Results: 3

1.
Figure 1

Figure 1. From: Copper-64-diacetyl-bis(N4-methylthiosemicarbazone): An agent for radiotherapy.

Structure of Cu-ATSM.

Jason S. Lewis, et al. Proc Natl Acad Sci U S A. 2001 January 30;98(3):1206-1211.
2.
Figure 3

Figure 3. From: Copper-64-diacetyl-bis(N4-methylthiosemicarbazone): An agent for radiotherapy.

(A) Transaxial PET images of 64Cu-ATSM localized in the GW39 tumor 24-h after administration. Position of the tumor mass is confirmed by T2-weighted MRIs of the same hamster in the same plane. (B) T2-weighted transaxial MRI of two age-matched hamsters with the GW39 tumor in the thigh. The abnormal mass was still present 4 weeks after 64Cu-ATSM treatment (Left). However, the age-matched tumor growth without the treatment (Right) resulted in a tumor nodule that occupied the entire thigh. (C) T2-weighted MRI of a hamster with the GW39 tumor in the thigh. The abnormal mass was still present 5 weeks after 64Cu-ATSM treatment but with little change in overall volume. The pitted appearance is noted in the tumor mass at 36 days, suggestive of a fibrotic response.

Jason S. Lewis, et al. Proc Natl Acad Sci U S A. 2001 January 30;98(3):1206-1211.
3.
Figure 2

Figure 2. From: Copper-64-diacetyl-bis(N4-methylthiosemicarbazone): An agent for radiotherapy.

Summary of therapy results obtained with the cardiac-puncture administration of 64Cu-ATSM in hamsters bearing the GW39 carcinoma. Endpoint was 135 days or a tumor burden of 10 g, whichever came first. (A) Therapy of 7-day-old GW39 tumors in hamsters. Single administration of saline and hydralazine (♦, n = 10), 10 mCi of 64Cu-ATSM without hydralazine (■, n = 10), or 10 mCi of 64Cu-ATSM with hydralazine pretreatment (▴, n = 9). (B) Therapy of 7-day-old GW39 tumors in hamsters by using dose fractionation. Administration of saline, (♦, n = 10), 3 × 4 mCi of 64Cu-ATSM at 72-h intervals without hydralazine (■, n = 13), or 3 × 4 mCi of 64Cu-ATSM at 72-h intervals with hydralazine pretreatment (▴, n = 13). (C) Therapy of 7-day-old GW39 tumors in hamsters. Comparison of 10 (▴, n = 10), 8 (■, n = 11), and 6 (♦, n = 12) mCi. (D) Therapy of 15-day-old GW39 tumors in hamsters. Comparison of 4 (♦, n = 7), 6 (●, n = 9), 7 (⋄, n = 9), 8 (▵, n = 9), and 10 (▴, n = 10) mCi.

Jason S. Lewis, et al. Proc Natl Acad Sci U S A. 2001 January 30;98(3):1206-1211.

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