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    PVgp1 capsid protein VP0;genome polyprotein;precursor polypeptide P1;precursor polypeptide P2;precursor polypeptide P3;precursor protein 3BCD;protein 2BC [ Enterovirus C ]

    Gene ID: 919920, updated on 22-Sep-2023

    Summary

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    Gene symbol
    PVgp1
    Gene description
    capsid protein VP0;genome polyprotein;precursor polypeptide P1;precursor polypeptide P2;precursor polypeptide P3;precursor protein 3BCD;protein 2BC
    Locus tag
    PVgp1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Enterovirus C (strain: Human poliovirus 1 Mahoney)
    Lineage
    Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Picornavirales; Picornaviridae; Enterovirus
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    Genomic context

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    Sequence:
    NC_002058.3 (743..7372)

    NC_002058.3Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002058.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel point mutation (L70P) inactivates poliovirus 3C protease. Uma M, et al. Acta Virol, 2018. PMID 29521105
    2. Poliovirus Polymerase Leu420 Facilitates RNA Recombination and Ribavirin Resistance. Kempf BJ, et al. J Virol, 2016 Oct 1. PMID 27412593, Free PMC Article
    3. Surface for catalysis by poliovirus RNA-dependent RNA polymerase. Wang J, et al. J Mol Biol, 2013 Jul 24. PMID 23583774, Free PMC Article
    4. Polyprotein context regulates the activity of poliovirus 2CATPase bound to bilayer nanodiscs. Springer CL, et al. J Virol, 2013 May. PMID 23514879, Free PMC Article
    5. Structural features of a picornavirus polymerase involved in the polyadenylation of viral RNA. Kempf BJ, et al. J Virol, 2013 May. PMID 23468507, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. L70P point mutation inactivates 3C protease because of its close proximity to the 3C catalytic site.
      Title: A novel point mutation (L70P) inactivates poliovirus 3C protease.
    2. The authors conclude that 3D(pol) Leu420 is critically important for RNA recombination and that RNA recombination contributes to ribavirin resistance.
      Title: Poliovirus Polymerase Leu420 Facilitates RNA Recombination and Ribavirin Resistance.
    3. The authors propose that cleavage of and subverting the function of hnRNPM by 3C protease is a general strategy utilized by picornaviruses to facilitate viral infection.
      Title: Heterogeneous Nuclear Ribonucleoprotein M Facilitates Enterovirus Infection.
    4. Macromolecular assemblies of poliovirus 3D polymerase show repeated use of flexible interface interactions for polymerase lattice formation, suggesting that adaptability of polymerase-polymerase interactions facilitates RNA replication.
      Title: Surface for catalysis by poliovirus RNA-dependent RNA polymerase.
    5. These data lead to a model wherein the replication complex can be assembled with a minimally active form of 2C that then becomes fully activated by proteolytic cleavage from the adjacent 2B viroporin domain.
      Title: Polyprotein context regulates the activity of poliovirus 2CATPase bound to bilayer nanodiscs.
    6. Reaction mixtures containing purified 3D(pol) and a template RNA with a defined poly(U) sequence provided data consistent with a template-dependent reiterative transcription mechanism for polyadenylation.
      Title: Structural features of a picornavirus polymerase involved in the polyadenylation of viral RNA.
    7. motif D of poliovirus RdRps and, by inference, reverse transcriptases is the functional equivalent to the fidelity helix of other polymerases.
      Title: Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition.
    8. study led to identification of new sites within the 2C(ATPase) polypeptide required for RNA replication, revealed a new domain near the C terminus of 2C(ATPase) that is involved in encapsidation and confirmed that interaction between 2C(ATPase) and capsid proteins is involved in viral morphogenesis
      Title: Alanine scanning of poliovirus 2CATPase reveals new genetic evidence that capsid protein/2CATPase interactions are essential for morphogenesis.
    9. The authors report the translocon-mediated insertion of the 2B product into the endoplasmic reticulum membrane as a double-spanning integral membrane protein with an N-/C-terminal cytoplasmic orientation.
      Title: Membrane integration of poliovirus 2B viroporin.
    10. These results indicate that, in 80S particles, a significant fraction of VP1 can deviate from icosahedral symmetry.
      Title: An externalized polypeptide partitions between two distinct sites on genome-released poliovirus particles.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    General gene information

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    conflict

    • Loc: 1467-1468
    • Loc: 1529-1530
    • Loc: 1534-1535
    • Loc: 1547
    • Loc: 1579
    • Loc: 1601
    • Loc: 1668
    • Loc: 2001
    • Loc: 2004-2006
    • Loc: 2035
    • Loc: 2133
    • Loc: 2286
    • Loc: 2983
    • Loc: 3043
    • Loc: 3303-3304
    • Loc: 3308
    • Loc: 3657
    • Loc: 3696
    • Loc: 3766
    • Loc: 4158
    • Loc: 4163-4164
    • Loc: 4174
    • Loc: 5113
    • Loc: 5598
    • Loc: 5619-5623
    • Loc: 5645
    • Loc: 5786
    • Loc: 5903-5905
    • Loc: 5927-5931
    • Loc: 5970-5971
    • Loc: 5997
    • Loc: 6019
    • Loc: 6021
    • Loc: 6261
    • Loc: 6845-6847
    • Loc: 6978-6979
    • Loc: 7258

    General protein information

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    Preferred Names
    capsid protein VP0;genome polyprotein;precursor polypeptide P1;precursor polypeptide P2;precursor polypeptide P3;precursor protein 3BCD;protein 2BC
    Names
    capsid protein VP4
    capsid protein VP2
    capsid protein VP3
    capsid protein VP1
    protease 2A
    protein 2B
    protein 2C
    protein 3A
    protein 3AB
    viral protein genome-linked
    protease 3C
    protein 3CD
    RNA-directed RNA polymerase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002058.3 Reference assembly

      Range
      743..7372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_041277.1 genome polyprotein [Enterovirus C]

      See identical proteins and their annotated locations for NP_041277.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A142KD04, P03299, P03300, Q84879, Q84880, Q89679
      UniProtKB/TrEMBL
      Q8QXN9
      Conserved Domains (8) summary
      pfam00548
      Location:1566 → 1731
      Peptidase_C3; 3C cysteine protease (picornain 3C)
      pfam01552
      Location:1030 → 1128
      Pico_P2B; Picornavirus 2B protein
      pfam02226
      Location:2 → 69
      Pico_P1A; Picornavirus coat protein (VP4)
      pfam00073
      Location:93 → 307
      Rhv; picornavirus capsid protein
      pfam00910
      Location:1252 → 1350
      RNA_helicase; RNA helicase
      pfam00947
      Location:899 → 1025
      Pico_P2A; Picornavirus core protein 2A
      pfam08727
      Location:1453 → 1515
      P3A; Poliovirus 3A protein like
      cl02808
      Location:1765 → 2207
      RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...

    2. NP_740468.1 capsid protein VP4

      UniProtKB/TrEMBL
      Q4LG79, Q4LG80, Q84868
      Conserved Domains (1) summary
      pfam02226
      Location:1 → 68
      Pico_P1A; Picornavirus coat protein (VP4)

    3. NP_740469.1 capsid protein VP2

      Conserved Domains (1) summary
      pfam00073
      Location:24 → 239
      Rhv; picornavirus capsid protein

    4. NP_740470.1 capsid protein VP3

      UniProtKB/TrEMBL
      Q84870
      Conserved Domains (1) summary
      pfam00073
      Location:28 → 194
      Rhv; picornavirus capsid protein

    5. NP_740471.1 capsid protein VP1

      UniProtKB/TrEMBL
      B7U659, Q8QNT2
      Conserved Domains (1) summary
      pfam00073
      Location:57 → 211
      Rhv; picornavirus capsid protein

    6. NP_740477.1 protease 2A

      UniProtKB/TrEMBL
      T1WTS3
      Conserved Domains (1) summary
      pfam00947
      Location:18 → 144
      Pico_P2A; Picornavirus core protein 2A

    7. NP_740472.1 protein 2B

      UniProtKB/TrEMBL
      Q9IHF2
      Conserved Domains (1) summary
      pfam01552
      Location:1 → 97
      Pico_P2B; Picornavirus 2B protein

    8. NP_740473.1 protein 2C

      UniProtKB/TrEMBL
      Q84874
      Conserved Domains (1) summary
      pfam00910
      Location:125 → 223
      RNA_helicase; RNA helicase

    9. NP_740474.1 protein 3A

      Conserved Domains (1) summary
      pfam08727
      Location:1 → 59
      P3A; Poliovirus 3A protein like

    10. YP_007353733.1 protein 3AB

      Conserved Domains (1) summary
      pfam08727
      Location:1 → 59
      P3A; Poliovirus 3A protein like

    11. NP_740475.1 viral protein genome-linked

      UniProtKB/TrEMBL
      Q4VFT1, Q4VFT4, Q4VFT7, Q76R70

    12. NP_740476.2 protease 3C

      UniProtKB/TrEMBL
      Q66304, Q66305, Q66307
      Conserved Domains (1) summary
      pfam00548
      Location:1 → 166
      Peptidase_C3; 3C cysteine protease (picornain 3C)

    13. YP_007353734.1 protein 3CD

      Conserved Domains (2) summary
      pfam00548
      Location:1 → 166
      Peptidase_C3; 3C cysteine protease (picornain 3C)
      cl02808
      Location:200 → 642
      RT_like; RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, ...

    14. NP_740478.2 RNA-directed RNA polymerase

      UniProtKB/TrEMBL
      K4GXB6, K4GXN3
      Conserved Domains (1) summary
      cd01699
      Location:139 → 404
      RNA_dep_RNAP; RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage. RdRp catalyzes synthesis of the RNA strand complementary to a given RNA template. RdRps of many viruses are products of ...
    Protein Accession Links
    GenPept Link UniProtKB Link
    CAA24461.1

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