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Identification of an unique CXCR4 epitope whose ligation inhibits infection by both CXCR4 and CCR5 tropic human immunodeficiency type-I viruses

Tetsuya Adachi, Reiko Tanaka, Akira Kodama, Mineki Saito, Yoshiaki Takahashi, Aftab A Ansari, Yuetsu Tanaka

Retrovirology. 2011; 8: 84. Published online 2011 October 22. doi: 10.1186/1742-4690-8-84

PMCID:: PMC3239297

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Pattern of expression of vascular endothelial growth factor and its receptors in the ovine choroid plexus during long and short photoperiods

Aleksandra Szczepkowska, Barbara Wąsowska, Przemysław D. Gilun, Christine Lagaraine, Vincent Robert, Laurence Dufourny, Jean-Claude Thiéry, Janina Skipor

Cell Tissue Res. 2012 October; 350(1): 157–166. Published online 2012 May 24. doi: 10.1007/s00441-012-1431-7

PMCID:: PMC3462986

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Select item 32215623.

Trends in Selected Chronic Conditions and Behavioral Risk Factors Among Women of Reproductive Age, Behavioral Risk Factor Surveillance System, 2001-2009

Donald K. Hayes, Amy Z. Fan, Ruben A. Smith, Jennifer M. Bombard

Prev Chronic Dis. 2011 November; 8(6): A120. Published online 2011 October 15.

Correction in:: Prev Chronic Dis. 2012; 9: E01.

PMCID:: PMC3221562

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Select item 27100044.

Rapid and High-Throughput pan-Orthopoxvirus Detection and Identification using PCR and Mass Spectrometry

Mark W. Eshoo, Chris A. Whitehouse, Aysegul Nalca, Scott Zoll, Joseph A. Ecker, Thomas A. Hall, Thuy-Trang D. Pennella, David D. Duncan, Anjali Desai, Emily K. Moradi, Karl Rudnick, Brian Libby, Raymond Ranken, Rangarajan Sampath, Steven A. Hofstadler, David J. Ecker, Lawrence B. Blyn

PLoS One. 2009; 4(7): e6342. Published online 2009 July 22. doi: 10.1371/journal.pone.0006342

PMCID:: PMC2710004

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Yersinia pestis DNA from Skeletal Remains from the 6^th Century AD Reveals Insights into Justinianic Plague

Michaela Harbeck, Lisa Seifert, Stephanie Hänsch, David M. Wagner, Dawn Birdsell, Katy L. Parise, Ingrid Wiechmann, Gisela Grupe, Astrid Thomas, Paul Keim, Lothar Zöller, Barbara Bramanti, Julia M. Riehm, Holger C. Scholz

PLoS Pathog. 2013 May; 9(5): e1003349. Published online 2013 May 2. doi: 10.1371/journal.ppat.1003349

PMCID:: PMC3642051

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Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

Matthew W. Parker, Ping Xu, Xiaobo Li, Craig W. Vander Kooi

J Biol Chem. 2012 March 30; 287(14): 11082–11089. Published online 2012 February 8. doi: 10.1074/jbc.M111.331140

PMCID:: PMC3322888

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Unique Monoclonal Antibody Recognizing the Third Extracellular Loop of CXCR4 Induces Lymphocyte Agglutination and Enhances Human Immunodeficiency Virus Type 1-Mediated Syncytium Formation and Productive Infection

Reiko Tanaka, Atsushi Yoshida, Tsutomu Murakami, Eishi Baba, Julliane Lichtenfeld, Takeru Omori, Tohru Kimura, Naomi Tsurutani, Nobutaka Fujii, Zi-Xuan Wang, Stephen C. Peiper, Naoki Yamamoto, Yuetsu Tanaka

J Virol. 2001 December; 75(23): 11534–11543. doi: 10.1128/JVI.75.23.11534-11543.2001

PMCID:: PMC114740

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AAVrh.10-mediated Genetic Delivery of Bevacizumab to the Pleura to Provide Local Anti-VEGF to Suppress Growth of Metastatic Lung Tumors

Masaki Watanabe, Julie L. Boyer, Ronald G. Crystal

Gene Ther. Author manuscript; available in PMC 2011 February 1.

Published in final edited form as: Gene Ther. 2010 August; 17(8): 1042–1051. Published online 2010 July 1. doi: 10.1038/gt.2010.87

PMCID:: PMC2921016

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Visualization of Allostery in P-Selectin Lectin Domain Using MD Simulations

Shouqin Lü, Yan Zhang, Mian Long

PLoS One. 2010; 5(12): e15417. Published online 2010 December 8. doi: 10.1371/journal.pone.0015417

PMCID:: PMC2999562

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Vandetanib (Zactima, ZD6474) Antagonizes ABCC1- and ABCG2-Mediated Multidrug Resistance by Inhibition of Their Transport Function

Li-sheng Zheng, Fang Wang, Yu-hong Li, Xu Zhang, Li-ming Chen, Yong-ju Liang, Chun-ling Dai, Yan-yan Yan, Li-yang Tao, Yan-jun Mi, An-kui Yang, Kenneth Kin Wah To, Li-wu Fu

PLoS ONE. 2009; 4(4): e5172. Published online 2009 April 23. doi: 10.1371/journal.pone.0005172

PMCID:: PMC2669214

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Surface Sites for Engineering Allosteric Control in Proteins

Jeeyeon Lee, Madhusudan Natarajan, Vishal C. Nashine, Michael Socolich, Tina Vo, William P. Russ, Stephen J. Benkovic, Rama Ranganathan

Science. Author manuscript; available in PMC 2011 April 6.

Published in final edited form as: Science. 2008 October 17; 322(5900): 438–442. doi: 10.1126/science.1159052

PMCID:: PMC3071530

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αvβ3 Integrin Limits the Contribution of Neuropilin-1 to Vascular Endothelial Growth Factor-induced Angiogenesis

Stephen D. Robinson, Louise E. Reynolds, Vassiliki Kostourou, Andrew R. Reynolds, Rita Graça da Silva, Bernardo Tavora, Marianne Baker, John F. Marshall, Kairbaan M. Hodivala-Dilke

J Biol Chem. 2009 December 4; 284(49): 33966–33981. Published online 2009 October 16. doi: 10.1074/jbc.M109.030700

PMCID:: PMC2797167

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Recruitment to the pilot phase of Start2quit – lessons learned

Leanne M Gardner, Hazel Gilbert, Irwin Nazareth

Trials. 2011; 12(Suppl 1): A120. Published online 2011 December 13. doi: 10.1186/1745-6215-12-S1-A120

PMCID:: PMC3287694

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Neural bystander damage by infiltrating virus-infected T cells and the cytotoxic T lymphocytes in HTLV-I-associated neurological disease

Eiji Matsuura, Ryuji Kubota, Yuetsu Tanaka, Hiroshi Takashima, Shuji Izumo

Retrovirology. 2011; 8(Suppl 1): A120. Published online 2011 June 6. doi: 10.1186/1742-4690-8-S1-A120

PMCID:: PMC3112588

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Engineered Nanoparticles in Consumer Products: Understanding a New Ingredient

Rebecca Kessler

Environ Health Perspect. 2011 March; 119(3): A120–A125.

PMCID:: PMC3060016

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Select item 186764816.

Oesophagus posters 442–464

Gut. 2002 April; 50(Suppl 2): a120–a125. doi: 10.1136/gut.50.suppl_2.a120

PMCID:: PMC1867648

Summary PDF–181K

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Visual Contrast Sensitivity: Response

HK Hudnell

Environ Health Perspect. 2002 March; 110(3): A120.

PMCID:: PMC1240782

Summary PDF–488K

Select item 362009218.

The Lyme Disease Debate Host Biodiversity and Human Disease Risk

Sharon Levy

Environ Health Perspect. 2013 April; 121(4): a120–a125. Published online 2013 April 1. doi: 10.1289/ehp.121-a120

PMCID:: PMC3620092

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The primary complement components contained in circulating immune complexes in oligoarticular and polyarticular juvenile idiopathic arthritis patient sera are C1q and C4: evidence of classical complement activation

Brooke E Gilliam, Melinda R Reed, Anil K Chauhan, Amanda Dehlendorf, Sandra Crespo-Pagnussat, Terry L Moore

Pediatr Rheumatol Online J. 2012; 10(Suppl 1): A120. Published online 2012 July 13. doi: 10.1186/1546-0096-10-S1-A120

PMCID:: PMC3402960

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Select item 299560620.

Networks as a Type of Social Entrepreneurship to Advance Population Health

Jane Wei-Skillern

Prev Chronic Dis. 2010 November; 7(6): A120. Published online 2010 October 15.

PMCID:: PMC2995606

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PMC Images search for 10.1289/ehp.119-a120

FIG. 4.

Positions of amino acid L291 and F308 on the crystal structure of LcrV. (A) Positions of residues A120, L164, L291, and F308. L291 is in α-12, and L291 appears to interact with L164 on α-7. F308 on α-12 appears to interact with A120 on α-5. (B) Multiple-sequence alignment of the LcrV homologs in Pseudomonas aeruginosa, Photorhabdus luminescens, and Aeromonas hydrophila. Sequence alignment was performed using T-Coffee, and amino acid sequences of the regions homologous to α-7 and α-12 of LcrV are shown (19). Positions of A120, L164, L291, and F308 are indicated by asterisks.

Structure-Function Analysis of the C-Terminal Domain of LcrV from Yersinia pestis

J Bacteriol. 2007 September;189(18):6734-6739.
Figure 4

The A120 mAb does not affect HIV-1 and HTLV-I production from producer cell lines. The X4 HIV-1_IIIBproducer cell line (Molt-4/IIIB) and the HTLV-I producer cell line (MT-2) cells were cultured in the presence of 10 μg/ml of A120 or control mAb for 3 days. The culture supernatants were assayed for HIV-1 p24 and HTLV-I p24 by standard ELISA.

Identification of an unique CXCR4 epitope whose ligation inhibits infection by both CXCR4 and CCR5 tropic human immunodeficiency type-I viruses

Retrovirology. 2011;8:84-84.
Figure 5

LPS is not involved in the A120 mAb-mediated inhibition of HIV-1 infection. Activated PBMCs infected with R5 HIV-1_JR-FLwere cultured in the presence or absence of LPS (0.1 μg/ml) or the A120 mAb with or without anti-CD14 mAb. After 4 days, syncytium formation and virus production in the culture supernatants were determined microscopically (a) and using a p24 ELISA kit (b), respectively.

Identification of an unique CXCR4 epitope whose ligation inhibits infection by both CXCR4 and CCR5 tropic human immunodeficiency type-I viruses

Retrovirology. 2011;8:84-84.
Fig. 4

Light dependence of product off-rate (A) and cofactor binding (B) in the A120 chimera. In (A), the product dissociation rate (k_off, H₄F) shows a small light dependence in A120 (factor of ~1.3) that is abrogated in the background of the dark-locked C450S mutation. (B), Cofactor binding (K_d, NADPH) shows no light dependence. In both assays, the overall effect of LOV2 domain insertion between positions 120 and 121 in the βF-βG loop is similar to that of the point mutation G121V. Error bars indicate SD.

Surface Sites for Engineering Allosteric Control in Proteins

Science. 2008 October 17;322(5900):438-442.

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