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Select item 62689561.

trans-Caryophyllene, a Natural Sesquiterpene, Causes Tracheal Smooth Muscle Relaxation through Blockade of Voltage-Dependent Ca²⁺ Channels

Leidiane Pinho-da-Silva, Paula Virgínia Mendes-Maia, Taylena Maria do Nascimento Garcia Teófilo, Roseli Barbosa, Vania Marilande Ceccatto, Andrelina Noronha Coelho-de-Souza, Jader Santos Cruz, José Henrique Leal-Cardoso

Molecules. 2012 Oct; 17(10): 11965–11977. Published online 2012 Oct 11. doi: 10.3390/molecules171011965

PMCID:: PMC6268956

Article PDF–690K

Select item 72268392.

Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention

Antonella Di Sotto, Silvia Di Giacomo, Elisabetta Rubini, Alberto Macone, Marco Gulli, Caterina Loredana Mammola, Margherita Eufemi, Romina Mancinelli, Gabriela Mazzanti

Cells. 2020 Apr; 9(4): 858. Published online 2020 Apr 2. doi: 10.3390/cells9040858

PMCID:: PMC7226839

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Select item 20139903.

Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw

R Medeiros, G F Passos, C E Vitor, J Koepp, T L Mazzuco, L F Pianowski, M M Campos, J B Calixto

Br J Pharmacol. 2007 Jul; 151(5): 618–627. Published online 2007 Apr 30. doi: 10.1038/sj.bjp.0707270

PMCID:: PMC2013990

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Select item 65721204.

β-Caryophyllene as a Potential Protective Agent Against Myocardial Injury: The Role of Toll-Like Receptors

Nancy S. Younis, Maged E. Mohamed

Molecules. 2019 May; 24(10): 1929. Published online 2019 May 19. doi: 10.3390/molecules24101929

PMCID:: PMC6572120

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β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties

Klaudyna Fidyt, Anna Fiedorowicz, Leon Strządała, Antoni Szumny

Cancer Med. 2016 Oct; 5(10): 3007–3017. Published online 2016 Sep 30. doi: 10.1002/cam4.816

PMCID:: PMC5083753

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Therapeutic Potential of β-Caryophyllene: A Dietary Cannabinoid in Diabetes and Associated Complications

Hebaallah Mamdouh Hashiesh, M.F. Nagoor Meeran, Charu Sharma, Bassem Sadek, Juma Al Kaabi, Shreesh K. Ojha

Nutrients. 2020 Oct; 12(10): 2963. Published online 2020 Sep 28. doi: 10.3390/nu12102963

PMCID:: PMC7599522

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The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene β-Caryophyllene from the Essential Oil of Aquilaria crassna

Saad S. Dahham, Yasser M. Tabana, Muhammad A. Iqbal, Mohamed B. K. Ahamed, Mohammed O. Ezzat, Aman S. A. Majid, Amin M. S. A. Majid

Molecules. 2015 Jul; 20(7): 11808–11829. Published online 2015 Jun 26. doi: 10.3390/molecules200711808

PMCID:: PMC6331975

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Inhibitory Effects of β-Caryophyllene on Helicobacter pylori Infection In Vitro and In Vivo

Hyun Jun Woo, Ji Yeong Yang, Min Ho Lee, Hyun Woo Kim, Hye Jin Kwon, Min Park, Sung-kyu Kim, So-Young Park, Sa-Hyun Kim, Jong-Bae Kim

Int J Mol Sci. 2020 Feb; 21(3): 1008. Published online 2020 Feb 3. doi: 10.3390/ijms21031008

PMCID:: PMC7037973

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Adaptive laboratory evolution of β-caryophyllene producing Saccharomyces cerevisiae

Avinash Godara, Katy C. Kao

Microb Cell Fact. 2021; 20: 106. Published online 2021 May 27. doi: 10.1186/s12934-021-01598-z

PMCID:: PMC8157465

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Correlation between the Skin Permeation Profile of the Synthetic Sesquiterpene Compounds, Beta-Caryophyllene and Caryophyllene Oxide, and the Antiedematogenic Activity by Topical Application of Nanoemulgels

Patrícia Weimer, Tainá Kreutz, Renata P. Limberger, Rochele C. Rossi, Ádley A. N. de Lima, Valdir F. Veiga, Jr., Bibiana Verlindo de Araújo, Letícia S. Koester

Biomolecules. 2022 Aug; 12(8): 1102. Published online 2022 Aug 10. doi: 10.3390/biom12081102

PMCID:: PMC9405972

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Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation

Rosaria Scandiffio, Federica Geddo, Erika Cottone, Giulia Querio, Susanna Antoniotti, Maria Pia Gallo, Massimo E. Maffei, Patrizia Bovolin

Nutrients. 2020 Nov; 12(11): 3273. Published online 2020 Oct 26. doi: 10.3390/nu12113273

PMCID:: PMC7692661

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Chemical Constituents of the Essential Oil from Ecuadorian Endemic Species Croton ferrugineus and Its Antimicrobial, Antioxidant and α-Glucosidase Inhibitory Activity

Eduardo Valarezo, Génesis Gaona-Granda, Vladimir Morocho, Luis Cartuche, James Calva, Miguel Angel Meneses

Molecules. 2021 Aug; 26(15): 4608. Published online 2021 Jul 29. doi: 10.3390/molecules26154608

PMCID:: PMC8348771

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β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain

Esraa Aly, Maitham A. Khajah, Willias Masocha

Molecules. 2020 Jan; 25(1): 106. Published online 2019 Dec 27. doi: 10.3390/molecules25010106

PMCID:: PMC6983198

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Select item 910439914.

Enhanced Oral Bioavailability of β-Caryophyllene in Healthy Subjects Using the VESIsorb^® Formulation Technology, a Novel Self-Emulsifying Drug Delivery System (SEDDS)

Yvonne Mödinger, Katharina Knaub, Tanita Dharsono, Roland Wacker, Remo Meyrat, M. Hunter Land, Anthony L. Petraglia, Christiane Schön

Molecules. 2022 May; 27(9): 2860. Published online 2022 Apr 30. doi: 10.3390/molecules27092860

PMCID:: PMC9104399

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Select item 485742115.

Engineering Escherichia coli to convert acetic acid to β-caryophyllene

Jianming Yang, Qingjuan Nie

Microb Cell Fact. 2016; 15: 74. Published online 2016 May 5. doi: 10.1186/s12934-016-0475-x

PMCID:: PMC4857421

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Select item 899897916.

Anti-Inflammatory Effect of Beta-Caryophyllene Mediated by the Involvement of TRPV1, BDNF and trkB in the Rat Cerebral Cortex after Hypoperfusion/Reperfusion

Maria Pina Serra, Marianna Boi, Antonella Carta, Elisabetta Murru, Gianfranca Carta, Sebastiano Banni, Marina Quartu

Int J Mol Sci. 2022 Apr; 23(7): 3633. Published online 2022 Mar 26. doi: 10.3390/ijms23073633

PMCID:: PMC8998979

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Select item 802661217.

Beta-caryophyllene inhibits cocaine addiction-related behavior by activation of PPARα and PPARγ: repurposing a FDA-approved food additive for cocaine use disorder

Ewa Galaj, Guo-Hua Bi, Allamar Moore, Kai Chen, Yi He, Eliot Gardner, Zheng-Xiong Xi

Neuropsychopharmacology. 2021 Mar; 46(4): 860–870. Published online 2020 Oct 17. doi: 10.1038/s41386-020-00885-4

PMCID:: PMC8026612

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Select item 689358318.

PipeNig^®-FL, a Fluid Extract of Black Pepper (Piper Nigrum L.) with a High Standardized Content of Trans-β-Caryophyllene, Reduces Lipid Accumulation in 3T3-L1 Preadipocytes and Improves Glucose Uptake in C2C12 Myotubes

Federica Geddo, Rosaria Scandiffio, Susanna Antoniotti, Erika Cottone, Giulia Querio, Massimo E. Maffei, Patrizia Bovolin, Maria Pia Gallo

Nutrients. 2019 Nov; 11(11): 2788. Published online 2019 Nov 15. doi: 10.3390/nu11112788

PMCID:: PMC6893583

Article PDF–1.6M

Select item 857073219.

Identification of the NaCl-responsive metabolites in Citrus roots: A lipidomic and volatomic signature

Myriam Lamine, Mahmoud Gargouri, Ahmed Mliki

Plant Signal Behav. 2020; 15(8): 1777376. Published online 2020 Jun 7. doi: 10.1080/15592324.2020.1777376

PMCID:: PMC8570732

Article PDF–440K

Select item 354107520.

Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae

Codruta Ignea, Fotini A Trikka, Ioannis Kourtzelis, Anagnostis Argiriou, Angelos K Kanellis, Sotirios C Kampranis, Antonios M Makris

Microb Cell Fact. 2012; 11: 162. Published online 2012 Dec 22. doi: 10.1186/1475-2859-11-162

PMCID:: PMC3541075

Article PDF–1.5M

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PMC Images search for (-)-trans-Caryophyllene

Figure 5

trans-Caryophyllene inhibited I_Ba in tracheal smooth muscle cells. (A) Effect of trans-caryophyllene (3 mM) on the I_Ba evoked by a depolarizing test pulse to 10 mV from a holding potential of −70 mV. The dotted line denotes zero current. (B) Time-course of I_Ba blockade caused by trans-caryophyllene. Data were normalized to maximum peak current. (C) Average I_Ba at control (black bar) and after addition of 3 mM trans-caryophyllene (gray bar). Bars represent means ± S.E.M, * p < 0.05. (D) Current-voltage relationships of I_Ba in the presence (closed inverted triangles) and absence (closed circles) of trans-caryophyllene. Error bars represent S.E.M.

trans-Caryophyllene, a Natural Sesquiterpene, Causes Tracheal Smooth Muscle Relaxation through Blockade of Voltage-Dependent Ca2+ Channels

Molecules. 2012 Oct;17(10):11965-11977.
Fig. 1

The structure of trans-caryophyllene (right; http://www.chemspider.com/Chemical-Structure.4444848.html) and various parts of Allium iranicum Wendelbo (left)

Computational insight into the protective mechanism of Allium iranicum Wendelbo. Alliaceae in a mouse model of Staphylococcosis: focus on dietary phytocannabinoid trans-caryophyllene

In Silico Pharmacol. 2021;9(1):17.
Fig. 3

The molecular docking of trans-caryophyllene of Allium iranicum Wendelbo. (in yellow color) against β-toxin, FtsZ, and sortase B enzyme (PDB: 3K55, 3WGL; and 4LFG; in cyan color)

Computational insight into the protective mechanism of Allium iranicum Wendelbo. Alliaceae in a mouse model of Staphylococcosis: focus on dietary phytocannabinoid trans-caryophyllene

In Silico Pharmacol. 2021;9(1):17.
Figure 3

Representative experimental tracings showing the inhibitory effects of non-cumulative increasing concentrations (0.005–50 mM) of trans-caryophyllene on the ACh-induced contractions in rat isolated trachea with (EPT(+), Ai; n = 6) and without (EPT(−), Aii; n = 8) intact epithelium. Inverted triangles indicate drug application. (B) Concentration-response curves of the relaxant actions of trans-caryophyllene. Closed triangles represent segments with intact epithelium and closed circles without intact epithelium. Symbols are means ± S.E.M. (C) Average values for relative IC₅₀.

trans-Caryophyllene, a Natural Sesquiterpene, Causes Tracheal Smooth Muscle Relaxation through Blockade of Voltage-Dependent Ca2+ Channels

Molecules. 2012 Oct;17(10):11965-11977.