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    PRUNE2 prune homolog 2 with BCH domain [ Homo sapiens (human) ]

    Gene ID: 158471, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PRUNE2provided by HGNC
    Official Full Name
    prune homolog 2 with BCH domainprovided by HGNC
    Primary source
    HGNC:HGNC:25209
    See related
    Ensembl:ENSG00000106772 MIM:610691; AllianceGenome:HGNC:25209
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BMCC1; BNIPXL; C9orf65; KIAA0367
    Summary
    The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
    Expression
    Broad expression in prostate (RPKM 10.8), brain (RPKM 9.0) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    9q21.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (76611376..76906114, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (88767783..89062562, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (79226292..79521030, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19963 Neighboring gene peptidylprolyl isomerase A pseudogene 87 Neighboring gene uncharacterized LOC105376095 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:79284679-79285292 Neighboring gene NANOG hESC enhancer GRCh37_chr9:79303428-79303929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28482 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:79398353-79399552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79402243-79402744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79402745-79403244 Neighboring gene prostate cancer associated 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:79502679-79503275 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:79512967-79513466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19964 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:79571299-79571800 Neighboring gene LYPLA2 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79626622-79627122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79627123-79627623 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:79629105-79629618 Neighboring gene forkhead box B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene. Cardoso M, et al. Br J Cancer, 2023 Apr. PMID 36564567, Free PMC Article
    2. Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells. Islam MS, et al. BMC Cancer, 2019 Jun 6. PMID 31170959, Free PMC Article
    3. Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion. Yu W, et al. J Clin Endocrinol Metab, 2015 Feb. PMID 25387265
    4. Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues. Iwama E, et al. J Mol Neurosci, 2011 Jun. PMID 21234814
    5. FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis of Colorectal Cancer. Li T, et al. Technol Cancer Res Treat, 2022 Jan-Dec. PMID 35929169, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene.
      Title: Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene.
    2. FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis of Colorectal Cancer.
      Title: FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis of Colorectal Cancer.
    3. The programmed expression of full-length BMCC1 in human neuroblastoma cells undergoing DNA damage-induced apoptosis.
      Title: Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells.
    4. E2F1 directly facilitated BMCC1 transcription. These results also suggest that BMCC1 induced by E2F1 acts as a tumor suppressor through its pro-apoptotic function, resulted in favorable prognosis of neuroblastoma.
      Title: Transcriptional regulation of BMCC1 mediated by E2F1 in neuroblastoma cells.
    5. Results show prostate cancer antigen 3 (PCA3) as a dominant-negative oncogene and PRUNE2 protein as an unrecognized tumor suppressor gene in prostate cancer.
      Title: PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3.
    6. BMCC1 negatively regulates phosphorylation pathway of AKT, resulted in apoptosis and the BNIP2 homology region of BMCC1 interacts with BCL2.
      Title: BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis.
    7. recurrent germ line and somatic mutations in PRUNE2 were found in parathyroid carcinoma and computationally predicted to be deleterious; in addition, recurrent mutations in kinase genes related to cell migration and invasion were found.
      Title: Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion.
    8. BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells.
      Title: BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells.
    9. We showed that Olfaxin, a novel Prune2 isoform contains a BCH motif and localizes predominantly to the synaptic cytosol in the olfactory bulb and layer Ia of the piriform cortex.
      Title: Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system.
    10. PRUNE2 expression is correlated with the survival of leiomyosarcoma patients. Non-coding RNA PCA3 has a significant positive correlation with PRUNE2 and may play an important role in the pathogenesis of leiomyosarcoma.
      Title: [Expression of PRUNE2 mRNA and its positive correlation with non-coding RNA PCA3 in leiomyosarcoma].
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ50060, FLJ54876, FLJ59118, KIAA0367, A214N16.3, bA214N16.3, DKFZp762K117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    protein prune homolog 2
    Names
    BCH motif-containing molecule at the carboxyl terminal region 1
    BNIP2 motif containing molecule at the carboxyl terminal region 1
    BNIP2 motif-containing molecule at the C-terminal region 1
    olfaxin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308047.2 → NP_001294976.1  protein prune homolog 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains one alternate in-frame exon and lacks two consecutive in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB002365, AB535152, AL359314, AL390239, BC019095, BC022571, CB146736, FJ808772
      Consensus CDS
      CCDS78407.1
      UniProtKB/TrEMBL
      A0A088AWP5, G8XWS8
      Related
      ENSP00000393843.3, ENST00000443509.6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2908
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2920 → 3041
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    2. NM_001308048.2 → NP_001294977.1  protein prune homolog 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site, contains one alternate in-frame exon, and lacks two consecutive in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AB050197, AB535152, AL359314, AL390239, BC019095, BC022571
      UniProtKB/TrEMBL
      D6RTK6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2909
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2921 → 3042
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    3. NM_001308049.2 → NP_001294978.1  protein prune homolog 2 isoform 4

      See identical proteins and their annotated locations for NP_001294978.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks part of the 5' coding region, contains two alternate 5' exons, and uses an alternate start codon, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AB050197, AK296269, BC022571
      UniProtKB/TrEMBL
      B4DJW7, C9K0Q0
      Conserved Domains (2) summary
      pfam12496
      Location:48 → 164
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:166 → 287
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    4. NM_001308050.2 → NP_001294979.1  protein prune homolog 2 isoform 5

      See identical proteins and their annotated locations for NP_001294979.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks part of the 5' coding region, contains an alternate 5'-terminal exon, and uses an alternate start codon, compared to variant 1. The encoded isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AB050197, AK298805, BC022571
      UniProtKB/Swiss-Prot
      Q8WUY3
      Conserved Domains (2) summary
      pfam12496
      Location:63 → 179
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:181 → 302
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    5. NM_001308051.2 → NP_001294980.1  protein prune homolog 2 isoform 6

      See identical proteins and their annotated locations for NP_001294980.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks part of the 5' and 3' coding region, contains an alternate 5'-terminal exon, and uses an alternate start codon and an alternate in-frame splice site, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AB050197, AK299857, BC022571, DC342565
      UniProtKB/TrEMBL
      B4DSQ3, C9JCJ6
      Conserved Domains (2) summary
      pfam12496
      Location:63 → 180
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:182 → 303
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    6. NM_001330680.2 → NP_001317609.1  protein prune homolog 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL161626, AL359314
      Consensus CDS
      CCDS83375.1
      UniProtKB/TrEMBL
      Q5JUB8
      Related
      ENSP00000365907.2, ENST00000376717.6

    7. NM_015225.3 → NP_056040.2  protein prune homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_056040.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB050197, AL359314, AL390239, BC019095, BQ008420, DA410068
      Consensus CDS
      CCDS47982.1
      UniProtKB/Swiss-Prot
      B3KYC4, B4DQH8, O15073, Q58A63, Q5JUB6, Q5T304, Q5T476, Q6T2V6, Q6T2V7, Q8N665, Q8WUY3
      UniProtKB/TrEMBL
      G8XWS8
      Related
      ENSP00000365908.3, ENST00000376718.8
      Conserved Domains (3) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      cd00170
      Location:2899 → 3045
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam12496
      Location:2799 → 2915
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

    RNA

    1. NR_131751.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains one alternate exon and lacks several internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB002365, AB535152, AL359314, AL390239, BC019095, BC022571, FJ808772, FJ808773

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      76611376..76906114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422884.1 → XP_047278840.1  protein prune homolog 2 isoform X25

    2. XM_017014349.2 → XP_016869838.1  protein prune homolog 2 isoform X17

      UniProtKB/TrEMBL
      G8XWS8

    3. XM_017014352.2 → XP_016869841.1  protein prune homolog 2 isoform X21

      UniProtKB/TrEMBL
      G8XWS8

    4. XM_017014346.2 → XP_016869835.1  protein prune homolog 2 isoform X12

      UniProtKB/TrEMBL
      G8XWS8

    5. XM_006716986.2 → XP_006717049.1  protein prune homolog 2 isoform X5

      UniProtKB/TrEMBL
      G8XWS8
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2915
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2917 → 3038
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    6. XM_005251748.2 → XP_005251805.1  protein prune homolog 2 isoform X8

      UniProtKB/TrEMBL
      G8XWS8
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2908
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2920 → 3041
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    7. XM_006716983.2 → XP_006717046.1  protein prune homolog 2 isoform X2

      UniProtKB/TrEMBL
      G8XWS8
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2908
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2920 → 3041
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    8. XM_005251754.3 → XP_005251811.1  protein prune homolog 2 isoform X23

      UniProtKB/TrEMBL
      D6RTK6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2916
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2918 → 3039
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    9. XM_017014348.2 → XP_016869837.1  protein prune homolog 2 isoform X16

      UniProtKB/TrEMBL
      D6RTK6

    10. XM_011518323.3 → XP_011516625.1  protein prune homolog 2 isoform X9

      UniProtKB/TrEMBL
      D6RTK6
      Related
      ENSP00000397425.1, ENST00000428286.5
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2916
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2918 → 3039
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    11. XM_017014351.2 → XP_016869840.1  protein prune homolog 2 isoform X19

      UniProtKB/TrEMBL
      D6RTK6

    12. XM_005251750.2 → XP_005251807.1  protein prune homolog 2 isoform X10

      UniProtKB/TrEMBL
      D6RTK6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2916
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2918 → 3039
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    13. XM_006716985.2 → XP_006717048.1  protein prune homolog 2 isoform X3

      UniProtKB/TrEMBL
      D6RTK6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2916
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2918 → 3039
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    14. XM_047422883.1 → XP_047278839.1  protein prune homolog 2 isoform X24

    15. XM_011518327.2 → XP_011516629.1  protein prune homolog 2 isoform X14

      UniProtKB/TrEMBL
      D6RTK6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2909
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2921 → 3042
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    16. XM_005251745.2 → XP_005251802.1  protein prune homolog 2 isoform X6

      UniProtKB/TrEMBL
      D6RTK6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2909
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2921 → 3042
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    17. XM_005251751.2 → XP_005251808.1  protein prune homolog 2 isoform X18

      UniProtKB/TrEMBL
      D6RTK6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2909
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2921 → 3042
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    18. XM_011518328.3 → XP_011516630.1  protein prune homolog 2 isoform X20

      UniProtKB/TrEMBL
      D6RTK6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2909
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2921 → 3042
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    19. XM_005251746.2 → XP_005251803.1  protein prune homolog 2 isoform X7

      UniProtKB/TrEMBL
      D6RTK6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2909
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2921 → 3042
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    20. XM_011518326.3 → XP_011516628.1  protein prune homolog 2 isoform X13

      UniProtKB/TrEMBL
      D6RTK6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2909
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2921 → 3042
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    21. XM_006716982.2 → XP_006717045.1  protein prune homolog 2 isoform X1

      UniProtKB/TrEMBL
      D6RTK6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2909
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2921 → 3042
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    22. XM_006716984.3 → XP_006717047.1  protein prune homolog 2 isoform X4

      UniProtKB/TrEMBL
      D6RTK6
      Conserved Domains (4) summary
      COG1227
      Location:24 → 278
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:221 → 315
      DHHA2; DHHA2 domain
      pfam12496
      Location:2799 → 2909
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2921 → 3042
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    23. XM_047422885.1 → XP_047278841.1  protein prune homolog 2 isoform X26

    24. XM_017014357.3 → XP_016869846.1  protein prune homolog 2 isoform X29

    25. XM_017014359.3 → XP_016869848.1  protein prune homolog 2 isoform X30

    26. XM_017014356.3 → XP_016869845.1  protein prune homolog 2 isoform X28

    27. XM_017014354.3 → XP_016869843.1  protein prune homolog 2 isoform X27

    28. XM_047422882.1 → XP_047278838.1  protein prune homolog 2 isoform X24

    29. XM_047422881.1 → XP_047278837.1  protein prune homolog 2 isoform X20

    30. XM_047422878.1 → XP_047278834.1  protein prune homolog 2 isoform X11

    31. XM_047422879.1 → XP_047278835.1  protein prune homolog 2 isoform X13

    32. XM_047422876.1 → XP_047278832.1  protein prune homolog 2 isoform X4

    33. XM_047422880.1 → XP_047278836.1  protein prune homolog 2 isoform X15

    34. XM_017014353.3 → XP_016869842.1  protein prune homolog 2 isoform X22

      UniProtKB/TrEMBL
      D6RTK6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      88767783..89062562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362198.1 → XP_054218173.1  protein prune homolog 2 isoform X25

    2. XM_054362188.1 → XP_054218163.1  protein prune homolog 2 isoform X17

    3. XM_054362193.1 → XP_054218168.1  protein prune homolog 2 isoform X21

    4. XM_054362183.1 → XP_054218158.1  protein prune homolog 2 isoform X12

    5. XM_054362176.1 → XP_054218151.1  protein prune homolog 2 isoform X5

    6. XM_054362179.1 → XP_054218154.1  protein prune homolog 2 isoform X8

    7. XM_054362172.1 → XP_054218147.1  protein prune homolog 2 isoform X2

    8. XM_054362195.1 → XP_054218170.1  protein prune homolog 2 isoform X23

    9. XM_054362187.1 → XP_054218162.1  protein prune homolog 2 isoform X16

    10. XM_054362180.1 → XP_054218155.1  protein prune homolog 2 isoform X9

    11. XM_054362190.1 → XP_054218165.1  protein prune homolog 2 isoform X19

    12. XM_054362181.1 → XP_054218156.1  protein prune homolog 2 isoform X10

    13. XM_054362173.1 → XP_054218148.1  protein prune homolog 2 isoform X3

    14. XM_054362197.1 → XP_054218172.1  protein prune homolog 2 isoform X24

    15. XM_054362186.1 → XP_054218161.1  protein prune homolog 2 isoform X14

    16. XM_054362177.1 → XP_054218152.1  protein prune homolog 2 isoform X6

    17. XM_054362189.1 → XP_054218164.1  protein prune homolog 2 isoform X18

    18. XM_054362192.1 → XP_054218167.1  protein prune homolog 2 isoform X20

    19. XM_054362178.1 → XP_054218153.1  protein prune homolog 2 isoform X7

    20. XM_054362185.1 → XP_054218160.1  protein prune homolog 2 isoform X13

    21. XM_054362171.1 → XP_054218146.1  protein prune homolog 2 isoform X1

    22. XM_054362175.1 → XP_054218150.1  protein prune homolog 2 isoform X4

    23. XM_054362199.1 → XP_054218174.1  protein prune homolog 2 isoform X26

    24. XM_054362202.1 → XP_054218177.1  protein prune homolog 2 isoform X29

    25. XM_054362203.1 → XP_054218178.1  protein prune homolog 2 isoform X30

    26. XM_054362201.1 → XP_054218176.1  protein prune homolog 2 isoform X28

    27. XM_054362200.1 → XP_054218175.1  protein prune homolog 2 isoform X27

    28. XM_054362196.1 → XP_054218171.1  protein prune homolog 2 isoform X24

    29. XM_054362191.1 → XP_054218166.1  protein prune homolog 2 isoform X20

    30. XM_054362182.1 → XP_054218157.1  protein prune homolog 2 isoform X11

    31. XM_054362184.1 → XP_054218159.1  protein prune homolog 2 isoform X13

    32. XM_054362174.1 → XP_054218149.1  protein prune homolog 2 isoform X4

    33. XM_054362194.1 → XP_054218169.1  protein prune homolog 2 isoform X22

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138818.2: Suppressed sequence

      Description
      NM_138818.2: This RefSeq was permanently suppressed because the CDS was partial.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WUY3.3 GenPept UniProtKB/Swiss-Prot:Q8WUY3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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