LPCAT1 lysophosphatidylcholine acyltransferase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LPCAT1provided by HGNC
Official Full Name: lysophosphatidylcholine acyltransferase 1provided by HGNC
Primary source: HGNC:HGNC:25718
See related: Ensembl:ENSG00000153395 MIM:610472; AllianceGenome:HGNC:25718
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AYTL2; lpcat; AGPAT9; LPLAT8; PFAAP3; AGPAT10; LPCAT-1; lysoPAFAT
Summary: This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016]
Expression: Broad expression in lung (RPKM 73.0), spleen (RPKM 32.6) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5p15.33

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (1461427..1523960, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (1373271..1435654, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (1461542..1524075, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LPCAT1 promotes melanoma cell proliferation via Akt signaling.
Title: LPCAT1 promotes melanoma cell proliferation via Akt signaling.
Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis.
Title: Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis.
LncRNA AC012360.1 facilitates growth and metastasis by regulating the miR-139-5p/LPCAT1 axis in hepatocellular carcinoma.
Title: LncRNA AC012360.1 facilitates growth and metastasis by regulating the miR-139-5p/LPCAT1 axis in hepatocellular carcinoma.
Biomarkers of ulcerative colitis disease activity CXCL1, CYP2R1, LPCAT1, and NEU4 and their relationship to immune infiltrates.
Title: Biomarkers of ulcerative colitis disease activity CXCL1, CYP2R1, LPCAT1, and NEU4 and their relationship to immune infiltrates.
LPCAT1 enhances the invasion and migration in gastric cancer: Based on computational biology methods and in vitro experiments.
Title: LPCAT1 enhances the invasion and migration in gastric cancer: Based on computational biology methods and in vitro experiments.
The validation and clinical significance of LPCAT1 down-regulation in acute myeloid leukemia.
Title: The validation and clinical significance of LPCAT1 down-regulation in acute myeloid leukemia.
Knockdown of LPCAT1 Repressed Hepatocellular Carcinoma Growth and Invasion by Targeting S100A11.
Title: Knockdown of LPCAT1 Repressed Hepatocellular Carcinoma Growth and Invasion by Targeting S100A11.
Lysophosphatidylcholine acyltransferase 1 protein is present in maternal blood in the third trimester and is upregulated by antenatal corticosteroids.
Title: Lysophosphatidylcholine acyltransferase 1 protein is present in maternal blood in the third trimester and is upregulated by antenatal corticosteroids.
[Prognostic Significance of LPCAT1 in Adult Acute Myeloid Leukemia Patients with FAB Subtype M2].
Title: [Prognostic Significance of LPCAT1 in Adult Acute Myeloid Leukemia Patients with FAB Subtype M2].
sn-1 Specificity of Lysophosphatidylcholine Acyltransferase-1 Revealed by a Mass Spectrometry-Based Assay.
Title: sn-1 Specificity of Lysophosphatidylcholine Acyltransferase-1 Revealed by a Mass Spectrometry-Based Assay.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5S1652E (e-PCR)
- UniSTS:151046

SHGC-145778 (e-PCR)
- UniSTS:184087

D5S2269E (e-PCR)
- UniSTS:154475

A003B27 (e-PCR)
- UniSTS:59539

NIB2003 (e-PCR)
- UniSTS:1964

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	TAS Traceable Author Statement more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerophosphocholine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-alkenylglycerophosphocholine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-alkylglycerophosphocholine O-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-alkylglycerophosphocholine O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 2-acylglycerol-3-phosphate O-acyltransferase activity	TAS Traceable Author Statement more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables plasmalogen synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidic acid biosynthetic process	TAS Traceable Author Statement more info
involved_in phosphatidylcholine acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine acyl-chain remodeling	TAS Traceable Author Statement more info
involved_in phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylglycerol acyl-chain remodeling	TAS Traceable Author Statement more info
involved_in phospholipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in surfactant homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in azurophil granule membrane	TAS Traceable Author Statement more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: lysophosphatidylcholine acyltransferase 1

Names: 1-acylglycerol-3-phosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; LPC acyltransferase 1; acetyl-CoA:lyso-PAF acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase; acyltransferase-like 2; lyso-PAF acetyltransferase; lysoPC acyltransferase 1; lysophospholipid acyltransferase 8; phosphonoformate immuno-associated protein 3

NP_079106.3

EC 2.3.1.23

EC 2.3.1.25

EC 2.3.1.51

EC 2.3.1.67

XP_005248430.1

EC 2.3.1.23

EC 2.3.1.25

EC 2.3.1.51

EC 2.3.1.67

XP_011512434.2

EC 2.3.1.23

EC 2.3.1.25

EC 2.3.1.51

EC 2.3.1.67

XP_011512436.1

EC 2.3.1.23

EC 2.3.1.25

EC 2.3.1.51

EC 2.3.1.67

XP_047273719.1

EC 2.3.1.23

EC 2.3.1.25

EC 2.3.1.51

EC 2.3.1.67

XP_054209495.1

EC 2.3.1.23

EC 2.3.1.25

EC 2.3.1.51

EC 2.3.1.67

XP_054209496.1

EC 2.3.1.23

EC 2.3.1.25

EC 2.3.1.51

EC 2.3.1.67

XP_054209497.1

EC 2.3.1.23

EC 2.3.1.25

EC 2.3.1.51

EC 2.3.1.67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051622.1 RefSeqGene

Range

5018..67551

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_024830.5 → NP_079106.3 lysophosphatidylcholine acyltransferase 1

See identical proteins and their annotated locations for NP_079106.3

Status: REVIEWED

Source sequence(s)

AB244719, BC020166, BI770498, CA425992, CR982813

Consensus CDS

CCDS3864.1

UniProtKB/Swiss-Prot

Q1HAQ1, Q7Z4G6, Q8N3U7, Q8NF37, Q8WUL8, Q9GZW6

UniProtKB/TrEMBL

A0A0G2JQ62

Related

ENSP00000283415.3, ENST00000283415.4

Conserved Domains (4) summary

cd07991
Location:103 → 314

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

COG0204
Location:58 → 242

PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

pfam13499
Location:421 → 479

EF-hand_7; EF-hand domain pair

pfam13833
Location:432 → 483

EF-hand_8; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

1461427..1523960 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005248373.4 → XP_005248430.1 lysophosphatidylcholine acyltransferase 1 isoform X2

See identical proteins and their annotated locations for XP_005248430.1

UniProtKB/TrEMBL

A0A0G2JQ62

Conserved Domains (4) summary

cd07991
Location:55 → 266

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

COG0204
Location:10 → 194

PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

pfam13499
Location:373 → 431

EF-hand_7; EF-hand domain pair

pfam13833
Location:384 → 435

EF-hand_8; EF-hand domain pair
XM_047417763.1 → XP_047273719.1 lysophosphatidylcholine acyltransferase 1 isoform X2
XM_011514134.2 → XP_011512436.1 lysophosphatidylcholine acyltransferase 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JQ62

Conserved Domains (4) summary

cd07991
Location:62 → 273

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

COG0204
Location:17 → 201

PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

pfam13499
Location:380 → 438

EF-hand_7; EF-hand domain pair

pfam13833
Location:391 → 442

EF-hand_8; EF-hand domain pair
XM_011514132.2 → XP_011512434.2 lysophosphatidylcholine acyltransferase 1 isoform X3

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_187547.1 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

8167..48346

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

1373271..1435654 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054353522.1 → XP_054209497.1 lysophosphatidylcholine acyltransferase 1 isoform X2
XM_054353521.1 → XP_054209496.1 lysophosphatidylcholine acyltransferase 1 isoform X1
XM_054353520.1 → XP_054209495.1 lysophosphatidylcholine acyltransferase 1 isoform X4