GEO DataSet Links for PMC (Select 2836667) - GEO DataSets

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Items: 2

Select item 2000196321.

Stromal gene expression in human esophageal cancer

(Submitter supplied) The incidence of esophageal and junctional adenocarcinoma has increased 6 fold in the last 30 years and 5 year survival remains less than 14%. Once considered an inert scaffold, the stromal compartment is now recognized to play a central role in invasive cancer. However, whether the stroma plays a role in the transition from pre-invasive to invasive disease is unknown. In this study we hypothesized that the altered expression of stromal genes influences the progression from pre-invasive to invasive disease. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4372
44 Samples

Download data: TXT

Series

Accession:: GSE19632

ID:: 200019632

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000195292.

Expression data from fibroblasts cultured from oesophageal biopsies, taken from metaplasia, dysplasia and EAC specimens.

(Submitter supplied) Since fibroblasts are a key component of the stroma with an established role in cancer, we investigated the contribution of fibroblasts to the signature observed in the stromal compartment. 13 clonally derived primary stromal fibroblasts were generated from metaplasia, dysplasia and EAC specimens. Expression of a panel of known fibroblast markers and concomitant absence of epithelial markers confirmed their fibroblastic origin. more...