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Select item 15759541.

GW9662, a potent antagonist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently of PPARγ activation

Jill M Seargent, Elisabeth A Yates, Jason H Gill

Br J Pharmacol. 2004 Dec; 143(8): 933–937. Published online 2004 Nov 8. doi: 10.1038/sj.bjp.0705973

PMCID:: PMC1575954

Article PDF–174K

Select item 62244922.

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

Richard Brust, Jinsai Shang, Jakob Fuhrmann, Sarah A. Mosure, Jared Bass, Andrew Cano, Zahra Heidari, Ian M. Chrisman, Michelle D. Nemetchek, Anne-Laure Blayo, Patrick R. Griffin, Theodore M. Kamenecka, Travis S. Hughes, Douglas J. Kojetin

Nat Commun. 2018; 9: 4687. Published online 2018 Nov 8. doi: 10.1038/s41467-018-07133-w

PMCID:: PMC6224492

Article PDF–2.3M

Select item 46732663.

The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells

Jared Ching, Stephanie Amiridis, Stanley S. Stylli, Andrew R. Bjorksten, Nicole Kountouri, Thomas Zheng, Lucy Paradiso, Rodney B. Luwor, Andrew P. Morokoff, Terence J. O'Brien, Andrew H. Kaye

Oncotarget. 2015 Aug 28; 6(25): 21301–21314. Published online 2015 Jun 3. doi: 10.18632/oncotarget.4019

PMCID:: PMC4673266

Article PDF–5.3M

Select item 39361204.

PPAR-γ Agonist GW1929 But Not Antagonist GW9662 Reduces TBBPA-Induced Neurotoxicity in Primary Neocortical Cells

Anna K. Wojtowicz, Konrad A. Szychowski, Małgorzata Kajta

Neurotox Res. 2014; 25(3): 311–322. Published online 2013 Oct 17. doi: 10.1007/s12640-013-9434-z

PMCID:: PMC3936120

Article PDF–851K

Select item 66775635.

Telmisartan Protects a Microglia Cell Line from LPS Injury Beyond AT1 Receptor Blockade or PPARγ Activation

Abdel G. Elkahloun, Yara Rodriguez, Seham Alaiyed, Erin Wenzel, Juan M. Saavedra

Mol Neurobiol. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Mol Neurobiol. 2019 May; 56(5): 3193–3210. Published online 2018 Aug 13. doi: 10.1007/s12035-018-1300-9

PMCID:: PMC6677563

Article PDF–1.2M

Select item 35851466.

The Role of Peroxisome Proliferator-Activated Receptor γ in Immune Responses to Enteroaggregative Escherichia coli Infection

Casandra W. Philipson, Josep Bassaganya-Riera, Monica Viladomiu, Mireia Pedragosa, Richard L. Guerrant, James K. Roche, Raquel Hontecillas

PLoS One. 2013; 8(2): e57812. Published online 2013 Feb 28. doi: 10.1371/journal.pone.0057812

PMCID:: PMC3585146

Article PDF–805K

Select item 51571067.

Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function

Esi Domi, Stefanie Uhrig, Laura Soverchia, Rainer Spanagel, Anita C. Hansson, Estelle Barbier, Markus Heilig, Roberto Ciccocioppo, Massimo Ubaldi

J Neurosci. 2016 Dec 14; 36(50): 12611–12623. doi: 10.1523/JNEUROSCI.4127-15.2016

PMCID:: PMC5157106

Article PDF–3.0M

Select item 42434978.

Rosiglitazone Causes Cardiotoxicity via Peroxisome Proliferator-Activated Receptor γ-Independent Mitochondrial Oxidative Stress in Mouse Hearts

Huamei He, Hai Tao, Hui Xiong, Sheng Zhong Duan, Francis X. McGowan, Jr., Richard M. Mortensen, James A. Balschi

Toxicol Sci. 2014 Apr 1; 138(2): 468–481. Published online 2014 Jan 21. doi: 10.1093/toxsci/kfu015

PMCID:: PMC4243497

Article PDF–4.0M

Select item 65719659.

Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists

Yuki Utsugi, Hirona Kobuchi, Yukio Kawamura, Ahmed Salahelden Aboelhamd Atito, Masaya Nagao, Hiroko Isoda, Yusaku Miyamae

Molecules. 2019 May; 24(10): 2019. Published online 2019 May 27. doi: 10.3390/molecules24102019

PMCID:: PMC6571965

Article PDF–2.2M

Select item 648440510.

PPARγ inhibition regulates the cell cycle, proliferation and motility of bladder cancer cells

Songtao Cheng, Kaiyu Qian, Yejinpeng Wang, Gang Wang, Xuefeng Liu, Yu Xiao, Xinghuan Wang

J Cell Mol Med. 2019 May; 23(5): 3724–3736. Published online 2019 Mar 25. doi: 10.1111/jcmm.14280

PMCID:: PMC6484405

Article PDF–1.5M

Select item 338879511.

Peroxisome proliferation-related ROS control sets melanocortin tone and feeding in diet-induced obesity

Sabrina Diano, Zhong-Wu Liu, Jin Kwoan Jeong, Marcelo O. Dietrich, Hai-Bin Ruan, Esther Kim, Shigetomo Suyama, Kaitlin Kelly, Erika Gyengesi, Jack L. Arbiser, Denise D. Belsham, David A. Sarruf, Michael W. Schwartz, Anton M. Bennett, Marya Shanabrough, Charles V. Mobbs, Xiaoyong Yang, Xiao-Bing Gao, Tamas L. Horvath

Nat Med. Author manuscript; available in PMC 2012 Jul 3.

Published in final edited form as: Nat Med. 2011 Aug 28; 17(9): 1121–1127. Published online 2011 Aug 28. doi: 10.1038/nm.2421

Correction in:: volume 17 on page 1320

PMCID:: PMC3388795

Article PDF–3.9M

Select item 547000112.

Combination Treatment with PPARγ Ligand and Its Specific Inhibitor GW9662 Downregulates BIS and 14-3-3 Gamma, Inhibiting Stem-Like Properties in Glioblastoma Cells

Chang-Nim Im

Biomed Res Int. 2017; 2017: 5832824. Published online 2017 May 31. doi: 10.1155/2017/5832824

PMCID:: PMC5470001

Article PDF–2.3M

Select item 608285213.

Peroxisome Proliferator-Activated Receptor gamma negatively regulates liver regeneration after partial hepatectomy via the HGF/c-Met/ERK1/2 pathways

Zhangjun Cheng, Lei Liu, Xue-Jun Zhang, Miao Lu, Yang Wang, Volker Assfalg, Melanie Laschinger, Guido von Figura, Yoshiaki Sunami, Christoph W. Michalski, Jörg Kleeff, Helmut Friess, Daniel Hartmann, Norbert Hüser

Sci Rep. 2018; 8: 11894. Published online 2018 Aug 8. doi: 10.1038/s41598-018-30426-5

PMCID:: PMC6082852

Article PDF–4.5M

Select item 565232014.

Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor

Richard Brust, Hua Lin, Jakob Fuhrmann, Alice Asteian, Theodore M. Kamenecka, Douglas J. Kojetin

ACS Chem Biol. Author manuscript; available in PMC 2018 Apr 21.

Published in final edited form as: ACS Chem Biol. 2017 Apr 21; 12(4): 969–978. Published online 2017 Feb 16. doi: 10.1021/acschembio.6b01015

PMCID:: PMC5652320

Article PDF–1.7M

Select item 747145215.

Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ

Zhi-hao Zhang, Jun-qiu He, Ying-yong Zhao, Hua-chao Chen, Ning-hua Tan

Acta Pharmacol Sin. 2020 Mar; 41(3): 373–382. Published online 2019 Nov 8. doi: 10.1038/s41401-019-0319-4

PMCID:: PMC7471452

Article PDF–4.6M

Select item 328176916.

The environmental obesogen tributyltin chloride acts via peroxisome proliferator activated receptor gamma to induce adipogenesis in murine 3T3-L1 preadipocytes

Xia Li, John Ycaza, Bruce Blumberg

J Steroid Biochem Mol Biol. Author manuscript; available in PMC 2012 Oct 1.

Published in final edited form as: J Steroid Biochem Mol Biol. 2011 Oct; 127(1-2): 9–15. Published online 2011 Mar 21. doi: 10.1016/j.jsbmb.2011.03.012