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Domestication and growth hormone transgenesis cause similar changes in gene expression profiles in coho salmon

(Submitter supplied) By directly comparing gene expression in wild type, domestic, and GH transgenic strains of salmon, we have found that domestication and GH transgenesis are modifying similar genetic pathways. Genes in many different physiological pathways show modified expression in domestic and GH transgenic strains relative to wild-type, but effects are strongly correlated. Genes specifically involved in growth regulation (IGF-I, GHR, IGF-II, THR) are also concordantly regulated in domestic and transgenic fish, and both strains show elevated levels of circulating IGF-I. more...
Organism:
Osmerus mordax; Salmo salar; Coregonus clupeaformis; Oncorhynchus kisutch; Oncorhynchus mykiss; Oncorhynchus tshawytscha
Type:
Expression profiling by array
Platform:
GPL2716
29 Samples
Download data: TXT
Series
Accession:
GSE13846
ID:
200013846

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