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Results: 4

1.
Figure 1

Figure 1. From: Pain-mediated altered absorption and metabolism of ibuprofen: an explanation for decreased serum enantiomer concentration after dental surgery.

Individual serum ibuprofen enantiomer concentration-time curves following oral administration of 200 mg racemic ibuprofen 1 week before (Pre-surgery, control) and at the time of first experienced moderate to severe pain (Post-surgery). S-ibuprofen (○), R-ibuprofen (□).

Fakhreddin Jamali, et al. Br J Clin Pharmacol. 1999 April;47(4):391-396.
2.
Figure 2

Figure 2. From: Pain-mediated altered absorption and metabolism of ibuprofen: an explanation for decreased serum enantiomer concentration after dental surgery.

Individual serum ibuprofen enantiomer concentration-time curves following oral administration of 600 mg racemic ibuprofen 1 week before (Pre-surgery, control) and at the time of first experienced moderate to severe pain (Post-surgery). S-ibuprofen (○), R-ibuprofen (□).

Fakhreddin Jamali, et al. Br J Clin Pharmacol. 1999 April;47(4):391-396.
3.
Figure 4

Figure 4. From: Pain-mediated altered absorption and metabolism of ibuprofen: an explanation for decreased serum enantiomer concentration after dental surgery.

Ratio (S:R) of area under plasma concentration curve-times (AUC) of the pharmacologically active S enantiomer over that of the R enantiomer following either 200 mg or 600 mg racemic ibuprofen 1 week before (Pre-surgery) and at the time of first experienced moderate to severe pain (Post-surgery). P<0.005 for 200 mg and <0.007 for 600 mg data. Horizontal lines represent a ratio of 1 (S=R).

Fakhreddin Jamali, et al. Br J Clin Pharmacol. 1999 April;47(4):391-396.
4.
Figure 3

Figure 3. From: Pain-mediated altered absorption and metabolism of ibuprofen: an explanation for decreased serum enantiomer concentration after dental surgery.

Individual area under serum ibuprofen concentration vs time curves calculated for the first 2 h after oral administration of 200 or 600 mg racemic ibuprofen 1 week before (Pre- surgery, control) and at the time of first experienced moderate to severe pain (Post-surgery). For each dose, patients are identified with same symbol. Means were significantly different for S (P<0.01) and R (P<0.05) after 200 mg and for S (P<0.05) after 600 mg.

Fakhreddin Jamali, et al. Br J Clin Pharmacol. 1999 April;47(4):391-396.

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