Results: 4

1.
Figure 4

Figure 4. From: Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis.

Analysis of the percent inhibition of COX-1 seen when COX-2 (WHMA) is inhibited by 80%. The dotted line indicates equiactivity, i.e., an 80% inhibition of COX-1.

Timothy D. Warner, et al. Proc Natl Acad Sci U S A. 1999 June 22;96(13):7563-7568.
2.
Figure 3

Figure 3. From: Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis.

Determinable log [IC80 ratio (WBA-COX-2/COX-1)] for all agents assayed (see Table 1). The “0 line” indicates equipotency, i.e., an IC80 ratio of 1. Italics indicate compounds with very low potency.

Timothy D. Warner, et al. Proc Natl Acad Sci U S A. 1999 June 22;96(13):7563-7568.
3.
Figure 2

Figure 2. From: Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis.

The effects of diisopropyl fluorophosphate (A), L-745,337 (B), NS398 (C), and rofecoxib (D) on the activity of COX-1 (solid line), WBA-COX-2 (short dashed line), and WHMA-COX-2 (long dashed line). Results are expressed as percent of control and are represented as mean ± SEM. (n = 5–8).

Timothy D. Warner, et al. Proc Natl Acad Sci U S A. 1999 June 22;96(13):7563-7568.
4.
Figure 1

Figure 1. From: Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis.

The effects of celecoxib (A), diclofenac (B), etodolac (C), ibuprofen (D), meloxicam (E), and nimesulide (F) on the activity of COX-1 (solid line), WBA-COX-2 (short dashed line), and WHMA-COX-2 (long dashed line). Results are expressed as percent of control and are represented as mean ± SEM. (n = 5–8).

Timothy D. Warner, et al. Proc Natl Acad Sci U S A. 1999 June 22;96(13):7563-7568.

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