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Results: 2

1.
Figure  1

Figure 1. From: Familial Primary Pulmonary Hypertension (Gene PPH1) Is Caused by Mutations in the Bone Morphogenetic Protein Receptor-II Gene.

Intron/exon structure of the human BMPR2 gene. Intron and exon sizes are as indicated. Protein start and stop codons are indicated by the horizontal arrow and “TGA,” respectively. Mutations that cause premature termination of BMPR2 are shown as blackened arrows; unblackened arrows denote mutations in Arg491. The transmembrane and kinase domains are encoded by the indicated exons.

Zemin Deng, et al. Am J Hum Genet. 2000 September;67(3):737-744.
2.
Figure  2

Figure 2. From: Familial Primary Pulmonary Hypertension (Gene PPH1) Is Caused by Mutations in the Bone Morphogenetic Protein Receptor-II Gene.

Sequence alignment of the type II TGF-β–superfamily receptors surrounding R491 in BMPR-II. The mutation in families PPH001, PPH008, and PPH021 was aligned with all known type II receptors (>50), and 14 of these are displayed. TGFR-II = TGF-β–receptor type II; ActR-II = activin receptor type II; AMHR-II = anti–mullerian hormone type II receptor; DAF-4 = development-regulatory growth factor type IV; XSTK3 = Xenopus activin receptor.

Zemin Deng, et al. Am J Hum Genet. 2000 September;67(3):737-744.

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