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1.
Figure 4.

Figure 4. From: The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats.

Genetic distribution of SIA-induced F2(DA×LEW.1AV1) intercrosses with regards to the arthritis susceptibility-linked regions: A, OiaW; B, Oia2; and C, Oia3. Dots represent the specific genotype of each individual. The y axis represents the maximum arthritis score for each individual. The Kruskall-Wallis test was used in the statistical analyses.

Barbro C. Carlson, et al. Am J Pathol. 2000 June;156(6):2057-2065.
2.
Figure 1.

Figure 1. From: The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats.

Macroscopic appearance of squalene-induced arthritis (SIA) depicted as mean score in female (filled squares, n = 8) and male (empty squares, n = 9) DA rats. The arthritis is typically monophasic, leaving no permanent deformation of the joints.

Barbro C. Carlson, et al. Am J Pathol. 2000 June;156(6):2057-2065.
3.
Figure 5.

Figure 5. From: The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats.

Plasma fibrinogen levels of normal, pre-arthritic, and arthritic DA rats, respectively. Levels are presented as percentage of normal control plasma. The Kruskall-Wallis test was used in the statistical analyses, giving a P value of 0.0013.

Barbro C. Carlson, et al. Am J Pathol. 2000 June;156(6):2057-2065.
4.
Figure 2.

Figure 2. From: The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats.

Microscopic appearances of arthritic joints in DA rats, day 20 after squalene induction. A: Pannus infiltrating the joint (HTX/Eosin, 210 × magnification) with (B) infiltrating αβ+ T cells (IHC staining, detected using the avidin-biotin complex with diaminobenzene as substrate; original magnification, ×210). C: Overview of the joint. Arrow denotes typical fibrin deposition in the joint space (HTX/eosin; original magnification, ×55). D: The same section; original magnification, ×210. Arrow indicates chondrolysis.

Barbro C. Carlson, et al. Am J Pathol. 2000 June;156(6):2057-2065.
5.
Figure 3.

Figure 3. From: The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats.

Effect of therapeutic αβ+ T cell depletion in DA rats with squalene-induced arthritis. Rats injected i.p. with depleting mAbs against αβ TcR (R73, filled circles; n = 4) recovers from SIA within 1 day, whereas DA rats given an i.p. injection with nondepleting control mAbs (D10, open circles; n = 5) still have a severe arthritis. The arrow indicates the time of administration of mAbs (day 14 p.i.). *P < 0.05, **P < 0.01.

Barbro C. Carlson, et al. Am J Pathol. 2000 June;156(6):2057-2065.

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