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all[filt](1974)
Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.
The role of the N-terminal caspase cleavage site in the nucleoprotein of influenza A virus...The role of the N-terminal caspase cleavage site in the nucleoprotein of influenza A virus in vitro and in vivo.
Homo sapiens chromosome 21, GRCh37 primary reference assembly Homo sapiens chromosome 21, GRCh37 primary reference assembly
A novel homoplasmic mutation in mtDNA with a single evolutionary origin as a risk factor f...A novel homoplasmic mutation in mtDNA with a single evolutionary origin as a risk factor for cardiomyopathy.

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1:	AID: 2182	Summary \| Data (All)
	Modulation of the Metabotropic Glutamate Receptor mGluR4: Selectivity at mGluR7 [Confirmatory] Source: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Protein Target: metabotropic glutamate receptor [Rattus norvegicus] [gi: 458729] Compounds Active: 0; Tested: 1 Description: Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms... more

2:	AID: 2181	Summary \| Data (All)
	Modulation of the Metabotropic Glutamate Receptor mGluR4: Selectivity at mGluR8 [Confirmatory] Source: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Protein Target: glutamate receptor, metabotropic 8 precursor [Rattus norvegicus] [gi: 11559972] Compounds Active: 0; Tested: 1 Description: Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms... more

3:	AID: 2180	Summary \| Data (Active)
	Modulation of Metabotropic Glutmate Receptor mGluR4: Human PAM Fold-Shift [Confirmatory] Source: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Protein Target: Glutamate receptor, metabotropic 4 [Homo sapiens] [gi: 120660252] Compounds Active: 7; Tested: 9 Description: Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms... more

4:	AID: 2179	Summary \| Data (Active)
	Modulation of Metabotropic Glutamate Receptor mGluR4: Rat PAM Fold-Shift [Confirmatory] Source: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Protein Target: glutamate receptor, metabotropic 4 precursor [Rattus norvegicus] [gi: 12083595] Compounds Active: 7; Tested: 9 Description: Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms... more

5:	AID: 2178	Summary \| Data (Active)
	QFRET-based counterscreen for inhibitors of PFM18AAP: biochemical high throughput confirmation assay for inhibitors of the Cathepsin L proteinase (CTSL1). [Primary Screening] Source: The Scripps Research Institute Molecular Screening Center Protein Target: cathepsin L1 [Homo sapiens] [gi: 55958172] Compounds Active: 7; Tested: 2378 Description: Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provider:... more

6:	AID: 2091	Summary \| Data (Active)	Related BioAssays, Chemicals, Target, Literature, Other Links
	uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [Confirmatory] Source: Burnham Center for Chemical Genomics Protein Targets: Mint1 [Rattus norvegicus] [gi: 2625023]; calcium channel, voltage-dependent, N type, alpha 1B subunit [Homo sapiens] [gi: 4502523] Compounds Active: 133; Tested: 367 Description: Data Source: Burnham Center for Chemical Genomics (BCCG) Source Affiliation: Burnham Institute for Medical Research (BIMR, San Diego, CA) Network: NIH... more

7:	AID: 1904	Summary \| Data (Active)	Chemicals, Target, Literature
	siRNA Circadian Assay Source: The Genomics Institute of the Novartis Research Foundation (GNF) Substances Active: 527; Tested: 33364 Description: Description: To identify additional clock genes and modifiers, we conducted a genome-wide screen of ~90,000 siRNAs (QIAGEN Inc) in a human cellular model... more

8:	AID: 1826	Summary	Related BioAssays, Target, Literature, Other Links
	Summary small molecule antagonists of the binding of Siah-1 and a peptide ligand via a fluorescence polarization assay. [Summary] Source: Burnham Center for Chemical Genomics Protein Target: plectin 1 [Homo sapiens] [gi: 40849930] Substances Active: 0; Tested: 0 Description: Name: uHTS identification of small molecule antagonists of the binding of Siah-1 and a peptide ligand via a fluorescence polarization assay. Data Source:... more

9:	AID: 2177	Summary \| Data (Active)	Related BioAssays, Chemicals, Target, Other Links
	Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 2 (LYPLA2). [Primary Screening] Source: The Scripps Research Institute Molecular Screening Center Protein Target: lysophospholipase II [Homo sapiens] [gi: 4581413] Compounds Active: 1197; Tested: 315005 Description: Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provider:... more

10:	AID: 2176	Summary \| Data (Active)	Related BioAssays, Chemicals, Target, Literature, Other Links
	Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [Primary Screening] Source: The Scripps Research Institute Molecular Screening Center Protein Target: glutathione-S-transferase omega 1 [Homo sapiens] [gi: 4758484] Compounds Active: 1284; Tested: 2366 Description: Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TSRI)... more

11:	AID: 2175	Summary	Related BioAssays, Target, Literature, Other Links
	Summary of probe development efforts to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [Summary] Source: The Scripps Research Institute Molecular Screening Center Protein Target: glutathione-S-transferase omega 1 [Homo sapiens] [gi: 4758484] Substances Active: 0; Tested: 0 Description: Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TSRI)... more

12:	AID: 2174	Summary \| Data (Active)	Related BioAssays, Chemicals, Target, Literature, Other Links
	Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 1 (LYPLA1). [Primary Screening] Source: The Scripps Research Institute Molecular Screening Center Protein Target: lysophospholipase 1 [Homo sapiens] [gi: 5453722] Compounds Active: 499; Tested: 315005 Description: Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provider:... more

13:	AID: 2173
	Source: The Scripps Research Institute Molecular Screening Center Deposit Date: 2009/12/04 \| Hold-until Date: 2010/12/01

14:	AID: 2172
	Source: The Scripps Research Institute Molecular Screening Center Deposit Date: 2009/12/04 \| Hold-until Date: 2010/12/01

15:	AID: 2093	Summary	Related BioAssays, Target, Literature, Other Links
	Summary assay for inhibitors of Mint1 [Summary] Source: Burnham Center for Chemical Genomics Protein Targets: Mint1 [Rattus norvegicus] [gi: 2625023]; calcium channel, voltage-dependent, N type, alpha 1B subunit [Homo sapiens] [gi: 4502523] Substances Active: 0; Tested: 0 Description: Data Source: Burnham Center for Chemical Genomics (BCCG) Source Affiliation: Burnham Institute for Medical Research (BIMR, San Diego, CA) Network: NIH... more

16:	AID: 2073	Summary \| Data (Active)	Related BioAssays, Chemicals, Target, Literature, Other Links
	Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [Primary Screening] Source: Burnham Center for Chemical Genomics Protein Targets: Mint1 [Rattus norvegicus] [gi: 2625023]; calcium channel, voltage-dependent, N type, alpha 1B subunit [Homo sapiens] [gi: 4502523] Compounds Active: 567; Tested: 292335 Description: Data Source: Burnham Center for Chemical Genomics (BCCG) Source Affiliation: Burnham Institute for Medical Research (BIMR, San Diego, CA) Network: NIH... more

17:	AID: 2014	Summary \| Data (Active)	Related BioAssays, Chemicals, Target, Literature, Other Links
	uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) [Primary Screening] Source: Burnham Center for Chemical Genomics Protein Target: poly(A) binding protein, cytoplasmic 1 [Homo sapiens] [gi: 46367787] Compounds Active: 2954; Tested: 290927 Description: Data Source: Burnham Center for Chemical Genomics (BCCG) Source Affiliation: Burnham Institute for Medical Research (BIMR, La Jolla, CA) Network: NIH... more

18:	AID: 2012	Summary \| Data (Active)	Related BioAssays, Chemicals, Target, Literature, Other Links
	uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) [Primary Screening] Source: Burnham Center for Chemical Genomics Protein Target: Eukaryotic translation initiation factor 4H [Homo sapiens] [gi: 45219878] Compounds Active: 2728; Tested: 290927 Description: Data Source: Burnham Center for Chemical Genomics (BCCG) Source Affiliation: Burnham Institute for Medical Research (BIMR, La Jolla, CA) Network: NIH... more

19:	AID: 1918	Summary \| Data (Active)	Related BioAssays, Chemicals, Target, Literature, Other Links
	High throughput discovery of novel modulators of ROMK K+ channel activity: Primary Screen [Primary Screening] Source: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Protein Target: Potassium inwardly-rectifying channel, subfamily J, member 1 [Homo sapiens] [gi: 223460826] Compounds Active: 2463; Tested: 125269 Description: Assay Provider: Jerod Denton Assay Provider Affiliation: Vanderbilt University Grant Title: High throughput discovery of novel modulators of ROMK K+ channel... more

20:	AID: 2171	Summary \| Data (Active)	Related BioAssays, Chemicals, Target, Literature, Other Links
	Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of Protein Phosphatase Methylesterase 1 (PME-1). [Primary Screening] Source: The Scripps Research Institute Molecular Screening Center Protein Target: protein phosphatase methylesterase 1 [Homo sapiens] [gi: 7706645] Compounds Active: 1068; Tested: 1514 Description: Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provider:... more