GEO DataSet Links for PMC (Select 2647550) - GEO DataSets

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Items: 2

Select item 2000120561.

Expression Profile of CREB knockdown in Myeloid Leukemia Cells

(Submitter supplied) Background. The cAMP Response Element Binding Protein, CREB, is a transcription factor that regulates cell proliferation, differentiation, and survival in several model systems, including neuronal and hematopoietic cells. We demonstrated that CREB is overexpressed in acute myeloid and leukemia cells compared to normal hematopoietic stem cells. CREB knockdown inhibits leukemic cell proliferation in vitro and in vivo, but does not affect long-term hematopoietic reconstitution. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3487
Platform:: GPL570
20 Samples

Download data: CEL

Series

Accession:: GSE12056

ID:: 200012056

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 34872.

Transcription factor CREB depletion effect on myeloid leukemic cell line

Analysis of myeloid leukemia K562 cells depleted for cAMP Response Element Binding Protein (CREB), a transcription factor. CREB is overexpressed in bone marrow samples of patients with acute leukemia. Results provides insight into the molecular mechanisms by which CREB contributes to acute leukemia.