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Figure 3.

CAB box–dependent localization of hTR to CBs. Schematic structure of the hTR gene transfected into HeLa cells is shown. Sequences of the CAB box motifs of the wild-type (hTR) and mutant (hTR-m1 and hTR-m2) RNAs are shown. Altered nucleotides are indicated by lowercase letters. Cells were hybridized with a fluorescent probe complementary to hTR from A346 to A382. CBs were stained with an antibody against p80-coilin. Expression of GFP-fibrillarin visualized both nucleoli and CBs. Nuclei of nontransfected cells are circled. Bars, 10 μm.

Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal

J Cell Biol. 2004 March 1;164(5):647-652.
Figure 11CD8+ and CD20+ lymphocyte depletion delays the generation of neutralizing antibodies in SIVagmVer90-infected AGM.

A neutralizing antibody assay using tissue culture lab-adapted SIV_mac251 was utilized to detect neutralizing Ab in historical control (black symbols) and CD8+ and CD20+ lymphocyte-depleted SIV_agmVer90-infected vervet AGM (A). Impact of delayed appearance of neutralizing Ab on set point viremia in two long-term B cell-depleted animals (A346: B; A13: C).

Inhibition of Adaptive Immune Responses Leads to a Fatal Clinical Outcome in SIV-Infected Pigtailed Macaques but Not Vervet African Green Monkeys

PLoS Pathog. 2009 December;5(12):e1000691.
Figure 2.

In situ localization of endogenous hTR in HeLa cells. HeLa cells were hybridized with a mixture of three fluorescent oligonucleotide probes complementary to hTR from G135 to A174, A346 to A382, and U416 to A449. The U85 scaRNA was detected with an oligonucleotide probe complementary to U85 from U13 to G53. CBs were stained with antibodies directed against p80-coilin or SMN. Nucleoli were visualized by transient expression of GFP-fibrillarin (Dundr et al., 2000). Nuclei were stained with DAPI. Unless indicated otherwise, bars represent 10 μm.

Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal

J Cell Biol. 2004 March 1;164(5):647-652.
Figure 2Only partial depletion of B cells in lymphatic tissues of CD8+ and CD20+ lymphocyte-depleted AGM but not of PTM.

Immunohistochemical (IHC) detection of CD20+ B cells in sequential lymph node biopsies from a representative vervet AGM (A346) collected pre-inoculation (A), one week p.i. (B), and four weeks p.i. (C). Representative IHC staining for CD20 is shown on two PTM with different clinical courses. PTM P27 was representative of the pattern seen in the three PTM that showed efficient depletion of CD20+ B cells at one week p.i. that was irreversible at four weeks p.i. (D, E, and F). PTM P24 only had a partial depletion of CD20+ B cells at one week p.i. and near normal CD20+ B cell levels at four weeks p.i. (G, H, and I).

Inhibition of Adaptive Immune Responses Leads to a Fatal Clinical Outcome in SIV-Infected Pigtailed Macaques but Not Vervet African Green Monkeys

PLoS Pathog. 2009 December;5(12):e1000691.

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