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Legionnaires disease

MedGen UID:: 9705
•Concept ID:: C0023241
•: Disease or Syndrome

Synonyms:	Legionnaire's disease; Legionnaires' disease
SNOMED CT:	Legionella pneumonia (195889001); Legionnaire's disease (195889001); Legionnaires' disease (195889001); Legionnaires disease (195889001); Infection caused by Legionella pneumophilia (269574000); Infection by Legionella pneumophilia (269574000)

Related gene: Gene(s) associated with related conditions. For conditions in a hierarchy, the parent condition will list the genes associated with the children conditions.	TLR5

Monarch Initiative:	MONDO:0005824

Definition

A pneumonia caused by Legionella pneumophila and other Legionella species, which is characterized by fever, cough, progressive respiratory distress, and which is often accompanied by extrapulmonary manifestations. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLegionella infection
- CROGVLegionnaires disease
  - CROGVLegionnaire disease, susceptibility to
- CROGVPontiac fever

Clinical finding
- Finding by Cause
  - Infection
    - Bacterial Infections and Mycoses
      - Bacterial infectious disease
        Bacterial pneumonia
        Legionnaires disease
        Legionnaire disease, susceptibility to

Professional guidelines

PubMed

Recreational Waterborne Illnesses: Recognition, Treatment, and Prevention.

Perkins A, Trimmier M
Am Fam Physician 2017 May 1;95(9):554-560. PMID: 28671392

Epidemiology and clinical management of Legionnaires' disease.

Phin N, Parry-Ford F, Harrison T, Stagg HR, Zhang N, Kumar K, Lortholary O, Zumla A, Abubakar I
Lancet Infect Dis 2014 Oct;14(10):1011-21. Epub 2014 Jun 23 doi: 10.1016/S1473-3099(14)70713-3. PMID: 24970283

Treatment of Legionnaires' disease.

Amsden GW
Drugs 2005;65(5):605-14. doi: 10.2165/00003495-200565050-00003. PMID: 15748096

See all (56)

Recent clinical studies

Etiology

Outbreaks of Legionnaires' Disease and Pontiac Fever 2006-2017.

Hamilton KA, Prussin AJ 2nd, Ahmed W, Haas CN
Curr Environ Health Rep 2018 Jun;5(2):263-271. doi: 10.1007/s40572-018-0201-4. PMID: 29744757

Legionnaires' disease.

Cunha BA, Burillo A, Bouza E
Lancet 2016 Jan 23;387(10016):376-385. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)60078-2. PMID: 26231463

Legionnaires' disease.

Gould D
Nurs Stand 2003 Jul 23-29;17(45):41-4. doi: 10.7748/ns.17.45.41.s55. PMID: 12929345

Legionella infection.

Nguyen ML, Yu VL
Clin Chest Med 1991 Jun;12(2):257-68. PMID: 1855370

Legionnaires' disease.

Kass EH
N Engl J Med 1977 Dec 1;297(22):1229-30. doi: 10.1056/NEJM197712012972209. PMID: 72359

See all (987)

Diagnosis

Legionella prediction score.

Miyashita N
Respir Investig 2024 Mar;62(2):305-306. Epub 2024 Jan 31 doi: 10.1016/j.resinv.2024.01.008. PMID: 38301531

Legionnaires' disease.

Cunha BA, Burillo A, Bouza E
Lancet 2016 Jan 23;387(10016):376-385. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)60078-2. PMID: 26231463

Legionella and Legionnaires' disease: 25 years of investigation.

Fields BS, Benson RF, Besser RE
Clin Microbiol Rev 2002 Jul;15(3):506-26. doi: 10.1128/CMR.15.3.506-526.2002. PMID: 12097254 Free PMC Article

Legionella infection.

Nguyen ML, Yu VL
Clin Chest Med 1991 Jun;12(2):257-68. PMID: 1855370

Legionella infections.

Ching WT, Meyer RD
Infect Dis Clin North Am 1987 Sep;1(3):595-614. PMID: 3332887

See all (1528)

Therapy

Severe Pneumonia Caused by Legionella pneumophila: Differential Diagnosis and Therapeutic Considerations.

Chahin A, Opal SM
Infect Dis Clin North Am 2017 Mar;31(1):111-121. doi: 10.1016/j.idc.2016.10.009. PMID: 28159171 Free PMC Article

Legionnaires' disease.

Cunha BA, Burillo A, Bouza E
Lancet 2016 Jan 23;387(10016):376-385. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)60078-2. PMID: 26231463

Legionellosis.

Pedro-Botet ML, Sabrià M
Semin Respir Crit Care Med 2005 Dec;26(6):625-34. doi: 10.1055/s-2005-925526. PMID: 16388431

Legionella infection.

Nguyen ML, Yu VL
Clin Chest Med 1991 Jun;12(2):257-68. PMID: 1855370

Legionnaires' disease.

Shands KN, Fraser DW
Dis Mon 1980 Dec;27(3):1-59. doi: 10.1016/s0011-5029(80)80010-1. PMID: 7006946

See all (680)

Prognosis

Legionella prediction score.

Miyashita N
Respir Investig 2024 Mar;62(2):305-306. Epub 2024 Jan 31 doi: 10.1016/j.resinv.2024.01.008. PMID: 38301531

Legionella: a reemerging pathogen.

Herwaldt LA, Marra AR
Curr Opin Infect Dis 2018 Aug;31(4):325-333. doi: 10.1097/QCO.0000000000000468. PMID: 29794542

Legionellosis in the occupational setting.

Principe L, Tomao P, Visca P
Environ Res 2017 Jan;152:485-495. Epub 2016 Oct 4 doi: 10.1016/j.envres.2016.09.018. PMID: 27717486

Legionnaires' disease.

Cunha BA, Burillo A, Bouza E
Lancet 2016 Jan 23;387(10016):376-385. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)60078-2. PMID: 26231463

Legionnaires' disease in France.

Campèse C, Descours G, Lepoutre A, Beraud L, Maine C, Che D, Jarraud S
Med Mal Infect 2015 Mar;45(3):65-71. Epub 2015 Feb 24 doi: 10.1016/j.medmal.2015.01.015. PMID: 25722040

See all (479)

Clinical prediction guides

Legionella prediction score.

Miyashita N
Respir Investig 2024 Mar;62(2):305-306. Epub 2024 Jan 31 doi: 10.1016/j.resinv.2024.01.008. PMID: 38301531

Legionellosis in the occupational setting.

Principe L, Tomao P, Visca P
Environ Res 2017 Jan;152:485-495. Epub 2016 Oct 4 doi: 10.1016/j.envres.2016.09.018. PMID: 27717486

An update on Legionella.

Carratalà J, Garcia-Vidal C
Curr Opin Infect Dis 2010 Apr;23(2):152-7. doi: 10.1097/QCO.0b013e328336835b. PMID: 20051846

The atypical pneumonias: clinical diagnosis and importance.

Cunha BA
Clin Microbiol Infect 2006 May;12 Suppl 3:12-24. doi: 10.1111/j.1469-0691.2006.01393.x. PMID: 16669925 Free PMC Article

Legionellosis.

Pedro-Botet ML, Sabrià M
Semin Respir Crit Care Med 2005 Dec;26(6):625-34. doi: 10.1055/s-2005-925526. PMID: 16388431

See all (438)

Recent systematic reviews

Therapeutical strategies in cavitary legionnaires' disease, two cases from the field and a systematic review.

Moretti M, De Boek L, Ilsen B, Demuyser T, Vanderhelst E
Ann Clin Microbiol Antimicrob 2023 Nov 29;22(1):105. doi: 10.1186/s12941-023-00652-5. PMID: 38031167 Free PMC Article

Meteorological conditions and Legionnaires' disease sporadic cases-a systematic review.

Pampaka D, Gómez-Barroso D, López-Perea N, Carmona R, Portero RC
Environ Res 2022 Nov;214(Pt 4):114080. Epub 2022 Aug 11 doi: 10.1016/j.envres.2022.114080. PMID: 35964674

Accuracy of diagnostic tests for Legionnaires' disease: a systematic review.

Cristovam E, Almeida D, Caldeira D, Ferreira JJ, Marques T
J Med Microbiol 2017 Apr;66(4):485-489. doi: 10.1099/jmm.0.000454. PMID: 28463665

Legionnaires' Disease in Hotels and Passenger Ships: A Systematic Review of Evidence, Sources, and Contributing Factors.

Mouchtouri VA, Rudge JW
J Travel Med 2015 Sep-Oct;22(5):325-37. Epub 2015 Jul 29 doi: 10.1111/jtm.12225. PMID: 26220258

An update on Legionella.

Carratalà J, Garcia-Vidal C
Curr Opin Infect Dis 2010 Apr;23(2):152-7. doi: 10.1097/QCO.0b013e328336835b. PMID: 20051846

See all (14)

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Links from PMC

Legionnaires disease

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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Practice guidelines

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