HKT1 high-affinity K+ transporter 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: HKT1
Gene description: high-affinity K+ transporter 1
Primary source: Araport:AT4G10310
Locus tag: AT4G10310
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATHKT1; high-affinity K+ transporter 1; HKT1;1; T9A4.5
Summary: encodes a sodium transporter (HKT1) expressed in xylem parenchyma cells. Mutants over-accumulate sodium in shoot tissue and have increased sodium in the xylem sap and reduced sodium in phloem sap and roots.
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Genomic context

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Location:: chromosome: 4

Exon count:: 3

Sequence:: Chromosome: 4; NC_003075.7 (6391854..6395922)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The HKT1 Na[+] transporter protects plant fertility by decreasing Na[+] content in stamen filaments.
Title: The HKT1 Na(+) transporter protects plant fertility by decreasing Na(+) content in stamen filaments.
The Arabidopsis phosphatase PP2C49 negatively regulates salt tolerance through inhibition of AtHKT1;1.
Title: The Arabidopsis phosphatase PP2C49 negatively regulates salt tolerance through inhibition of AtHKT1;1.
The constitutive overexpression of AtHKT1 reduces Na(+) accumulation in potato leaves and promotes the K(+)/Na(+) homeostasis that minimizes osmotic imbalance, maintains photosynthesis and stomatal conductance, and increases plant productivity.
Title: Improving salt tolerance in potato through overexpression of AtHKT1 gene.
HKT1;1 loss induced decrease and increase in transcripts of AtSKOR and AtHAK5, respectively.
Title: The Effect of AtHKT1;1 or AtSOS1 Mutation on the Expressions of Na⁺ or K⁺ Transporter Genes and Ion Homeostasis in Arabidopsis thaliana under Salt Stress.
The amino-acid substitutionof Asp, replacing Asn in HKT1 altered cation selectivity and uptake dynamics and lead to plant salt tolerance.
Title: A Single Amino-Acid Substitution in the Sodium Transporter HKT1 Associated with Plant Salt Tolerance.
broad range of metabolites and elements in shoots and roots of different AtHKT1;1 genotypes
Title: Characterization of ion contents and metabolic responses to salt stress of different Arabidopsis AtHKT1;1 genotypes and their parental strains.
ABI4 binds two highly related sites within the HKT1;1 promoter.ABI4 downregulates expression of the sodium transporter HKT1;1 in Arabidopsis roots.
Title: ABI4 downregulates expression of the sodium transporter HKT1;1 in Arabidopsis roots and affects salt tolerance.
AtHKT1;1 mediates nernstian sodium channel transport properties in Arabidopsis root stelar cells.
Title: AtHKT1;1 mediates nernstian sodium channel transport properties in Arabidopsis root stelar cells.
Cytokinin acts through ARR1 and ARR12 to regulate AtHKT1;1 expression.
Title: Type-B response regulators ARR1 and ARR12 regulate expression of AtHKT1;1 and accumulation of sodium in Arabidopsis shoots.
Cis-regulatory expression level polymorphisms at the AtHKT1;1 locus, encoding a known sodium (Na(+)) transporter, was identified as being a major factor controlling natural variation in leaf Na(+) accumulation capacity in the A. thaliana population.
Title: A coastal cline in sodium accumulation in Arabidopsis thaliana is driven by natural variation of the sodium transporter AtHKT1;1.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Homology

Orthologs from OrthoDB

NM_117099.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables potassium ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sodium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: high-affinity K+ transporter 1

NP_567354.1

high-affinity K+ transporter 1 (HKT1); CONTAINS InterPro DOMAIN/s: Potassium transport protein, high-affinity (InterPro:IPR004773), Cation transporter (InterPro:IPR003445); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

6391854..6395922

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117099.6 → NP_567354.1 high-affinity K+ transporter 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567354.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O82614, Q68KI5, Q84TI7, Q9M570, Q9SV90

UniProtKB/TrEMBL

A0A178UX71, A0A654FMV5, Q0WQW6

Conserved Domains (2) summary

TIGR00933
Location:55 → 487

2a38; potassium uptake protein, TrkH family

cl17365
Location:58 → 487

TrkH; Cation transport protein