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Results: 5

1.
Figure 4

Figure 4. From: Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex.

Electron micrographs of ultrathin sections taken through the superficial layers of patas (A) and rat (B) PFC, immunostained for Reln. In both patas and rat, the immunoperoxidase reaction product in dendritic spines is concentrated in the area of the postsynaptic densities. (Magnification, ×50,000.)

Miguel A. Rodriguez, et al. Proc Natl Acad Sci U S A. 2000 March 28;97(7):3550-3555.
2.
Figure 1

Figure 1. From: Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex.

Photomicrographs of 20-μm sections showing the distribution of NeuN- and Reln-expressing cells in the PFC, CingC, and VC of the baboon. Note that immunostaining for Reln strongly labels a small population of cells predominantly located in layer I. In addition to these Reln-expressing cells, there appears to be a faint immunolabeling of Reln on many pyramidal cells in deeper cortical layers. (Calibration bar = 200 μm.)

Miguel A. Rodriguez, et al. Proc Natl Acad Sci U S A. 2000 March 28;97(7):3550-3555.
3.
Figure 2

Figure 2. From: Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex.

Confocal microscope images showing the double labeling for Reln and GAD67 in layers I and II in 20-μm sections from the PFC of baboon brain. (Left) The expression of Reln (fluorescein; green) in the somata and proximal dendrite of three cells. (Middle) The expression of GAD67 (Texas Red; red) in the same section. The colocalization frequency between Reln and GAD67 (Right, Overlay) illustrates that Reln appears to be expressed in GABAergic cells in the baboon PFC. (Calibration bar = 20 μm.)

Miguel A. Rodriguez, et al. Proc Natl Acad Sci U S A. 2000 March 28;97(7):3550-3555.
4.
Figure 3

Figure 3. From: Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex.

Photomicrographs showing immunolabeling for GAD67 (A), Dab1 (B), Reln (C), and integrin α3 subunit in the patas PFC. (A) Immunostaining for GAD67 reveals a GAD67-positive GABAergic cell (solid arrow) as well as numerous punctate GAD67-positive terminal endings in the neuropil and surrounding excitatory pyramidal cells (open arrows) of layer V. (B) Immunostaining for Dab1 in layer V shows that it is expressed in excitatory pyramidal cells. (C) Immunostaining for Reln reveals cells that appear to contain Reln, such as the GABAergic bitufted cell indicated with a solid arrow in layer III, as well as many pyramidal cells that appear to have a light dusting of Reln (open arrows). (D) Photomicrograph of layer V showing that the integrin α3 subunit appears to be well expressed on pyramidal cells and their apical dendrites. (Calibration bar = 20 μm.)

Miguel A. Rodriguez, et al. Proc Natl Acad Sci U S A. 2000 March 28;97(7):3550-3555.
5.
Figure 5

Figure 5. From: Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex.

Electron micrographs of ultrathin sections of Reln immunolabeling in the patas PFC layers I and II. (A) Immunoperoxidase reaction product in a dendritic spine is concentrated in the area of the postsynaptic density as well as the surrounding dendritic plasma membrane. (B) Double-immunolabeling showing the colocalization of Reln (immunoperoxidase-diaminobenzidine) and integrin α3-subunit (silver-enhanced 1-nm ImmunoGold) in ultrathin sections from patas PFC layers I and II. Both dendritic processes present in this electron micrograph are immunopositive for Reln and integrin α3-subunit. (C) Higher magnification of the area outlined in B. Pre, presynaptic bouton with synaptic vesicles; Post, postsynaptic spine; Den, dendritic process. (Magnification: A = ×75,000; B = ×125,000; C = ×212,500.)

Miguel A. Rodriguez, et al. Proc Natl Acad Sci U S A. 2000 March 28;97(7):3550-3555.

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