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Tularemia

MedGen UID:
22520
•Concept ID:
C0041351
•
Disease or Syndrome
Synonyms: Deerfly fever; Francisella tularensis infection; Lemming fever; Ohara disease; Pahvant Valley plague; Rabbit fever; Yatobyo (Japan)
SNOMED CT: Deerfly fever (19265001); Francis' disease (19265001); O'Hara's disease (19265001); Tularemia (19265001); Infection by Francisella tularensis (19265001); Deer fly fever (19265001); Rabbit fever (19265001); Ohara's disease (19265001); Yatobyo (19265001); Pahvant Valley fever (19265001); Pahvant Valley plague (19265001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018077
Orphanet: ORPHA3392

Definition

A rare bacterial infectious disease caused by <i>Francisella tularensis</i> and characterized by six major clinical presentations: ulceroglandular, glandular, oropharyngeal, oculoglandular, pneumonic, or typhoidal, depending on the route of infection. Early flu-like symptoms are common to all forms and are accompanied/followed by either a skin inoculation ulcer with localized lymphadenopathy; isolated lymphadenopathy; chronic pharyngitis with cervical lymphadenopathy; conjunctivitis with localized lymphadenopathy; lung involvement; severe systemic disease with neurological symptoms. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTularemia
Follow this link to review classifications for Tularemia in Orphanet.

Professional guidelines

PubMed

Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Disaster Preparedness: Biological Threats and Treatment Options.
Narayanan N, Lacy CR, Cruz JE, Nahass M, Karp J, Barone JA, Hermes-DeSantis ER
Pharmacotherapy 2018 Feb;38(2):217-234. Epub 2018 Jan 5 doi: 10.1002/phar.2068. PMID: 29236288
Tularemia: epidemiology, diagnosis, and treatment.
Harik NS
Pediatr Ann 2013 Jul;42(7):288-92. doi: 10.3928/00904481-20130619-13. PMID: 23805970

Recent clinical studies

Etiology

Bioterrorism.
Rathjen NA, Shahbodaghi SD
Am Fam Physician 2021 Oct 1;104(4):376-385. PMID: 34652097
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Tularemia during pregnancy.
Ata N, Kılıç S, Övet G, Alataş N, Çelebi B
Infection 2013 Aug;41(4):753-6. Epub 2013 Apr 5 doi: 10.1007/s15010-013-0456-5. PMID: 23559358
Tularemia.
Feldman KA
J Am Vet Med Assoc 2003 Mar 15;222(6):725-30. doi: 10.2460/javma.2003.222.725. PMID: 12675294
Tularemia.
Ellis J, Oyston PC, Green M, Titball RW
Clin Microbiol Rev 2002 Oct;15(4):631-46. doi: 10.1128/CMR.15.4.631-646.2002. PMID: 12364373Free PMC Article

Diagnosis

Francisella tularensis, Tularemia and Serological Diagnosis.
Maurin M
Front Cell Infect Microbiol 2020;10:512090. Epub 2020 Oct 26 doi: 10.3389/fcimb.2020.512090. PMID: 33194778Free PMC Article
Biowarfare and bioterrorism.
Christian MD
Crit Care Clin 2013 Jul;29(3):717-56. doi: 10.1016/j.ccc.2013.03.015. PMID: 23830660Free PMC Article
Tularemia during pregnancy.
Ata N, Kılıç S, Övet G, Alataş N, Çelebi B
Infection 2013 Aug;41(4):753-6. Epub 2013 Apr 5 doi: 10.1007/s15010-013-0456-5. PMID: 23559358
Tularemia.
Feldman KA
J Am Vet Med Assoc 2003 Mar 15;222(6):725-30. doi: 10.2460/javma.2003.222.725. PMID: 12675294
Tularemia.
Ellis J, Oyston PC, Green M, Titball RW
Clin Microbiol Rev 2002 Oct;15(4):631-46. doi: 10.1128/CMR.15.4.631-646.2002. PMID: 12364373Free PMC Article

Therapy

Bioterrorism.
Rathjen NA, Shahbodaghi SD
Am Fam Physician 2021 Oct 1;104(4):376-385. PMID: 34652097
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Tularemia during pregnancy.
Ata N, Kılıç S, Övet G, Alataş N, Çelebi B
Infection 2013 Aug;41(4):753-6. Epub 2013 Apr 5 doi: 10.1007/s15010-013-0456-5. PMID: 23559358
The atypical pneumonias: clinical diagnosis and importance.
Cunha BA
Clin Microbiol Infect 2006 May;12 Suppl 3:12-24. doi: 10.1111/j.1469-0691.2006.01393.x. PMID: 16669925Free PMC Article
Tularemia pneumonia.
Gill V, Cunha BA
Semin Respir Infect 1997 Mar;12(1):61-7. PMID: 9097380

Prognosis

Tick-Borne Diseases.
Eilbert W, Matella A
Emerg Med Clin North Am 2024 May;42(2):287-302. Epub 2024 Feb 29 doi: 10.1016/j.emc.2024.01.004. PMID: 38641392
Human infectious diseases and the changing climate in the Arctic.
Waits A, Emelyanova A, Oksanen A, Abass K, Rautio A
Environ Int 2018 Dec;121(Pt 1):703-713. Epub 2018 Oct 11 doi: 10.1016/j.envint.2018.09.042. PMID: 30317100
Tularemia in Germany-A Re-emerging Zoonosis.
Faber M, Heuner K, Jacob D, Grunow R
Front Cell Infect Microbiol 2018;8:40. Epub 2018 Feb 16 doi: 10.3389/fcimb.2018.00040. PMID: 29503812Free PMC Article
Granulomatous lymphadenitis.
Asano S
J Clin Exp Hematop 2012;52(1):1-16. doi: 10.3960/jslrt.52.1. PMID: 22706525
Tularemia.
Feldman KA
J Am Vet Med Assoc 2003 Mar 15;222(6):725-30. doi: 10.2460/javma.2003.222.725. PMID: 12675294

Clinical prediction guides

Human infectious diseases and the changing climate in the Arctic.
Waits A, Emelyanova A, Oksanen A, Abass K, Rautio A
Environ Int 2018 Dec;121(Pt 1):703-713. Epub 2018 Oct 11 doi: 10.1016/j.envint.2018.09.042. PMID: 30317100
Tularemia in Germany-A Re-emerging Zoonosis.
Faber M, Heuner K, Jacob D, Grunow R
Front Cell Infect Microbiol 2018;8:40. Epub 2018 Feb 16 doi: 10.3389/fcimb.2018.00040. PMID: 29503812Free PMC Article
Granulomatous lymphadenitis.
Asano S
J Clin Exp Hematop 2012;52(1):1-16. doi: 10.3960/jslrt.52.1. PMID: 22706525
The atypical pneumonias: clinical diagnosis and importance.
Cunha BA
Clin Microbiol Infect 2006 May;12 Suppl 3:12-24. doi: 10.1111/j.1469-0691.2006.01393.x. PMID: 16669925Free PMC Article
Zoonoses.
Goscienski PJ
Pediatr Infect Dis 1983 Jan-Feb;2(1):69-81. doi: 10.1097/00006454-198301000-00018. PMID: 6340080

Recent systematic reviews

Systematic Review of Tularemia During Pregnancy.
Fleck-Derderian S, Davis KM, Winberg J, Nelson CA, Meaney-Delman D
Clin Infect Dis 2024 Jan 31;78(Suppl 1):S47-S54. doi: 10.1093/cid/ciad686. PMID: 38294114
Systematic Review: Clinical Features, Antimicrobial Treatment, and Outcomes of Human Tularemia, 1993-2023.
Nelson CA, Winberg J, Bostic TD, Davis KM, Fleck-Derderian S
Clin Infect Dis 2024 Jan 31;78(Suppl 1):S15-S28. doi: 10.1093/cid/ciad736. PMID: 38294108
The prevalence of Q fever in the Eastern Mediterranean region: a systematic review and meta-analysis.
Ahmadinezhad M, Mounesan L, Doosti-Irani A, Behzadi MY
Epidemiol Health 2022;44:e2022097. Epub 2022 Oct 28 doi: 10.4178/epih.e2022097. PMID: 36317399Free PMC Article
Laboratory Methods for Detection of Infectious Agents and Serological Response in Humans With Tick-Borne Infections: A Systematic Review of Evaluations Based on Clinical Patient Samples.
Henningsson AJ, Aase A, Bavelaar H, Flottorp S, Forsberg P, Kirkehei I, Lövmar M, Nilsson K, Nyman D, Ornstein K, Sjöwall J, Skogman BH, Tjernberg I, Aaberge I
Front Public Health 2021;9:580102. Epub 2021 Sep 20 doi: 10.3389/fpubh.2021.580102. PMID: 34616701Free PMC Article
Seroprevalence of Q fever among human and animal in Iran; A systematic review and meta-analysis.
Mohabbati Mobarez A, Bagheri Amiri F, Esmaeili S
PLoS Negl Trop Dis 2017 Apr;11(4):e0005521. Epub 2017 Apr 10 doi: 10.1371/journal.pntd.0005521. PMID: 28394889Free PMC Article

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