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Acute fatty liver of pregnancy(AFLP)

MedGen UID:
264102
•Concept ID:
C1455728
•
Disease or Syndrome
Synonyms: Acute fatty liver, gestational; AFLP
SNOMED CT: Acute fatty liver of pregnancy (716379000); AFLP - acute fatty liver of pregnancy (716379000)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0016573
Orphanet: ORPHA243367

Definition

Acute fatty liver of pregnancy is a rare but severe complication occurring in the third trimester of pregnancy or in early postpartum period bearing a risk for perinatal and maternal mortality with manifestations of jaundice, rise of hepatic injuries and evolving to acute liver failure and encephalopathy. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute fatty liver of pregnancy
Follow this link to review classifications for Acute fatty liver of pregnancy in Orphanet.

Professional guidelines

PubMed

Thrombocytopenia in pregnancy: Diagnosis and approach to management.
Pishko AM, Levine LD, Cines DB
Blood Rev 2020 Mar;40:100638. Epub 2019 Nov 6 doi: 10.1016/j.blre.2019.100638. PMID: 31757523
Acute Fatty Liver Disease of Pregnancy: Updates in Pathogenesis, Diagnosis, and Management.
Liu J, Ghaziani TT, Wolf JL
Am J Gastroenterol 2017 Jun;112(6):838-846. Epub 2017 Mar 14 doi: 10.1038/ajg.2017.54. PMID: 28291236
Interpretation and management of hepatic abnormalities in pregnancy.
Kia L, Rinella ME
Clin Gastroenterol Hepatol 2013 Nov;11(11):1392-8. Epub 2013 May 23 doi: 10.1016/j.cgh.2013.05.016. PMID: 23707777

Recent clinical studies

Etiology

Obstetric Disorders and Critical Illness.
Griffin KM, Oxford-Horrey C, Bourjeily G
Clin Chest Med 2022 Sep;43(3):471-488. doi: 10.1016/j.ccm.2022.04.008. PMID: 36116815Free PMC Article
Pregnancy-Associated Liver Diseases.
Terrault NA, Williamson C
Gastroenterology 2022 Jul;163(1):97-117.e1. Epub 2022 Mar 8 doi: 10.1053/j.gastro.2022.01.060. PMID: 35276220
Thrombocytopenia in pregnancy: Diagnosis and approach to management.
Pishko AM, Levine LD, Cines DB
Blood Rev 2020 Mar;40:100638. Epub 2019 Nov 6 doi: 10.1016/j.blre.2019.100638. PMID: 31757523
Acute Fatty Liver Disease of Pregnancy: Updates in Pathogenesis, Diagnosis, and Management.
Liu J, Ghaziani TT, Wolf JL
Am J Gastroenterol 2017 Jun;112(6):838-846. Epub 2017 Mar 14 doi: 10.1038/ajg.2017.54. PMID: 28291236
Coagulation disorders in liver disease.
Amitrano L, Guardascione MA, Brancaccio V, Balzano A
Semin Liver Dis 2002 Feb;22(1):83-96. doi: 10.1055/s-2002-23205. PMID: 11928081

Diagnosis

Pregnancy-Associated Liver Diseases.
Terrault NA, Williamson C
Gastroenterology 2022 Jul;163(1):97-117.e1. Epub 2022 Mar 8 doi: 10.1053/j.gastro.2022.01.060. PMID: 35276220
Acute Fatty Liver of Pregnancy.
Nelson DB, Byrne JJ, Cunningham FG
Obstet Gynecol 2021 Mar 1;137(3):535-546. doi: 10.1097/AOG.0000000000004289. PMID: 33543900
Acute Fatty Liver of Pregnancy.
Nelson DB, Byrne JJ, Cunningham FG
Clin Obstet Gynecol 2020 Mar;63(1):152-164. doi: 10.1097/GRF.0000000000000494. PMID: 31725416
HELLP Syndrome: Pathophysiology and Current Therapies.
Wallace K, Harris S, Addison A, Bean C
Curr Pharm Biotechnol 2018;19(10):816-826. doi: 10.2174/1389201019666180712115215. PMID: 29998801
Acute Fatty Liver Disease of Pregnancy: Updates in Pathogenesis, Diagnosis, and Management.
Liu J, Ghaziani TT, Wolf JL
Am J Gastroenterol 2017 Jun;112(6):838-846. Epub 2017 Mar 14 doi: 10.1038/ajg.2017.54. PMID: 28291236

Therapy

Acute Liver Failure.
Ledgerwood C, Villgran V, Mardirossian N, Dumont T, DiSilvio B
Crit Care Nurs Q 2022 Jul-Sep 01;45(3):248-257. doi: 10.1097/CNQ.0000000000000409. PMID: 35617091
Pregnancy-associated hemolytic uremic syndrome.
Alobaidi S, AlDabbagh A, Alamoudi A, Almowarey M, Akl A
Saudi J Kidney Dis Transpl 2020 Nov-Dec;31(6):1180-1188. doi: 10.4103/1319-2442.308326. PMID: 33565429
HELLP Syndrome: Pathophysiology and Current Therapies.
Wallace K, Harris S, Addison A, Bean C
Curr Pharm Biotechnol 2018;19(10):816-826. doi: 10.2174/1389201019666180712115215. PMID: 29998801
Liver Failure in Pregnancy.
Bacak SJ, Thornburg LL
Crit Care Clin 2016 Jan;32(1):61-72. Epub 2015 Oct 9 doi: 10.1016/j.ccc.2015.08.005. PMID: 26600444
Caring for the woman with acute fatty liver of pregnancy.
Holub K, Camune B
J Perinat Neonatal Nurs 2015 Jan-Mar;29(1):32-40. doi: 10.1097/JPN.0000000000000076. PMID: 25633398

Prognosis

Acute Fatty Liver of Pregnancy.
Nelson DB, Byrne JJ, Cunningham FG
Clin Obstet Gynecol 2020 Mar;63(1):152-164. doi: 10.1097/GRF.0000000000000494. PMID: 31725416
Treating acute fatty liver of pregnancy with artificial liver support therapy: Systematic review.
Wu Z, Huang P, Gong Y, Wan J, Zou W
Medicine (Baltimore) 2018 Sep;97(38):e12473. doi: 10.1097/MD.0000000000012473. PMID: 30235743Free PMC Article
Acute Fatty Liver Disease of Pregnancy: Updates in Pathogenesis, Diagnosis, and Management.
Liu J, Ghaziani TT, Wolf JL
Am J Gastroenterol 2017 Jun;112(6):838-846. Epub 2017 Mar 14 doi: 10.1038/ajg.2017.54. PMID: 28291236
Liver Failure in Pregnancy.
Bacak SJ, Thornburg LL
Crit Care Clin 2016 Jan;32(1):61-72. Epub 2015 Oct 9 doi: 10.1016/j.ccc.2015.08.005. PMID: 26600444
Massive obstetric haemorrhage.
Bonnar J
Baillieres Best Pract Res Clin Obstet Gynaecol 2000 Feb;14(1):1-18. doi: 10.1053/beog.1999.0060. PMID: 10789257

Clinical prediction guides

FREQUENCY AND SEVERITY OF LIVER INVOLVEMENT IN HYPERTENSIVE DISORDERS OF PREGNANCY.
Oliveira JC, Codes L, Lucca MMFB, Soares MAP, Lyrio L, Bittencourt PL
Arq Gastroenterol 2022 Jul-Sep;59(3):340-344. doi: 10.1590/S0004-2803.202203000-62. PMID: 36102429
Comparing acute fatty liver of pregnancy from hemolysis, elevated liver enzymes, and low platelets syndrome.
Byrne JJ, Seasely A, Nelson DB, Mcintire DD, Cunningham FG
J Matern Fetal Neonatal Med 2022 Apr;35(7):1352-1362. Epub 2020 Apr 19 doi: 10.1080/14767058.2020.1754790. PMID: 32308076
Acute Fatty Liver of Pregnancy.
Ademiluyi A, Amakye DO, Jackson N, Betty S
Am J Case Rep 2021 Nov 28;22:e933252. doi: 10.12659/AJCR.933252. PMID: 34839346Free PMC Article
Acute Fatty Liver Disease of Pregnancy: Updates in Pathogenesis, Diagnosis, and Management.
Liu J, Ghaziani TT, Wolf JL
Am J Gastroenterol 2017 Jun;112(6):838-846. Epub 2017 Mar 14 doi: 10.1038/ajg.2017.54. PMID: 28291236
Advances in understanding and treating liver diseases during pregnancy: A review.
Kamimura K, Abe H, Kawai H, Kamimura H, Kobayashi Y, Nomoto M, Aoyagi Y, Terai S
World J Gastroenterol 2015 May 7;21(17):5183-90. doi: 10.3748/wjg.v21.i17.5183. PMID: 25954092Free PMC Article

Recent systematic reviews

Leptospirosis in pregnancy: A systematic review.
Selvarajah S, Ran S, Roberts NW, Nair M
PLoS Negl Trop Dis 2021 Sep;15(9):e0009747. Epub 2021 Sep 14 doi: 10.1371/journal.pntd.0009747. PMID: 34520461Free PMC Article
Treating acute fatty liver of pregnancy with artificial liver support therapy: Systematic review.
Wu Z, Huang P, Gong Y, Wan J, Zou W
Medicine (Baltimore) 2018 Sep;97(38):e12473. doi: 10.1097/MD.0000000000012473. PMID: 30235743Free PMC Article
Effect of caesarean section on maternal and foetal outcomes in acute fatty liver of pregnancy: a systematic review and meta-analysis.
Wang HY, Jiang Q, Shi H, Xu YQ, Shi AC, Sun YL, Li J, Ning Q, Shen GX
Sci Rep 2016 Jul 8;6:28826. doi: 10.1038/srep28826. PMID: 27387594Free PMC Article

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