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Results: 3

1.
Figure 3

Figure 3. From: The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin.

(a) Duodenal biopsy (villus tip, ×40) immunostained for P-gp before administration of rifampin. (b) Duodenal biopsy (villus tip, ×40) immunostained for P-gp after 9 days administration of rifampin (600 mg), obtained from the same volunteer as in a.

Bernd Greiner, et al. J Clin Invest. 1999 July 15;104(2):147-153.
2.
Figure 1

Figure 1. From: The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin.

(a) Mean (n = 8) plasma concentration (mean ± SD) time curves of orally administered digoxin (1 mg) before (open circles) and during (filled circles) coadministration of rifampin (600 mg). (b) Mean (n = 8) plasma concentration (mean ± SD) time curves of intravenously administered digoxin (1 mg) before (open circles) and during (filled circles) coadministration of rifampin (600 mg).

Bernd Greiner, et al. J Clin Invest. 1999 July 15;104(2):147-153.
3.
Figure 2

Figure 2. From: The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin.

(a) Correlation between AUC of orally administered digoxin (1 mg) and expression of P-gp (n = 16), measured by immunohistochemistry using TV-densitometry before and after coadministration of rifampin. Open squares = without rifampin; closed squares = with rifampin (600 mg). (b) Western blot of biopsy biopsy homogenates showing the induction of P-gp expression. Lanes 1–8, 50 μg biopsy homogenate of volunteers 1–8 taken before rifampin treatment; lanes 1r–8r, 50 μg biopsy homogenate of volunteers 1–8 taken after rifampin treatment; lanes pc1 and pc2, L-MDR1 cell homogenates (positive control, 2/10 μg); nc, LLC-PK1 cell homogenate (negative control, 25 mg). (c) Correlation between AUC of orally administered digoxin (1 mg) and expression of P-gp (n = 16) measured by Western blot. Open squares = without rifampin; filled squares = with rifampin (600 mg).

Bernd Greiner, et al. J Clin Invest. 1999 July 15;104(2):147-153.

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