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    AT5G45060 Disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834537, updated on 15-Feb-2024

    Summary

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    Gene symbol
    AT5G45060
    Gene description
    Disease resistance protein (TIR-NBS-LRR class) family
    Primary source
    Araport:AT5G45060
    Locus tag
    AT5G45060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    K17O22.2; K17O22_2
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (18182038..18187081)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Trypsin family protein Neighboring gene Cytochrome c Neighboring gene Disease resistance protein (TIR-NBS-LRR class) Neighboring gene phloem protein 2-A8 Neighboring gene phloem protein 2-A6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RPS4-mediated disease resistance requires the combined presence of RPS4 transcripts with full-length and truncated open reading frames. Zhang XC, et al. Plant Cell, 2003 Oct. PMID 14523247, Free PMC Article
    2. Two linked pairs of Arabidopsis TNL resistance genes independently confer recognition of bacterial effector AvrRps4. Saucet SB, et al. Nat Commun, 2015 Mar 6. PMID 25744164
    3. Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Tamura K, et al. Plant Cell, 2010 Dec. PMID 21189294, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An R gene pair that resembles and is linked to RRS1/RPS4, designated as RRS1B/RPS4B, confers recognition of AvrRps4 from Pseudomonas syringae. [RPS4B]
      Title: Two linked pairs of Arabidopsis TNL resistance genes independently confer recognition of bacterial effector AvrRps4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_123874.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response-activating signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Disease resistance protein (TIR-NBS-LRR class) family
    NP_199319.1
    • Disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, nucleoside-triphosphatase activity, nucleotide binding, ATP binding; INVOLVED IN: signal transduction, apoptosis, defense response, innate immune response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT5G45250.1); Has 23011 Blast hits to 16697 proteins in 710 species: Archae - 20; Bacteria - 1528; Metazoa - 2742; Fungi - 144; Plants - 17776; Viruses - 0; Other Eukaryotes - 801 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18182038..18187081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344584.1 → NP_001330960.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FHF0
      UniProtKB/TrEMBL
      A0A5S9YB59, A0A654G909
      Conserved Domains (2) summary
      sd00033
      Location:662 → 684
      LRR_RI; leucine-rich repeat [structural motif]
      cl27891
      Location:2 → 1082
      LRR_3; Leucine Rich Repeat

    2. NM_123874.3 → NP_199319.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199319.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FHF0
      UniProtKB/TrEMBL
      A0A5S9YB59, A0A654G909
      Conserved Domains (2) summary
      sd00033
      Location:662 → 684
      LRR_RI; leucine-rich repeat [structural motif]
      cl27891
      Location:2 → 1082
      LRR_3; Leucine Rich Repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FHF0.1

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