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Displacement and re-accumulation of centromeric cohesin during transient pre-anaphase centromere splitting

(Submitter supplied) The ring-shaped cohesin complex links sister chromatids until their timely segregation during mitosis. Cohesin is enriched at centromeres, where it provides the cohesive counter-force to bi-polar tension produced by the mitotic spindle. As a consequence of spindle tension, centromeric sequences transiently split in pre-anaphase cells, in some organisms up to several micrometeres. This ‘centromere breathing’ presents a paradox, how sister sequences separate where cohesin is most enriched. more...
Organism:
Saccharomyces cerevisiae
Type:
Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL347 GPL3723
15 Samples
Download data: CEL
Series
Accession:
GSE8661
ID:
200008661

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