mcm10.L minichromosome maintenance 10 replication initiation factor L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mcm10.L
Official Full Name: minichromosome maintenance 10 replication initiation factor L homeolog
Primary source: Xenbase:XB-GENE-1015396
Locus tag: XELAEV_18017827mg
See related: EnsemblRapid:ENSXLAG00005035727
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mcm10; xmcm10
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Genomic context

Location:: chromosome: 3L

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (87736484..87760280, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (72400489..72424279, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RTEL1 and MCM10 overcome topological stress during vertebrate replication termination.
Title: RTEL1 and MCM10 overcome topological stress during vertebrate replication termination.
the absence of Mcm10 or its phosphorylation by CDK results in instability of replisome proteins on DNA, which is particularly important under conditions of replication stress.
Title: Xenopus Mcm10 is a CDK-substrate required for replication fork stability.
Dna2 co-localizes in foci with RPA and is found in a complex with replication fork components And-1 and Mcm10. Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 and ATM.
Title: Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM.
insight in the action of Mcm10 in the replisome
Title: Solution NMR structure of the C-terminal DNA binding domain of Mcm10 reveals a conserved MCM motif.
Structural basis for DNA binding by replication initiator Mcm10 is reported.
Title: Structural basis for DNA binding by replication initiator Mcm10.
analysis of domain architecture and biochemical characterization of vertebrate Mcm10
Title: Domain architecture and biochemical characterization of vertebrate Mcm10.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nuclear replication fork	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein MCM10 homolog

Names: Mcm10p; minichromosome maintenance complex component 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088578.1 → NP_001082047.1 protein MCM10 homolog

See identical proteins and their annotated locations for NP_001082047.1

Status: PROVISIONAL

Source sequence(s)

AF314535

UniProtKB/Swiss-Prot

Q5EAW4, Q9DEX0

Related

ENSXLAP00005107110.1, ENSXLAT00005109222.1

Conserved Domains (3) summary

pfam04880
Location:104 → 231

NUDE_C; NUDE protein, C-terminal conserved region

pfam09329
Location:373 → 418

zf-primase; Primase zinc finger

pfam09332
Location:515 → 858

Mcm10; Mcm10 replication factor

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

87736484..87760280 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)