Tcrd T cell receptor delta chain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tcrdprovided by MGI
Official Full Name: T cell receptor delta chainprovided by MGI
Primary source: MGI:MGI:98611
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tcrdelta
Summary: T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha variable and joining genes. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Ten variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2012]
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Genomic context

Location:: 14 C2; 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (54183530..54396655)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (53946073..54159198)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Host-derived mannose glycans trigger a pathogenic gammadelta T cell/IL-17a axis in autoimmunity.
Title: Host-derived mannose glycans trigger a pathogenic γδ T cell/IL-17a axis in autoimmunity.
Characteristics of gammadeltaTCR on myeloid cells from C57BL/6 mice with Plasmodium yoelii nigeriensis infection.
Title: Characteristics of γδTCR on myeloid cells from C57BL/6 mice with Plasmodium yoelii nigeriensis infection.
This study demonstrated that LPS exposure induced reductions in white matter tissue volume in WT and Tcralpha (-/-) mice, but not in the Tcrd (-/-) mice, suggested that gammadeltaT cells but not alphabetaT cells contribute to sepsis-induced white matter injury and subsequent motor function abnormalities in early life.
Title: γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice.
Increased TCRgammadelta signal strength profoundly prohibited the development of all IL-17A-secreting gammadelta T cells, regardless of Vgamma usage, but promoted the development of gammadelta progenitors along the IFNgamma pathway.
Title: Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells.
Findings indicate a role for memory gammadelta T cells in orchestrating protective immune responses against intestinal pathogens.
Title: IL-17A-producing resident memory γδ T cells orchestrate the innate immune response to secondary oral Listeria monocytogenes infection.
Data show that inducible T cell co-stimulator (ICOS) deficient mice have a significant increase in the population of IL-17-producing Vgamma2+ gammadelta T cells in the thymus, spleen, lymph nodes and skin and exhibit exacerbated sensitization responses to 2,4-dinitrofluorobenzene.
Title: Development of interleukin-17-producing Vγ2+ γδ T cells is reduced by ICOS signaling in the thymus.
the majority of gammadelta T cells in the non-pregnant uterus, pregnant uterus, decidua and placenta of mice express the transcription factor RORgammat and produce interleukin-17 (IL-17).
Title: The majority of murine γδ T cells at the maternal-fetal interface in pregnancy produce IL-17.
Data indicate that gamma delta (GD) T cells are essential components of the adaptive and innate immune system in the female reproductive tract.
Title: Bacterial Vaginosis Is Associated with Loss of Gamma Delta T Cells in the Female Reproductive Tract in Women in the Miami Women Interagency HIV Study (WIHS): A Cross Sectional Study.
This study revealed a generalized and transient increase of circulating gamma-delta T cell receptor, T cells in mice with small, aggressive intracranial GL261 gliomas and prior to the onset of neurologic symptoms.
Title: Dynamics of Circulating γδ T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma.
Data indicate the function of promyelocytic leukaemia zinc finger PLZF in the development of innate-like interleukin-17, TcR gamma-delta (IL-17+Vgamma6+ gammadelta) T cells.
Title: PLZF Controls the Development of Fetal-Derived IL-17+Vγ6+ γδ T Cells.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

D14Mit259 (e-PCR), detects polymorphism
- UniSTS:127370

Tcrd (e-PCR), detects polymorphism
- UniSTS:259254

Tcrd (e-PCR), detects polymorphism
- UniSTS:144581

PMC15475P1 (e-PCR)
- UniSTS:271316

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Names: T cell receptor delta chain; Tcr delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.