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Gestational trophoblastic neoplasm

MedGen UID:
210107
•Concept ID:
C1135868
•
Neoplastic Process
Synonyms: Gestational Trophoblastic Neoplasia; Gestational Trophoblastic Neoplasm; Gestational Trophoblastic Neoplasms; Neoplasia, Gestational Trophoblastic; Neoplasm, Gestational Trophoblastic; Neoplasms, Gestational Trophoblastic; Trophoblastic Neoplasia, Gestational; Trophoblastic Neoplasm, Gestational; Trophoblastic Neoplasms, Gestational
SNOMED CT: Persistent trophoblastic disease (609519004); Gestational trophoblastic neoplasia (609517002); Persistent gestational trophoblastic disease (609519004); Gestational trophoblastic neoplasia (609519004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018944
Orphanet: ORPHA59305

Definition

Disorder characterised by abnormal proliferation of trophoblasts during pregnancy, of a type which is invasive or metastatic. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGestational trophoblastic neoplasm
Follow this link to review classifications for Gestational trophoblastic neoplasm in Orphanet.

Professional guidelines

PubMed

Analysis of the Outcome of Treatment of Brain Metastases from Malignant Trophoblastic Tumours and Risk Factors for Prognosis during Pregnancy.
Wang A, Zhang H
Contrast Media Mol Imaging 2022;2022:3932460. Epub 2022 Aug 11 doi: 10.1155/2022/3932460. PMID: 36017013Free PMC Article
Treatment results of the second-line chemotherapy regimen for patients with low-risk gestational trophoblastic neoplasia treated with 5-day methotrexate and 5-day etoposide.
Kanno T, Matsui H, Akizawa Y, Usui H, Shozu M
J Gynecol Oncol 2018 Nov;29(6):e89. doi: 10.3802/jgo.2018.29.e89. PMID: 30207097Free PMC Article
The role of color Doppler flow in the management of nonmetastatic gestational trophoblastic disease.
Tepper R, Shulman A, Altaras M, Goldberger S, Maymon R, Holzinger M, Beyth Y
Gynecol Obstet Invest 1994;38(1):14-7. doi: 10.1159/000292436. PMID: 7959318

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gestational Trophoblastic Neoplasia, 2022

Recent clinical studies

Etiology

Claudin-6 enhances the malignant progression of gestational trophoblastic neoplasm by promoting proliferation and metastasis.
Wu Q, Peng M, Lv C, Chen L, Mao X, Lin T, Sun P, Wang Y
Clin Transl Oncol 2023 Apr;25(4):1114-1123. Epub 2022 Dec 5 doi: 10.1007/s12094-022-03021-4. PMID: 36471225
The efficacy evaluation of initial chemotherapy for high-risk gestational trophoblastic neoplasm.
Li Y, Chen D, Yu H, Xia R, Zhang X, Zheng W
Curr Probl Cancer 2022 Jun;46(3):100861. Epub 2022 Mar 29 doi: 10.1016/j.currproblcancer.2022.100861. PMID: 35421635
Gestational trophoblastic neoplasia: Novelties and challenges.
Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Whole transcriptome analysis of gestational trophoblastic neoplasms reveals altered PI3K signaling pathway in epithelioid trophoblastic tumor.
Cho EJ, Chun SM, Park H, Sung CO, Kim KR
Gynecol Oncol 2020 Apr;157(1):151-160. Epub 2020 Jan 15 doi: 10.1016/j.ygyno.2019.09.022. PMID: 31954539
Gestational trophoblastic disease: an overview.
Monchek R, Wiedaseck S
J Midwifery Womens Health 2012 May-Jun;57(3):255-9. Epub 2012 May 15 doi: 10.1111/j.1542-2011.2012.00177.x. PMID: 22587615

Diagnosis

Gestational trophoblastic neoplasia: Novelties and challenges.
Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Differential expression of SALL4 in CTCs derived from hydatidiform moles and gestational trophoblastic neoplasms.
Xu D, Feng F, Pei Y, Zhang Y, Wu Y, Guo Y, Cui W
Am J Reprod Immunol 2020 May;83(5):e13233. Epub 2020 Apr 16 doi: 10.1111/aji.13233. PMID: 32187420
Serum angiogenesis profile in gestational trophoblastic neoplasm using multiplex immunoassay.
Banach P, Dereziński P, Matysiak J, Horała A, Swiatly A, Jasiński P, Kokot ZJ, Nowak-Markwitz E
Life Sci 2018 Oct 15;211:25-30. Epub 2018 Sep 6 doi: 10.1016/j.lfs.2018.08.070. PMID: 30195618
Gestational trophoblastic disease: an overview.
Monchek R, Wiedaseck S
J Midwifery Womens Health 2012 May-Jun;57(3):255-9. Epub 2012 May 15 doi: 10.1111/j.1542-2011.2012.00177.x. PMID: 22587615
Placental site trophoblastic tumor.
Behtash N, Karimi Zarchi M
J Cancer Res Clin Oncol 2008 Jan;134(1):1-6. Epub 2007 Aug 16 doi: 10.1007/s00432-007-0208-y. PMID: 17701427

Therapy

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609 Cohort 47) in Patients with Gestational Trophoblastic Neoplasia.
Patel SP, Othus M, Chae YK, Dennis MJ, Gordon S, Mutch D, Samlowski W, Robinson WRR, Sharon E, Ryan C, Lopez G, Plets M, Blanke C, Kurzrock R
Clin Cancer Res 2024 Jan 5;30(1):33-38. doi: 10.1158/1078-0432.CCR-23-2293. PMID: 37882676Free PMC Article
Gestational trophoblastic neoplasm in a patient with end-stage renal failure (ESRF): the challenges and lessons learnt.
Loo KCY, Lim YN, Kiu DKL, Sim WW
BMJ Case Rep 2022 May 18;15(5) doi: 10.1136/bcr-2022-249474. PMID: 35584862Free PMC Article
The efficacy evaluation of initial chemotherapy for high-risk gestational trophoblastic neoplasm.
Li Y, Chen D, Yu H, Xia R, Zhang X, Zheng W
Curr Probl Cancer 2022 Jun;46(3):100861. Epub 2022 Mar 29 doi: 10.1016/j.currproblcancer.2022.100861. PMID: 35421635
Role of salvage therapy in chemo resistant or recurrent high-risk gestational trophoblastic neoplasm.
Anantharaju AA, Pallavi VR, Bafna UD, Rathod PS, R VC, K S, Kundargi R
Int J Gynecol Cancer 2019 Mar;29(3):547-553. Epub 2019 Jan 29 doi: 10.1136/ijgc-2018-000050. PMID: 30700567
Resistance to single-agent chemotherapy and its risk factors in low-risk gestational trophoblastic neoplasms.
Mousavi AS, Zamani A, Khorasanizadeh F, Gilani MM, Zendehdel K
J Obstet Gynaecol Res 2015 May;41(5):776-83. Epub 2014 Dec 10 doi: 10.1111/jog.12613. PMID: 25492546

Prognosis

Claudin-6 enhances the malignant progression of gestational trophoblastic neoplasm by promoting proliferation and metastasis.
Wu Q, Peng M, Lv C, Chen L, Mao X, Lin T, Sun P, Wang Y
Clin Transl Oncol 2023 Apr;25(4):1114-1123. Epub 2022 Dec 5 doi: 10.1007/s12094-022-03021-4. PMID: 36471225
The efficacy evaluation of initial chemotherapy for high-risk gestational trophoblastic neoplasm.
Li Y, Chen D, Yu H, Xia R, Zhang X, Zheng W
Curr Probl Cancer 2022 Jun;46(3):100861. Epub 2022 Mar 29 doi: 10.1016/j.currproblcancer.2022.100861. PMID: 35421635
Gestational trophoblastic neoplasia: Novelties and challenges.
Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Differential expression of SALL4 in CTCs derived from hydatidiform moles and gestational trophoblastic neoplasms.
Xu D, Feng F, Pei Y, Zhang Y, Wu Y, Guo Y, Cui W
Am J Reprod Immunol 2020 May;83(5):e13233. Epub 2020 Apr 16 doi: 10.1111/aji.13233. PMID: 32187420
Serum angiogenesis profile in gestational trophoblastic neoplasm using multiplex immunoassay.
Banach P, Dereziński P, Matysiak J, Horała A, Swiatly A, Jasiński P, Kokot ZJ, Nowak-Markwitz E
Life Sci 2018 Oct 15;211:25-30. Epub 2018 Sep 6 doi: 10.1016/j.lfs.2018.08.070. PMID: 30195618

Clinical prediction guides

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609 Cohort 47) in Patients with Gestational Trophoblastic Neoplasia.
Patel SP, Othus M, Chae YK, Dennis MJ, Gordon S, Mutch D, Samlowski W, Robinson WRR, Sharon E, Ryan C, Lopez G, Plets M, Blanke C, Kurzrock R
Clin Cancer Res 2024 Jan 5;30(1):33-38. doi: 10.1158/1078-0432.CCR-23-2293. PMID: 37882676Free PMC Article
Gestational trophoblastic neoplasia: Novelties and challenges.
Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Differential expression of SALL4 in CTCs derived from hydatidiform moles and gestational trophoblastic neoplasms.
Xu D, Feng F, Pei Y, Zhang Y, Wu Y, Guo Y, Cui W
Am J Reprod Immunol 2020 May;83(5):e13233. Epub 2020 Apr 16 doi: 10.1111/aji.13233. PMID: 32187420
Role of salvage therapy in chemo resistant or recurrent high-risk gestational trophoblastic neoplasm.
Anantharaju AA, Pallavi VR, Bafna UD, Rathod PS, R VC, K S, Kundargi R
Int J Gynecol Cancer 2019 Mar;29(3):547-553. Epub 2019 Jan 29 doi: 10.1136/ijgc-2018-000050. PMID: 30700567
Klippel-Trenaunay syndrome and gestational trophoblastic neoplasm.
Sreenivasan P, Kumar S, Kumar KK
Indian Pediatr 2014 Sep;51(9):745-6. PMID: 25228614

Supplemental Content

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    Clinical resources

    Practice guidelines

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    Curated

    • NCCN, 2022
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gestational Trophoblastic Neoplasia, 2022

    Reviews

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