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    APX2 ascorbate peroxidase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820121, updated on 15-Oct-2023

    Summary

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    Gene symbol
    APX2
    Gene description
    ascorbate peroxidase 2
    Primary source
    Araport:AT3G09640
    Locus tag
    AT3G09640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    APX1B; ASCORBATE PEROXIDASE 1B; ascorbate peroxidase 2; CS2
    Summary
    Encodes a cytosolic ascorbate peroxidase APX2. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (2956156..2958330)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Ribosomal protein L4/L1 family Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene minichromosome maintenance 8 Neighboring gene Tudor/PWWP/MBT superfamily protein Neighboring gene Ribosomal protein S12/S23 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhanced seed production under prolonged heat stress conditions in Arabidopsis thaliana plants deficient in cytosolic ascorbate peroxidase 2. Suzuki N, et al. J Exp Bot, 2013 Jan. PMID 23183257, Free PMC Article
    2. A mutation affecting ASCORBATE PEROXIDASE 2 gene expression reveals a link between responses to high light and drought tolerance. Rossel JB, et al. Plant Cell Environ, 2006 Feb. PMID 17080642
    3. Influence of salicylic acid on H2O2 production, oxidative stress, and H2O2-metabolizing enzymes. Salicylic acid-mediated oxidative damage requires H2O2. Rao MV, et al. Plant Physiol, 1997 Sep. PMID 9306697, Free PMC Article
    4. Photosynthetic electron transport regulates the expression of cytosolic ascorbate peroxidase genes in Arabidopsis during excess light stress. Karpinski S, et al. Plant Cell, 1997 Apr. PMID 9144965, Free PMC Article
    5. Proteome analysis of peroxisomes from dark-treated senescent Arabidopsis leaves. Pan R, et al. J Integr Plant Biol, 2018 Nov. PMID 29877633

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deficiency in APX2 resulted in a decreased tolerance to light stress, as well as an enhanced tolerance to salinity and oxidative stresses.
      Title: Enhanced seed production under prolonged heat stress conditions in Arabidopsis thaliana plants deficient in cytosolic ascorbate peroxidase 2.
    2. The drought tolerant alx8 mutant provides evidence for common steps in drought and high light stress response pathways.
      Title: A mutation affecting ASCORBATE PEROXIDASE 2 gene expression reveals a link between responses to high light and drought tolerance.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001035587.3
    NM_111798.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-ascorbate peroxidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ascorbate peroxidase 2
    NP_001030664.1
    • ascorbate peroxidase 2 (APX2); CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Peroxidases heam-ligand binding site (InterPro:IPR019793), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016), Peroxidase, active site (InterPro:IPR019794); BEST Arabidopsis thaliana protein match is: ascorbate peroxidase 1 (TAIR:AT1G07890.8); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_187575.2
    • ascorbate peroxidase 2 (APX2); CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Peroxidases heam-ligand binding site (InterPro:IPR019793), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016), Peroxidase, active site (InterPro:IPR019794); BEST Arabidopsis thaliana protein match is: ascorbate peroxidase 1 (TAIR:AT1G07890.8); Has 8439 Blast hits to 8256 proteins in 1276 species: Archae - 55; Bacteria - 2395; Metazoa - 20; Fungi - 832; Plants - 3373; Viruses - 0; Other Eukaryotes - 1764 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2956156..2958330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111798.4 → NP_187575.2  ascorbate peroxidase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187575.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1PER6, Q39006, Q67XB1, Q9SF39
      UniProtKB/TrEMBL
      A0A178VH43, A0A5S9XBP2, A0MEV1
      Conserved Domains (1) summary
      cl00196
      Location:1 → 251
      plant_peroxidase_like; Heme-dependent peroxidases similar to plant peroxidases

    2. NM_001035587.3 → NP_001030664.1  ascorbate peroxidase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030664.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1PER6, Q39006, Q67XB1, Q9SF39
      UniProtKB/TrEMBL
      A0A178VH43, A0A5S9XBP2, A0MEV1
      Conserved Domains (1) summary
      cl00196
      Location:1 → 251
      plant_peroxidase_like; Heme-dependent peroxidases similar to plant peroxidases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1PER6.3

    Gene LinkOut

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