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Brucellosis

MedGen UID:
674
•Concept ID:
C0006309
•
Disease or Syndrome
Synonyms: Cyprus fever; Gibraltar fever; Malta fever; Rock fever; Undulant fever
SNOMED CT: Brucellosis (75702008); Malta fever (75702008); Mediterranean fever (75702008); Undulant fever (75702008); Cyprus fever (75702008); Rock fever (75702008); Gibraltar fever (75702008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005683
Orphanet: ORPHA1304

Definition

Brucellosis is an anthropozoonotic infection, endemic in the Mediterranean region, the Middle East, Latin America and parts of Asia and Africa, that is caused by gram-negative coccobacilli of the genus <i>Brucella</i> transmitted through consumption of unpasteurized dairy products or through direct contact with infected animals, placentas or aborted fetuses. Brucellosis is characterized by fever, fatigue, malaise, headache, anorexia, weight loss, sweating, osteomuscular pain (joint and lumbar pain), and arthritis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBrucellosis
Follow this link to review classifications for Brucellosis in Orphanet.

Professional guidelines

PubMed

Brucellosis: epidemiology, pathogenesis, diagnosis and treatment-a comprehensive review.
Qureshi KA, Parvez A, Fahmy NA, Abdel Hady BH, Kumar S, Ganguly A, Atiya A, Elhassan GO, Alfadly SO, Parkkila S, Aspatwar A
Ann Med 2023;55(2):2295398. Epub 2024 Jan 2 doi: 10.1080/07853890.2023.2295398. PMID: 38165919Free PMC Article
Nano and microparticle drug delivery systems for the treatment of Brucella infections.
Razei A, Javanbakht M, Hajizade A, Heiat M, Zhao S, Aghamollaei H, Saadati M, Khafaei M, Asadi M, Cegolon L, Keihan AH
Biomed Pharmacother 2023 Dec 31;169:115875. Epub 2023 Nov 16 doi: 10.1016/j.biopha.2023.115875. PMID: 37979375
Brucella - Virulence Factors, Pathogenesis and Treatment.
Głowacka P, Żakowska D, Naylor K, Niemcewicz M, Bielawska-Drózd A
Pol J Microbiol 2018 Jun 30;67(2):151-161. doi: 10.21307/pjm-2018-029. PMID: 30015453Free PMC Article

Recent clinical studies

Etiology

Equine Brucellosis: Current Understanding and Challenges.
Dorneles EMS, Santana JA, Costa ACTRB, Junqueira DG Júnior, Heinemann MB, Lage AP
J Equine Vet Sci 2023 Aug;127:104298. Epub 2023 Apr 16 doi: 10.1016/j.jevs.2023.104298. PMID: 37072072
A one-health review on brucellosis in the United States.
Pinn-Woodcock T, Frye E, Guarino C, Franklin-Guild R, Newman AP, Bennett J, Goodrich EL
J Am Vet Med Assoc 2023 Apr 1;261(4):451-462. Epub 2023 Mar 1 doi: 10.2460/javma.23.01.0033. PMID: 36862545
Neurobrucellosis: Brief Review.
Bouferraa Y, Bou Zerdan M, Hamouche R, Azar E, Afif C, Jabbour R
Neurologist 2021 Nov 4;26(6):248-252. doi: 10.1097/NRL.0000000000000348. PMID: 34734902
A review of the immunopathogenesis of Brucellosis.
Amjadi O, Rafiei A, Mardani M, Zafari P, Zarifian A
Infect Dis (Lond) 2019 May;51(5):321-333. Epub 2019 Feb 18 doi: 10.1080/23744235.2019.1568545. PMID: 30773082
The new global map of human brucellosis.
Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV
Lancet Infect Dis 2006 Feb;6(2):91-9. doi: 10.1016/S1473-3099(06)70382-6. PMID: 16439329

Diagnosis

Brucellosis.
Crecelius EM, Burnett MW
J Spec Oper Med 2021 Summer;21(2):98-99. doi: 10.55460/QMQR-TI7J. PMID: 34105131
Bovine brucellosis - a comprehensive review.
Khurana SK, Sehrawat A, Tiwari R, Prasad M, Gulati B, Shabbir MZ, Chhabra R, Karthik K, Patel SK, Pathak M, Iqbal Yatoo M, Gupta VK, Dhama K, Sah R, Chaicumpa W
Vet Q 2021 Jan 1;41(1):61-88. doi: 10.1080/01652176.2020.1868616. PMID: 33353489Free PMC Article
A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China.
Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K
Biomed Res Int 2018;2018:5712920. Epub 2018 Apr 22 doi: 10.1155/2018/5712920. PMID: 29850535Free PMC Article
Spinal brucellosis.
Tali ET, Koc AM, Oner AY
Neuroimaging Clin N Am 2015 May;25(2):233-45. doi: 10.1016/j.nic.2015.01.004. PMID: 25952175
Human brucellosis.
Franco MP, Mulder M, Gilman RH, Smits HL
Lancet Infect Dis 2007 Dec;7(12):775-86. doi: 10.1016/S1473-3099(07)70286-4. PMID: 18045560

Therapy

Brucellosis: epidemiology, pathogenesis, diagnosis and treatment-a comprehensive review.
Qureshi KA, Parvez A, Fahmy NA, Abdel Hady BH, Kumar S, Ganguly A, Atiya A, Elhassan GO, Alfadly SO, Parkkila S, Aspatwar A
Ann Med 2023;55(2):2295398. Epub 2024 Jan 2 doi: 10.1080/07853890.2023.2295398. PMID: 38165919Free PMC Article
Research Progress on Brucellosis.
Deng Y, Liu X, Duan K, Peng Q
Curr Med Chem 2019;26(30):5598-5608. doi: 10.2174/0929867325666180510125009. PMID: 29745323
Brucellosis.
Harrison ER, Posada R
Pediatr Rev 2018 Apr;39(4):222-224. doi: 10.1542/pir.2017-0126. PMID: 29610436
Spinal brucellosis.
Tali ET, Koc AM, Oner AY
Neuroimaging Clin N Am 2015 May;25(2):233-45. doi: 10.1016/j.nic.2015.01.004. PMID: 25952175
Canine brucellosis.
Wanke MM
Anim Reprod Sci 2004 Jul;82-83:195-207. doi: 10.1016/j.anireprosci.2004.05.005. PMID: 15271453

Prognosis

Research progress on complications of Brucellosis.
Jin M, Fan Z, Gao R, Li X, Gao Z, Wang Z
Front Cell Infect Microbiol 2023;13:1136674. Epub 2023 Mar 31 doi: 10.3389/fcimb.2023.1136674. PMID: 37065189Free PMC Article
Neurobrucellosis: Brief Review.
Bouferraa Y, Bou Zerdan M, Hamouche R, Azar E, Afif C, Jabbour R
Neurologist 2021 Nov 4;26(6):248-252. doi: 10.1097/NRL.0000000000000348. PMID: 34734902
A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China.
Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K
Biomed Res Int 2018;2018:5712920. Epub 2018 Apr 22 doi: 10.1155/2018/5712920. PMID: 29850535Free PMC Article
What have we learned from brucellosis in the mouse model?
Grilló MJ, Blasco JM, Gorvel JP, Moriyón I, Moreno E
Vet Res 2012 Apr 13;43(1):29. doi: 10.1186/1297-9716-43-29. PMID: 22500859Free PMC Article
Musculoskeletal brucellosis.
Arkun R, Mete BD
Semin Musculoskelet Radiol 2011 Nov;15(5):470-9. Epub 2011 Nov 11 doi: 10.1055/s-0031-1293493. PMID: 22081282

Clinical prediction guides

Brucellosis-associated hepatitis.
Arslan Y, Baran Aİ, Çelik M
Ir J Med Sci 2024 Feb;193(1):149-156. Epub 2023 May 16 doi: 10.1007/s11845-023-03382-x. PMID: 37191870
Ophthalmological findings in brucellosis.
Karakurt Y, Karakeçili F
J Fr Ophtalmol 2023 Sep;46(7):769-775. Epub 2023 Aug 2 doi: 10.1016/j.jfo.2023.02.017. PMID: 37541801
Follow-up outcomes of asymptomatic brucellosis: a systematic review and meta-analysis.
Li F, Du L, Zhen H, Li M, An S, Fan W, Yan Y, Zhao M, Han X, Li Z, Yang H, Zhang C, Guo C, Zhen Q
Emerg Microbes Infect 2023 Dec;12(1):2185464. doi: 10.1080/22221751.2023.2185464. PMID: 36849445Free PMC Article
Association of Brucellosis with Abortion Prevalence in Humans and Animals in Africa: A Review.
Ntirandekura JB, Matemba LE, Kimera SI, Muma JB, Karimuribo ED
Afr J Reprod Health 2018 Sep;22(3):120-136. doi: 10.29063/ajrh2018/v22i3.13. PMID: 30381939
Musculoskeletal brucellosis.
Arkun R, Mete BD
Semin Musculoskelet Radiol 2011 Nov;15(5):470-9. Epub 2011 Nov 11 doi: 10.1055/s-0031-1293493. PMID: 22081282

Recent systematic reviews

Better efficacy of triple antibiotics therapy for human brucellosis: A systematic review and meta-analysis.
Huang S, Wang H, Li F, Du L, Fan W, Zhao M, Zhen H, Yan Y, Lu M, Han X, Li Z, Li M, An S, Zhang X, Zhen Q, Shui T
PLoS Negl Trop Dis 2023 Sep;17(9):e0011590. Epub 2023 Sep 14 doi: 10.1371/journal.pntd.0011590. PMID: 37708094Free PMC Article
Follow-up outcomes of asymptomatic brucellosis: a systematic review and meta-analysis.
Li F, Du L, Zhen H, Li M, An S, Fan W, Yan Y, Zhao M, Han X, Li Z, Yang H, Zhang C, Guo C, Zhen Q
Emerg Microbes Infect 2023 Dec;12(1):2185464. doi: 10.1080/22221751.2023.2185464. PMID: 36849445Free PMC Article
Brucellosis awareness and knowledge in communities worldwide: A systematic review and meta-analysis of 79 observational studies.
Zhang N, Zhou H, Huang DS, Guan P
PLoS Negl Trop Dis 2019 May;13(5):e0007366. Epub 2019 May 2 doi: 10.1371/journal.pntd.0007366. PMID: 31048848Free PMC Article
A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China.
Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K
Biomed Res Int 2018;2018:5712920. Epub 2018 Apr 22 doi: 10.1155/2018/5712920. PMID: 29850535Free PMC Article
Epidemiology of brucellosis in Iran: A comprehensive systematic review and meta-analysis study.
Mirnejad R, Jazi FM, Mostafaei S, Sedighi M
Microb Pathog 2017 Aug;109:239-247. Epub 2017 Jun 7 doi: 10.1016/j.micpath.2017.06.005. PMID: 28602839

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