Sdc2 syndecan 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sdc2provided by MGI
Official Full Name: syndecan 2provided by MGI
Primary source: MGI:MGI:1349165
See related: Ensembl:ENSMUSG00000022261 AllianceGenome:MGI:1349165
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hspg1; Synd2; syndecan-2; 4833414L08Rik
Summary: Predicted to enable PDZ domain binding activity and identical protein binding activity. Involved in regulation of dendrite morphogenesis. Predicted to be located in neuronal cell body and synapse. Predicted to be active in cell surface. Is expressed in several structures, including cranium; embryo mesenchyme; genitourinary system; jaw; and retina. Human ortholog(s) of this gene implicated in cleft lip and cleft palate. Orthologous to human SDC2 (syndecan 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 23.4), limb E14.5 (RPKM 19.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 13.74 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (32920869..33034867)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (32920723..33034721)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Shed syndecan-2 enhances colon cancer progression by increasing cooperative angiogenesis in the tumor microenvironment.
Title: Shed syndecan-2 enhances colon cancer progression by increasing cooperative angiogenesis in the tumor microenvironment.
Syndecan-2 enriches for hematopoietic stem cells and regulates stem cell repopulating capacity.
Title: Syndecan-2 enriches for hematopoietic stem cells and regulates stem cell repopulating capacity.
Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts.
Title: Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts.
Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation.
Title: Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation.
Syndecan Transmembrane Domain Specifically Regulates Downstream Signaling Events of the Transmembrane Receptor Cytoplasmic Domain.
Title: Syndecan Transmembrane Domain Specifically Regulates Downstream Signaling Events of the Transmembrane Receptor Cytoplasmic Domain.
The Effects of Syndecan on Osteoblastic Cell Adhesion Onto Nano-Zirconia Surface.
Title: The Effects of Syndecan on Osteoblastic Cell Adhesion Onto Nano-Zirconia Surface.
We used a transgenic mouse model with high syndecan-2 expression in osteoblasts to enrich the bone surface with cellular glycosaminoglycans ..syndecan-2 overexpression increased apoptosis of mesenchymal precursors within the bone marrow
Title: Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells.
Syndecan-2 expression is upregulated in colonic epithelia of mice with DSS-induced colitis via FOXO3 activation.
Title: Inflammatory hypoxia induces syndecan-2 expression through IL-1β-mediated FOXO3a activation in colonic epithelia.
In mouse melanoma cells, siRNA-mediated knockdown of syndecan-2 was associated with reduced melanin synthesis, whereas overexpression of syndecan-2 increased melanin synthesis.
Title: Syndecan-2 regulates melanin synthesis via protein kinase C βII-mediated tyrosinase activation.
The N-terminal growth-factor-like domain of amyloid-beta precursor protein is necessary for protein-receptor binding, whereas the E2-domain mediates interaction with membrane-anchored syndecan 2 and glypican 1.
Title: Soluble amyloid-β precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129475 (e-PCR)
- UniSTS:212781

D15Mit204 (e-PCR), detects polymorphism
- UniSTS:127572

Sdc2 (e-PCR), detects polymorphism
- UniSTS:466045

Sdc2 (e-PCR), detects polymorphism
- UniSTS:515983

RH136961 (e-PCR)
- UniSTS:219050

AA960457 (e-PCR)
- UniSTS:160442

U00674 (e-PCR)
- UniSTS:125636

D15Mit7 (e-PCR), detects polymorphism
- UniSTS:127691

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: syndecan-2

Names: HSPG; fibroglycan; heparan sulfate proteoglycan 1, cell surface-associated (fibroglycan); heparan sulfate proteoglycan core protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.