FUS3 AP2/B3-like transcriptional factor family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: FUS3
Gene description: AP2/B3-like transcriptional factor family protein
Primary source: Araport:AT3G26790
Locus tag: AT3G26790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: FUSCA 3
Summary: Transcriptional factor with high similarity to the B3 region of the VP1/ABI3-like proteins. Full length FUS3 protein binds to the highly conserved RY motif [DNA motif CATGCA(TG)], present in many seed-specific promoters, and the B3 domains of this transcription factor is necessary for the specific interaction with the RY element. Transcriptional activity of FUS3 requires the B3 DNA-binding domain and an activation domain. FUS3 specifies cotyledon identity. Regulator of gene expression during late embryogenesis. Involved in the control foliar organ identity in Arabidopsis by regulating the synthesis of two hormones, abscisic acid and gibberellin. FUS3 together with LEC1 positively regulate the abundance of the ABI3 protein in the seed.
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Genomic context

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Location:: chromosome: 3

Exon count:: 6

Sequence:: Chromosome: 3; NC_003074.8 (9853828..9856212, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AIP2 targets FUS3 for degradation and plays a role in cotyledon development and flowering time in Arabidopsis.
Title: The E3 ligase ABI3-INTERACTING PROTEIN2 negatively regulates FUSCA3 and plays a role in cotyledon development in Arabidopsis thaliana.
FUS3 phosphorylation and SnRK1 are required for embryogenesis and integration of environmental cues to ensure the survival of the progeny.
Title: SnRK1 phosphorylation of FUSCA3 positively regulates embryogenesis, seed yield, and plant growth at high temperature in Arabidopsis.
LEAFY COTYLEDON2 (LEC2) was identified as an interacting factor of FUS3, and demonstrated that these two homologous B3 transcription factors interact to bind to the auxin biosynthesis gene YUCCA4 (YUC4) and synergistically activate its transcription during lateral roots formation.
Title: FUSCA3 interacting with LEAFY COTYLEDON2 controls lateral root formation through regulating YUCCA4 gene expression in Arabidopsis thaliana.
LEC1, LEC2 , and FUSCA3 transcripts are candidate targets of VAL1, acting through epigenetic and/or transcriptional repression.
Title: Potential targets of VIVIPAROUS1/ABI3-LIKE1 (VAL1) repression in developing Arabidopsis thaliana embryos.
This study examined the role of ABSCISIC ACID INSENSITIVE3 (ABI3), FUSCA3 (FUS3) and LEAFY COTYLEDON2 (LEC2), in the production of seed reserves in Arabidopsis.
Title: Complementation of Seed Maturation Phenotypes by Ectopic Expression of ABSCISIC ACID INSENSITIVE3, FUSCA3 and LEAFY COTYLEDON2 in Arabidopsis.
TT2 is directly bound to the regulatory region of FUSCA3, and mediates the expression of numerous genes in the fatty acid biosynthesis pathway.
Title: TRANSPARENT TESTA2 regulates embryonic fatty acid biosynthesis by targeting FUSCA3 during the early developmental stage of Arabidopsis seeds.
Examination of direct targets of FUS3 reveals that FUS3 acts primarily or exclusively as a transcriptional activator.
Title: Identification of direct targets of FUSCA3, a key regulator of Arabidopsis seed development.
FUS3 and AKIN10 functionally overlap in abscissic acid signaling, but play different roles in sugar responses during germination.
Title: Overlapping and distinct roles of AKIN10 and FUSCA3 in ABA and sugar signaling during seed germination.
Activation of FUS3 after germination dampens the expression of genes involved in the biosynthesis and response to the plant hormone ethylene, whereas a loss-of-function fus3 mutant shows many phenotypes consistent with increased ethylene signaling.
Title: The embryonic leaf identity gene FUSCA3 regulates vegetative phase transitions by negatively modulating ethylene-regulated gene expression in Arabidopsis.
FUS3 is phosphorylated by AKIN10. AKIN10 overexpression delays FUS3 degradation. AKIN10 and FUS3 function interactively to promote seed maturation, dormancy and inhibit developmental phase transitions.
Title: AKIN10 and FUSCA3 interact to control lateral organ development and phase transitions in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_113591.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within negative regulation of gibberellin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gibberellin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plant organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of abscisic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auxin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within somatic embryogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vegetative to reproductive phase transition of meristem	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: AP2/B3-like transcriptional factor family protein

NP_566799.1

FUSCA 3 (FUS3); CONTAINS InterPro DOMAIN/s: Transcriptional factor B3 (InterPro:IPR003340); BEST Arabidopsis thaliana protein match is: AP2/B3-like transcriptional factor family protein (TAIR:AT3G24650.1); Has 875 Blast hits to 861 proteins in 60 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 7; Plants - 523; Viruses - 0; Other Eukaryotes - 344 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

9853828..9856212 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113591.4 → NP_566799.1 AP2/B3-like transcriptional factor family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566799.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O82411, Q700C8, Q9LW31, Q9SAT8

UniProtKB/TrEMBL

A0A654FCX5

Conserved Domains (1) summary

cd10017
Location:90 → 192

B3_DNA; Plant-specific B3-DNA binding domain