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Leukoencephalopathy
This term describes abnormality of the white matter of the cerebrum resulting from damage to the myelin sheaths of nerve cells. [from HPO]
Progressive multifocal leukoencephalopathy
A progressive demyelination within the central nervous system associated with reactivation of a latent JC virus infection. [from NCI]
Demyelinating disease
A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase travelling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others. [from NCI]
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