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Human sirtuin 1 (3.5.1.- Histone deacetylases (HDACs))
Assay data:6 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to human SIRT1 by isothermal titration calorimetry
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of SIRT3 by mass spectrometry assay
Assay data:4 Tested
Activation of SIRT2 by mass spectrometry assay
Activation of human SIRT1 expressed in Escherichia coli BL21 by mass spectrometry assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Reduction of blood glucose level in po dosed Zucker fa/fa rat assessed as glucose level after 3 weeks by glucose tolerance test
SummaryPubMed Citation
Effect on body weight in diabetic Lep ob/ob mouse model at 1000 mg/kg, po
Effect on body weight in diabetic Lep ob/ob mouse model at 100 mg/kg, po
Reduction of glucose levels in DIO C57BL/6 mouse model at 5 mg/kg, po during insulin tolerance test
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Reduction of glucose levels in DIO C57BL/6 mouse model at 100 mg/kg, po during insulin tolerance test
Activation of human SIRT1 assessed as decrease in Km of enzyme for acetylated peptide substrate by mass spectrometry assay
Assay data:4 Active, 4 Tested
Reduction in hepatic gluconeogenesis in Zucker fa/fa rat assessed as glucose response by pyruvate tolerance test relative to control
Increase in adipose insulin sensitivity in po dosed Zucker fa/fa rat assessed as plasma free fatty acid level relative to control
Increase in insulin sensitivity in po dosed Zucker fa/fa rat assessed as hepatic glucose production relative to control
Increase in insulin-induced glucose disposal rate into skeletal muscle in po dosed Zucker fa/fa rat relative to control
Increase in glucose disposal rate in po dosed Zucker fa/fa rat relative to control
Increase in glucose infusion rate required to to maintain euglycaemia in po dosed Zucker fa/fa rat relative to control
Reduction of blood insulin level in po dosed Zucker fa/fa rat after 3 weeks by glucose tolerance test
Reduction of blood glucose level in po dosed Zucker fa/fa rat assessed as glucose level after 3 weeks
Reduction of blood glucose level in DIO C57BL/6 mouse model at 500 mg/kg, po after 4 weeks
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