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Vinblastine response

MedGen UID:
980030
•Concept ID:
CN297643
•
Sign or Symptom
Drug:
vinblastine
MedGen UID:
21862
•Concept ID:
C0042670
•
Pharmacologic Substance
A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04) [from NCI]
vinblastine

Professional guidelines

PubMed

Treatment Strategies for Advanced Classical Hodgkin Lymphoma in the Times of Dacarbazine Shortage.
Torka P, Przespolewski E, Evens AM
JCO Oncol Pract 2022 Jul;18(7):491-497. Epub 2022 Mar 7 doi: 10.1200/OP.21.00890. PMID: 35254922
Lymphoma: Diagnosis and Treatment.
Lewis WD, Lilly S, Jones KL
Am Fam Physician 2020 Jan 1;101(1):34-41. PMID: 31894937
Autophagy as a molecular target for cancer treatment.
Kocaturk NM, Akkoc Y, Kig C, Bayraktar O, Gozuacik D, Kutlu O
Eur J Pharm Sci 2019 Jun 15;134:116-137. Epub 2019 Apr 11 doi: 10.1016/j.ejps.2019.04.011. PMID: 30981885

Curated

DailyMed Drug Label, vinblastine, 2014

Recent clinical studies

Etiology

Re-challenging chemotherapy after pembrolizumab in platinum-refractory urothelial carcinoma.
Uchimoto T, Fukushima T, Komura K, Fukuokaya W, Adachi T, Hashimoto T, Yoshizawa A, Nakamura K, Yano Y, Nishimura K, Nishio K, Nakamori K, Iwatani K, Yamamoto S, Urabe F, Mori K, Yanagisawa T, Tsuduki S, Takahara K, Inamoto T, Miki J, Kimura T, Ohno Y, Shiroki R, Egawa S, Azuma H
BJU Int 2023 Apr;131(4):477-485. Epub 2022 Sep 26 doi: 10.1111/bju.15893. PMID: 36098556
Randomized phase III KEYNOTE-045 trial of pembrolizumab versus paclitaxel, docetaxel, or vinflunine in recurrent advanced urothelial cancer: results of >2 years of follow-up.
Fradet Y, Bellmunt J, Vaughn DJ, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Nam K, Frenkl TL, Perini RF, de Wit R, Bajorin DF
Ann Oncol 2019 Jun 1;30(6):970-976. doi: 10.1093/annonc/mdz127. PMID: 31050707Free PMC Article
Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial.
Powles T, Durán I, van der Heijden MS, Loriot Y, Vogelzang NJ, De Giorgi U, Oudard S, Retz MM, Castellano D, Bamias A, Fléchon A, Gravis G, Hussain S, Takano T, Leng N, Kadel EE 3rd, Banchereau R, Hegde PS, Mariathasan S, Cui N, Shen X, Derleth CL, Green MC, Ravaud A
Lancet 2018 Feb 24;391(10122):748-757. Epub 2017 Dec 18 doi: 10.1016/S0140-6736(17)33297-X. PMID: 29268948
A systematic review of vinorelbine for the treatment of breast cancer.
Xu YC, Wang HX, Tang L, Ma Y, Zhang FC
Breast J 2013 Mar-Apr;19(2):180-8. Epub 2013 Jan 16 doi: 10.1111/tbj.12071. PMID: 23320984
Vinflunine.
Frampton JE, Moen MD
Drugs 2010 Jul 9;70(10):1283-93. doi: 10.2165/11204970-000000000-00000. PMID: 20568834

Diagnosis

A novel circadian cycle-related gene signature for prognosis prediction of patients with breast cancer.
Hu Y, Fan S, Zhu Y, Xie X
Medicine (Baltimore) 2023 May 5;102(18):e33718. doi: 10.1097/MD.0000000000033718. PMID: 37144994Free PMC Article
Risk-adapted therapy for advanced-stage Hodgkin lymphoma.
Spinner MA, Advani RH
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):200-206. doi: 10.1182/asheducation-2018.1.200. PMID: 30504311Free PMC Article
Multicenter Phase II Study of Sequential Brentuximab Vedotin and Doxorubicin, Vinblastine, and Dacarbazine Chemotherapy for Older Patients With Untreated Classical Hodgkin Lymphoma.
Evens AM, Advani RH, Helenowski IB, Fanale M, Smith SM, Jovanovic BD, Bociek GR, Klein AK, Winter JN, Gordon LI, Hamlin PA
J Clin Oncol 2018 Oct 20;36(30):3015-3022. Epub 2018 Sep 4 doi: 10.1200/JCO.2018.79.0139. PMID: 30179569
Infantile myofibromatosis.
Larralde M, Ferrari B, Martinez JP, Barbieri MAF, Méndez JH, Casas J
An Bras Dermatol 2017 Nov-Dec;92(6):854-857. doi: 10.1590/abd1806-4841.20175001. PMID: 29364448Free PMC Article
Emerging role of novel therapies in Hodgkin lymphoma: proceed with caution.
Bartlett NL
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):317-323. doi: 10.1182/asheducation-2017.1.317. PMID: 29222273Free PMC Article

Therapy

Incorporating Monoclonal Antibodies into the First-Line Treatment of Classical Hodgkin Lymphoma.
Vassilakopoulos TP, Liaskas A, Pereyra P, Panayiotidis P, Angelopoulou MK, Gallamini A
Int J Mol Sci 2023 Aug 24;24(17) doi: 10.3390/ijms241713187. PMID: 37685994Free PMC Article
A systematic review of vinorelbine for the treatment of breast cancer.
Xu YC, Wang HX, Tang L, Ma Y, Zhang FC
Breast J 2013 Mar-Apr;19(2):180-8. Epub 2013 Jan 16 doi: 10.1111/tbj.12071. PMID: 23320984
Vinflunine.
Frampton JE, Moen MD
Drugs 2010 Jul 9;70(10):1283-93. doi: 10.2165/11204970-000000000-00000. PMID: 20568834
Tubulin-targeting agents.
Hait WN, Rubin E, Goodin S
Cancer Chemother Biol Response Modif 2005;22:35-59. doi: 10.1016/s0921-4410(04)22003-8. PMID: 16110607
Metastatic breast cancer.
Rubens RD
Curr Opin Oncol 1995 Nov;7(6):523-6. doi: 10.1097/00001622-199511000-00008. PMID: 8547400

Prognosis

Retrospective analysis of combination carboplatin and vinblastine for pediatric low-grade glioma.
Nellan A, Wright E, Campbell K, Davies KD, Donson AM, Amani V, Judd A, Hemenway MS, Raybin J, Foreman NK, Rush S, Dorris K
J Neurooncol 2020 Jul;148(3):569-575. Epub 2020 Jun 6 doi: 10.1007/s11060-020-03549-x. PMID: 32506370
Randomized phase III KEYNOTE-045 trial of pembrolizumab versus paclitaxel, docetaxel, or vinflunine in recurrent advanced urothelial cancer: results of >2 years of follow-up.
Fradet Y, Bellmunt J, Vaughn DJ, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Nam K, Frenkl TL, Perini RF, de Wit R, Bajorin DF
Ann Oncol 2019 Jun 1;30(6):970-976. doi: 10.1093/annonc/mdz127. PMID: 31050707Free PMC Article
Randomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC study 30986.
De Santis M, Bellmunt J, Mead G, Kerst JM, Leahy M, Maroto P, Gil T, Marreaud S, Daugaard G, Skoneczna I, Collette S, Lorent J, de Wit R, Sylvester R
J Clin Oncol 2012 Jan 10;30(2):191-9. Epub 2011 Dec 12 doi: 10.1200/JCO.2011.37.3571. PMID: 22162575Free PMC Article
Vinflunine.
Frampton JE, Moen MD
Drugs 2010 Jul 9;70(10):1283-93. doi: 10.2165/11204970-000000000-00000. PMID: 20568834
Advances in vinca-alkaloids: Navelbine.
Marty M, Extra JM, Espie M, Leandri S, Besenval M, Krikorian A
Nouv Rev Fr Hematol (1978) 1989;31(2):77-84. PMID: 2671933

Clinical prediction guides

Oral vinorelbine in young patients with desmoid-type fibromatosis.
Kornreich L, Orbach D, Nicolas N, Brisse HJ, Berlanga P, Defachelles AS, Mansuy L, Verite C, Saumet L, Karanian M, Corradini N
Tumori 2023 Oct;109(5):511-518. Epub 2023 Apr 28 doi: 10.1177/03008916231169806. PMID: 37114926
Re-challenging chemotherapy after pembrolizumab in platinum-refractory urothelial carcinoma.
Uchimoto T, Fukushima T, Komura K, Fukuokaya W, Adachi T, Hashimoto T, Yoshizawa A, Nakamura K, Yano Y, Nishimura K, Nishio K, Nakamori K, Iwatani K, Yamamoto S, Urabe F, Mori K, Yanagisawa T, Tsuduki S, Takahara K, Inamoto T, Miki J, Kimura T, Ohno Y, Shiroki R, Egawa S, Azuma H
BJU Int 2023 Apr;131(4):477-485. Epub 2022 Sep 26 doi: 10.1111/bju.15893. PMID: 36098556
Second-line therapy in bladder cancer.
Bachner M, De Santis M
Curr Opin Urol 2009 Sep;19(5):533-9. doi: 10.1097/MOU.0b013e32832eb473. PMID: 19550334
Chemoresistance in non-small cell lung cancer.
Sève P, Dumontet C
Curr Med Chem Anticancer Agents 2005 Jan;5(1):73-88. doi: 10.2174/1568011053352604. PMID: 15720263
Vinorelbine: a novel vinca alkaloid.
Toso C, Lindley C
Am J Health Syst Pharm 1995 Jun 15;52(12):1287-304; quizz 1340-1. doi: 10.1093/ajhp/52.12.1287. PMID: 7656116

Recent systematic reviews

A systematic review and meta-analysis of neoadjuvant chemotherapy for bladder cancer between ddMVAC and GC regimen.
Liu T, Jiang G
Urol Oncol 2022 May;40(5):195.e19-195.e25. Epub 2021 Dec 20 doi: 10.1016/j.urolonc.2021.11.016. PMID: 34949512
Gemcitabine/cisplatin versus methotrexate/vinblastine/doxorubicin/cisplatin for muscle-invasive bladder cancer: A systematic review and meta-analysis.
Yu C, Hequn C, Jinbo C, Feng Z, Xiongbing Z, Jian D
J Cancer Res Ther 2018 Oct-Dec;14(6):1260-1265. doi: 10.4103/0973-1482.188434. PMID: 30488841
Chemotherapy with or without estramustine for treatment of castration-resistant prostate cancer: A systematic review and meta-analysis.
Qin Z, Li X, Zhang J, Tang J, Han P, Xu Z, Yu Y, Yang C, Wang C, Xu T, Xu Z, Zou Q
Medicine (Baltimore) 2016 Sep;95(39):e4801. doi: 10.1097/MD.0000000000004801. PMID: 27684806Free PMC Article
Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer: A Systematic Review and Two-Step Meta-Analysis.
Yin M, Joshi M, Meijer RP, Glantz M, Holder S, Harvey HA, Kaag M, Fransen van de Putte EE, Horenblas S, Drabick JJ
Oncologist 2016 Jun;21(6):708-15. Epub 2016 Apr 6 doi: 10.1634/theoncologist.2015-0440. PMID: 27053504Free PMC Article
A systematic review of vinorelbine for the treatment of breast cancer.
Xu YC, Wang HX, Tang L, Ma Y, Zhang FC
Breast J 2013 Mar-Apr;19(2):180-8. Epub 2013 Jan 16 doi: 10.1111/tbj.12071. PMID: 23320984

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