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Results: 3

1.
Figure  1

Figure 1. From: Melanocortin-1 Receptor Polymorphisms and Risk of Melanoma: Is the Association Explained Solely by Pigmentation Phenotype?.

Use of allele-specific oligonucleotides for MC1R genotyping. A total of 100 ng each of PCR-amplified MC1R consensus and variant product were bound both independently (homozygote) and as an equimolar mixture (heterozygote) to nylon membranes and were hybridized with consensus or variant 15-base oligonucleotides, as indicated. Hybridization and washing of the [32P]-labeled oligonucleotides, in the presence of TMAC, differentiates each of the six MC1R variants examined in this study.

James S. Palmer, et al. Am J Hum Genet. 2000 January;66(1):176-186.
2.
Figure  2

Figure 2. From: Melanocortin-1 Receptor Polymorphisms and Risk of Melanoma: Is the Association Explained Solely by Pigmentation Phenotype?.

Association of MC1R variants with hair color. The percentage of individuals carrying a variant MC1R genotype at the five positions tested is shown, plotted against hair color. At the left-hand side of the graph are the frequencies of the MC1R consensus genotype, represented by “0,” and the total for any variant genotype, represented as “1,” “2,” or “3” variants, in the 818 samples genotyped, for which hair-color data, which sums to 100% for each hair color, are available (table 2). The absolute percentage of each variant position considered to be independently carried on one or both alleles, represented as “1” or “2,” is also plotted against hair color, which is on the right-hand side of the graph.

James S. Palmer, et al. Am J Hum Genet. 2000 January;66(1):176-186.
3.
Figure  3

Figure 3. From: Melanocortin-1 Receptor Polymorphisms and Risk of Melanoma: Is the Association Explained Solely by Pigmentation Phenotype?.

Association of MC1R variants with skin color. The percentage of individuals carrying a variant MC1R genotype at the five positions tested is shown, plotted against skin color. At the left-hand side of the graph are the frequencies of the MC1R consensus genotype, represented by “0,” and the total for any variant genotype, represented as “1,” “2,” or “3” variants, in the 637 samples genotyped, for which skin-color data, which sums to 100% for each skin color, are available (table 2). The absolute percentage of each variant position considered to be independently carried on one or both alleles, represented as “1” or “2,” is also plotted against skin color, which is on the right-hand side of the graph.

James S. Palmer, et al. Am J Hum Genet. 2000 January;66(1):176-186.

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