Dobolyi, et al. Proc Natl Acad Sci U S A. 2002 February 5;99(3):1651-1656.
4.
Figure 4

Figure 4. From: Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.

Modulation of nociceptive responses by intrathecal administration of an antibody to TIP39 or TIP39 itself. Tail-flick (a, d), paw pressure (b, e), and Hargreaves' (radiant heat directed to a paw; c, f) assays were performed as described in Materials and Methods. Responses after intrathecal delivery of vehicle (Veh), antibody to TIP39 (α-TIP), or preimmune serum (Pre Imm) are shown at 30 min after injection, the time at which the largest effect of the antibody was observed (ac). Responses at various times after injection of vehicle or 100 fmol of TIP39 (TIP39) are shown (df).

Arpad Dobolyi, et al. Proc Natl Acad Sci U S A. 2002 February 5;99(3):1651-1656.
5.
Figure 2

Figure 2. From: Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.

Laminar localization of the PTH2 receptor in the dorsal horn of mouse spinal cord. PTH2 receptor immunoreactivity was detected with a green labeled secondary antibody and CGRP (a, b), isolectin B4 (c, d), protein kinase C gamma (e), and substance P (f), with red labeled secondary antibodies. High-power confocal microscopy indicates that there is virtually no colocalization between PTH2 receptor and CGRP (b) immunoreactivity or isolectin B4 labeling (d). [Bars = 100 μm (a, c, e, f), 20 μm (b, d).]

Arpad Dobolyi, et al. Proc Natl Acad Sci U S A. 2002 February 5;99(3):1651-1656.
6.
Figure 1

Figure 1. From: Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.

In situ hybridization detection of PTH2 receptor mRNA in rat spinal cord and DRG. (a) Low-magnification dark-field micrograph. Part of the spinal cord gray matter at the thoracic level, and an attached DRG are outlined. Note hybridization in outer layers of the spinal cord dorsal horn, in scattered cells in deeper spinal cord layers, and in the DRG. (b) Higher-magnification bright-field image of a DRG. Note accumulation of silver grains (black) over some smaller neurons. Blue shows cellular counterstaining. * indicates central canal. [Bars = 1 mm (a), 100 μm (b).] Approximately 10–15% of DRG neurons are distinctly labeled by in situ hybridization. Antibody labeling (not shown) shows a continuum of intensity and numerical estimates are difficult to make.

Arpad Dobolyi, et al. Proc Natl Acad Sci U S A. 2002 February 5;99(3):1651-1656.
7.
Figure 6

Figure 6. From: Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.

Brain localization of TIP39-containing cells. (ae) caudal paralemniscal nucleus at −8.7 mm from the bregma level. (fj) subparafascicular area at −4.4 mm from the bregma. Drawings from the atlas of Paxinos and Watson (39) indicate the location of the micrographs (a, f). The localization of TIP39 mRNA detected by in situ hybridization histochemistry is shown at low magnification in dark-field micrographs (b, g) and at greater magnification of the framed areas in bright field (c, h). The localization of TIP39 protein is demonstrated by peroxidase immunocytochemistry in colchicine-treated animals, shown at low magnification (d, i) and at greater magnification of the framed areas (e, j). DR, dorsal raphe nucleus; fr, fasciculus retroflexus; ll, lateral lemniscus; PH, posterior hypothalamic area; PnO, pontine reticular nucleus, oral part; PrC, precomissural nucleus, posterior; pv, periventricular fiber system; PVP, paraventricular thalamic nucleus, posterior part; py, pyramidal tract; rs, rubrospinal tract; scp, superior cerebellar peduncle; VLL, ventral nucleus of lateral lemniscus; 3V, third ventricle. [Bars = 1 mm (a, b, d), 100 μm (c, e, h, j), 500 μm (g, h, i).]

Arpad Dobolyi, et al. Proc Natl Acad Sci U S A. 2002 February 5;99(3):1651-1656.

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