CESA6 cellulose synthase 6 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: CESA6
Gene description: cellulose synthase 6
Primary source: Araport:AT5G64740
Locus tag: AT5G64740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: cellulose synthase 6; E112; ISOXABEN RESISTANT 2; IXR2; MVP7.7; MVP7_7; PRC1; PROCUSTE 1
Summary: Encodes a cellulose synthase isomer. CESA6 mutants have cellulose defect in the primary cell wall. Multiple lines of evidence suggest that CESA6, along with CESA1 and CESA3 are present in the same plasma membrane complex for cellulose biosynthesis. CESA2 and CESA5 are related to CESA6, having partially redundant roles. As inferred from the null role of secondary wall-type CesAs, included in a set of five primary wall-type CesAs that may support trichome cell wall thickening.
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Genomic context

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See CESA6 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 13

Sequence:: Chromosome: 5; NC_003076.8 (25881033..25886728)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The N-terminal zinc finger of CELLULOSE SYNTHASE6 is critical in defining its functional properties by determining the level of homodimerization in Arabidopsis.
Title: The N-terminal zinc finger of CELLULOSE SYNTHASE6 is critical in defining its functional properties by determining the level of homodimerization in Arabidopsis.
A mutation in the catalytic domain of cellulose synthase 6 halts its transport to the Golgi apparatus.
Title: A mutation in the catalytic domain of cellulose synthase 6 halts its transport to the Golgi apparatus.
AtCesA6-null mutants showed a reduced cell elongation of young seedlings with little impact on cell division, which consequently affected cell wall integrity and biomass yield of mature plants.
Title: Cellulose Synthase Mutants Distinctively Affect Cell Growth and Cell Wall Integrity for Plant Biomass Production in Arabidopsis.
the sustained cellulose synthesis is important for salt stress tolerance in Arabidopsis.
Title: Cellulose synthesis genes CESA6 and CSI1 are important for salt stress tolerance in Arabidopsis.
Data indicates that the CC proteins have a broad role in aiding cellulose synthesis during environmental changes and when core complex components are non-functional. [CeSa6]
Title: The cellulose synthase companion proteins act non-redundantly with CELLULOSE SYNTHASE INTERACTING1/POM2 and CELLULOSE SYNTHASE 6.
The stoichiometry of the cellulose synthase catalytic subunits (CESAs) in the primary cell wall CSC was determined and CESA1, CESA3, and CESA6 are present in a 1:1:1 molecular ratio.
Title: Catalytic subunit stoichiometry within the cellulose synthase complex.
computational findings on transmembrane helices (TMHs) 5 and 6 in three CESAs of Arabidopsis thaliana (AtCESA1, 3, and 6), the Atcesa3(ixr1-2) mutant, and a novel missense mutation in AtCESA1, are reported.
Title: Computational and genetic evidence that different structural conformations of a non-catalytic region affect the function of plant cellulose synthase.
together with eto1, cesa6(ret8) and det2(ret41) exhibited an enhanced phenotype in the hypocotyls and apical hooks of etiolated seedlings.
Title: A chemical genetics approach reveals a role of brassinolide and cellulose synthase in hypocotyl elongation of etiolated Arabidopsis seedlings.
PROCUSTE1 has a role in microtubule cortical array organization.
Title: Genetic evidence that cellulose synthase activity influences microtubule cortical array organization.
CESA 1, 3, and 6 form a complex which is important for cellulose synthesis.
Title: Features of the primary wall CESA complex in wild type and cellulose-deficient mutants of Arabidopsis thaliana.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_125870.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables cellulose synthase (UDP-forming) activity	IEA Inferred from Electronic Annotation more info
enables cellulose synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellulose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cortical microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type cell wall biogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within plant-type primary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
part_of cellulose synthase complex	NAS Non-traceable Author Statement more info	PubMed
colocalizes_with cortical microtubule, transverse to long axis	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cellulose synthase 6

NP_201279.1

cellulose synthase 6 (CESA6); FUNCTIONS IN: cellulose synthase activity, transferase activity, transferring glycosyl groups; INVOLVED IN: in 6 processes; LOCATED IN: cortical microtubule, transverse to long axis, Golgi apparatus, cellulose synthase complex, plasma membrane, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Cellulose synthase (InterPro:IPR005150), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: cellulose synthase 5 (TAIR:AT5G09870.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).