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BK-virus nephropathy(BKN)

MedGen UID:
352157
•Concept ID:
C1697878
•
Disease or Syndrome
Synonyms: BKN; Nephropathy from BK virus; Polyomavirus nephropathy
SNOMED CT: Kidney disease caused by BK polyomavirus (713886006); Nephropathy caused by BK polyomavirus (713886006); BK virus nephropathy (713886006)
 
Monarch Initiative: MONDO:0022529

Professional guidelines

PubMed

IVIg therapy in the management of BK virus infections in pediatric kidney transplant patients.
Mosca M, Bacchetta J, Chamouard V, Rascle P, Dubois V, Paul S, Mekki Y, Picard C, Bertholet-Thomas A, Ranchin B, Sellier-Leclerc AL
Arch Pediatr 2023 Apr;30(3):165-171. Epub 2023 Mar 10 doi: 10.1016/j.arcped.2023.01.005. PMID: 36907728
Current Status, Prevention and Treatment of BK Virus Nephropathy.
Kurašová E, Štěpán J, Krejčí K, Mrázek F, Sauer P, Janečková J, Tichý T
Acta Medica (Hradec Kralove) 2022;65(4):119-124. doi: 10.14712/18059694.2023.1. PMID: 36942701
Polyomavirus nephropathy: morphology, pathophysiology, and clinical management.
Nickeleit V, Singh HK, Mihatsch MJ
Curr Opin Nephrol Hypertens 2003 Nov;12(6):599-605. doi: 10.1097/00041552-200311000-00005. PMID: 14564196

Recent clinical studies

Etiology

BK virus-induced renal allograft nephropathy.
Krejci K, Tichy T, Bednarikova J, Zamboch K, Zadrazil J
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2018 Sep;162(3):165-177. Epub 2018 May 16 doi: 10.5507/bp.2018.018. PMID: 29765170
BK and Other Polyomaviruses in Kidney Transplantation.
Trofe-Clark J, Sawinski D
Semin Nephrol 2016 Sep;36(5):372-385. doi: 10.1016/j.semnephrol.2016.05.014. PMID: 27772622
BK Virus in Kidney Transplant: Current Concepts, Recent Advances, and Future Directions.
Sharma R, Tzetzo S, Patel S, Zachariah M, Sharma S, Melendy T
Exp Clin Transplant 2016 Aug;14(4):377-84. Epub 2016 Jun 3 doi: 10.6002/ect.2016.0030. PMID: 27267780
BK virus nephropathy in renal transplant recipients.
Jamboti JS
Nephrology (Carlton) 2016 Aug;21(8):647-54. doi: 10.1111/nep.12728. PMID: 26780694
Leflunomide in renal transplantation.
Chon WJ, Josephson MA
Expert Rev Clin Immunol 2011 May;7(3):273-81. doi: 10.1586/eci.11.20. PMID: 21595593

Diagnosis

Urine Exosomal bkv-miR-B1-5p and BK Virus Nephropathy in Kidney Transplant Recipients.
Jung SW, Cho WH, Seo JW, Kim YG, Moon JY, Kim JS, Kim CD, Chung BH, Park JB, Kim YH, Lee SH
J Infect Dis 2023 May 12;227(10):1185-1193. doi: 10.1093/infdis/jiac440. PMID: 36374933Free PMC Article
BK Virus Nephropathy in Kidney Transplantation: A State-of-the-Art Review.
Kant S, Dasgupta A, Bagnasco S, Brennan DC
Viruses 2022 Jul 25;14(8) doi: 10.3390/v14081616. PMID: 35893681Free PMC Article
BK virus-induced renal allograft nephropathy.
Krejci K, Tichy T, Bednarikova J, Zamboch K, Zadrazil J
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2018 Sep;162(3):165-177. Epub 2018 May 16 doi: 10.5507/bp.2018.018. PMID: 29765170
BK and Other Polyomaviruses in Kidney Transplantation.
Trofe-Clark J, Sawinski D
Semin Nephrol 2016 Sep;36(5):372-385. doi: 10.1016/j.semnephrol.2016.05.014. PMID: 27772622
BK virus nephropathy in renal transplant recipients.
Jamboti JS
Nephrology (Carlton) 2016 Aug;21(8):647-54. doi: 10.1111/nep.12728. PMID: 26780694

Therapy

Urine Exosomal bkv-miR-B1-5p and BK Virus Nephropathy in Kidney Transplant Recipients.
Jung SW, Cho WH, Seo JW, Kim YG, Moon JY, Kim JS, Kim CD, Chung BH, Park JB, Kim YH, Lee SH
J Infect Dis 2023 May 12;227(10):1185-1193. doi: 10.1093/infdis/jiac440. PMID: 36374933Free PMC Article
BK Virus Nephropathy in Kidney Transplantation: A State-of-the-Art Review.
Kant S, Dasgupta A, Bagnasco S, Brennan DC
Viruses 2022 Jul 25;14(8) doi: 10.3390/v14081616. PMID: 35893681Free PMC Article
BK virus-induced renal allograft nephropathy.
Krejci K, Tichy T, Bednarikova J, Zamboch K, Zadrazil J
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2018 Sep;162(3):165-177. Epub 2018 May 16 doi: 10.5507/bp.2018.018. PMID: 29765170
BK and Other Polyomaviruses in Kidney Transplantation.
Trofe-Clark J, Sawinski D
Semin Nephrol 2016 Sep;36(5):372-385. doi: 10.1016/j.semnephrol.2016.05.014. PMID: 27772622
BK virus nephropathy in renal transplant recipients.
Jamboti JS
Nephrology (Carlton) 2016 Aug;21(8):647-54. doi: 10.1111/nep.12728. PMID: 26780694

Prognosis

Urine Exosomal bkv-miR-B1-5p and BK Virus Nephropathy in Kidney Transplant Recipients.
Jung SW, Cho WH, Seo JW, Kim YG, Moon JY, Kim JS, Kim CD, Chung BH, Park JB, Kim YH, Lee SH
J Infect Dis 2023 May 12;227(10):1185-1193. doi: 10.1093/infdis/jiac440. PMID: 36374933Free PMC Article
Urinary Cell mRNA Profiles Predictive of Human Kidney Allograft Status.
Lubetzky ML, Salinas T, Schwartz JE, Suthanthiran M
Clin J Am Soc Nephrol 2021 Oct;16(10):1565-1577. Epub 2021 Apr 27 doi: 10.2215/CJN.14010820. PMID: 33906907Free PMC Article
BK Virus Nephropathy: Histological Evolution by Sequential Pathology.
Nankivell BJ, Renthawa J, Sharma RN, Kable K, O'Connell PJ, Chapman JR
Am J Transplant 2017 Aug;17(8):2065-2077. Epub 2017 May 5 doi: 10.1111/ajt.14292. PMID: 28371308
Biopsy-Proven BK Virus-Associated Nephropathy: Clinico-Pathologic Correlations.
Jahdali S, Al Oudah N, Alsaad KO, Kfoury H, Qurashi S, Al Sayyari A
Exp Clin Transplant 2017 Jun;15(3):289-294. Epub 2017 Jan 30 doi: 10.6002/ect.2016.0093. PMID: 28137206
BK Virus in Kidney Transplant: Current Concepts, Recent Advances, and Future Directions.
Sharma R, Tzetzo S, Patel S, Zachariah M, Sharma S, Melendy T
Exp Clin Transplant 2016 Aug;14(4):377-84. Epub 2016 Jun 3 doi: 10.6002/ect.2016.0030. PMID: 27267780

Clinical prediction guides

Comparative Study of Intravenous Immunoglobulin and Leflunomide Combination Therapy With Intravenous Immunoglobulin Single Therapy in Kidney Transplant Patients With BK Virus Infection: Single-Center Clinical Trial.
Rasaei N, Malekmakan L, Gholamabbas G, Abdizadeh P
Exp Clin Transplant 2023 Oct;21(10):814-819. doi: 10.6002/ect.2023.0071. PMID: 37965956
Urine Exosomal bkv-miR-B1-5p and BK Virus Nephropathy in Kidney Transplant Recipients.
Jung SW, Cho WH, Seo JW, Kim YG, Moon JY, Kim JS, Kim CD, Chung BH, Park JB, Kim YH, Lee SH
J Infect Dis 2023 May 12;227(10):1185-1193. doi: 10.1093/infdis/jiac440. PMID: 36374933Free PMC Article
BK Virus Nephropathy: Histological Evolution by Sequential Pathology.
Nankivell BJ, Renthawa J, Sharma RN, Kable K, O'Connell PJ, Chapman JR
Am J Transplant 2017 Aug;17(8):2065-2077. Epub 2017 May 5 doi: 10.1111/ajt.14292. PMID: 28371308
Biopsy-Proven BK Virus-Associated Nephropathy: Clinico-Pathologic Correlations.
Jahdali S, Al Oudah N, Alsaad KO, Kfoury H, Qurashi S, Al Sayyari A
Exp Clin Transplant 2017 Jun;15(3):289-294. Epub 2017 Jan 30 doi: 10.6002/ect.2016.0093. PMID: 28137206
BK Virus in Kidney Transplant: Current Concepts, Recent Advances, and Future Directions.
Sharma R, Tzetzo S, Patel S, Zachariah M, Sharma S, Melendy T
Exp Clin Transplant 2016 Aug;14(4):377-84. Epub 2016 Jun 3 doi: 10.6002/ect.2016.0030. PMID: 27267780

Recent systematic reviews

Native kidney BK virus nephropathy, a systematic review.
Shah A, Kumar V, Palmer MB, Trofe-Clark J, Laskin B, Sawinski D, Hogan JJ
Transpl Infect Dis 2019 Aug;21(4):e13083. Epub 2019 May 11 doi: 10.1111/tid.13083. PMID: 30907978Free PMC Article

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